Path: utzoo!attcan!uunet!bionet!bionet-20.bio.net!GOAD.DAVISON From: GOAD.DAVISON@BIONET-20.BIO.NET (Dan Davison) Newsgroups: bionet.general Subject: biological analysis algorithms Message-ID: <12503227250.13.GOAD.DAVISON@BIONET-20.BIO.NET> Date: 19 Jun 89 00:38:36 GMT Sender: daemon@NET.BIO.NET Lines: 42 [T]he reviewer notes that little information is provided on the Algorithms and actual methods used by computers. Could some one suggest a good book covering these areas. The Bionet mailer didn't believe the poster's addresss, so I'm posting this to Bionet-News. There are a number of excellent works that review the algorithms mentioned by Lesk. First and foremost is the CRC Press book, edited by Mike Waterman, called "Mathematical Methods for DNA Sequences". The only drawback to this book is its price, about $150.0 Gunnar von Heijne has a book whose title is something like "Biological Sequence Analysis" and whose subtitle is the memorable "Treasure Trove or Trivial Pursuit". It covers most of the methods a molecular biologist would want to use. I reviewed it recently in Mathematical Biosciences. He reviews the algorithms and their weaknesses; the book's main problem is that it does not cover the alignment algorithms well. Depending on your taste, there are some reviews to note on sequence alignment algorithms. The first is Mike Waterman's review in the Bulletin of Mathematical Biology, 1984, 46(4):473-500, "General Methods of Sequence Comparison". Next I would put Seller's "The Theory and Computation of Evolutionary Distances: Pattern Recognition" J. Algorithms 1:359-373, 1980. Lastly, there is an excellent book edited by David Sankoff and Joseph Kruskal, "Time warps, string edits, and macromolecules: The theory and practice of String Comparison" (Addison-Wesley, Reading, MA) 1983. I had a review a while back in the Bulletin of Mathematical Biology, 1985, "Sequence Similarity ('Homology') Searching for Molecular Biologists" 47(4):479 (I think). It compared implementations of search algorithms and was intended to complement the Waterman review. dan davison/theoretical biology/ los alamos national laboratory/ t-10 ms k710/los alamos nm 87545 USA/dd@lanl.gov/davison@uhou (bitnet) -------