Xref: utzoo alt.drugs:211 sci.med:11472 sci.bio:2164
Path: utzoo!utgpu!jarvis.csri.toronto.edu!mailrus!ncar!boulder!eesnyder
From: eesnyder@boulder.Colorado.EDU (Eric E. Snyder)
Newsgroups: alt.drugs,sci.med,sci.bio
Subject: sigma "opioid" receptors
Message-ID: <10518@boulder.Colorado.EDU>
Date: 6 Aug 89 03:31:18 GMT
Sender: news@boulder.Colorado.EDU
Reply-To: eesnyder@boulder.Colorado.EDU (Eric E. Snyder)
Distribution: usa
Organization: University of Colorado, Boulder
Lines: 24

Well, alt.drugs has been pretty dead recently (or does this have something to 
do with the lightning strike at CU recently...) so here is something to think
about....:

In the latest volume of the ACS publication Annual Review of Medicial Chemistry
there was an article on antipsychotic agents mentioning sigma receptors as a 
sub-class of adrenergic or dopaminergic receptors....

At NIDA, I ran a few sigma opioid receptor binding assays for Michael Kuhar....
For the blanks, spiroperidol was used (to compete all specific binding off the 
tissue).  Think spiroperidol -> think haloperidol....

I have been out of the literature for a while.... what is the current thinking
on sigma receptors?  What is their endogenous ligand?  A opioid peptide? a   
monoamine?

-------------------------------------------------------------------------
AAGGTGCAATGATGAGGAATTTTATCGTAGTTATGAATAATCCTGCAAGAGGTGCAAAACCCAGAGTACCTCA
Eric E. Snyder
Department of Molecular,              I thought it was rain for a minute;
 Cellular and Developmental Biology   I thought the game had been called.
University of Colorado, Boulder
TTCCACGTTACTACTCCTTAAAATAGCATCAATACTTATTAGGACGTTCTCCACGTTTTGGGTCTCATGGAGT
-------------------------------------------------------------------------