Path: utzoo!attcan!uunet!mailrus!iuvax!bionet!haploid!jeh From: jeh@haploid (Jamie Hayden) Newsgroups: bionet.molbio.genbank.updates Subject: (none) Message-ID: <9003201950.AA16817@haploid.LANL.GOV> Date: 20 Mar 90 19:50:23 GMT Sender: daemon@genbank.BIO.NET Lines: 128 Approved: lear@genbank.bio.net LOCUS HUMPRF1A 6218 bp ds-DNA PRI 16-FEB-1990 DEFINITION Human perforin (PRF1) gene, complete cds. ACCESSION M31951 KEYWORDS perforin. SOURCE Human DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 6218) AUTHORS Lichtenheld,M.G. and Podack,E.R. TITLE Structure of the human perforin gene: A simple gene organization with interesting potential regulatory sequences JOURNAL J. Immunol. 143, 4267-4274 (1989) STANDARD simple staff_entry FEATURES from to/span description pept 3274 3812 perforin, exon 1 /hgml_locus_uid="LN0224U" /nomgen="PRF1" 4995 6123 perforin, exon 2 pre-msg 1410 > 6123 perforin mRNA and introns IVS 1507 3269 perforin intron A IVS 3813 4994 perforin intron B BASE COUNT 1385 a 1781 c 1769 g 1283 t ORIGIN 1 gaattccaaa gtcctctctt tgattttata ggtgaggaaa ctaacgctca gaaagggggt 61 tgatatctat cgccgtgagg catacggtaa gtttctggtg aagctgggat cagaacctgt 121 ttagactttg cctctctttt cccgcagata ctttgcagga cttctatgtc cctcaaaccg 181 gccttcctgt catggtcagg aaagaaactc ctcacagcct cagcatccaa gtcaggccat 241 gggtgacagc tggaaagtga tcaggaggct gcagtttcta gaagagggtg gggacactgc 301 ggagagaaga tggggccaga ttccgagaag acagcataag cccctgttcc tgtaagagca 361 gggacggaag cagggacata aacgcaaggg atgagcccca aagtgtgacc catgagacat 421 gatgtcacat gtggtctgga gcctgcccca cttcttccca tcatatacac agttatgaga 481 acaagttgtg agaaccacct cctcccttac ccagctgccc ccaccccaga agccgtgtga 541 ttttgccccc cagtgccctg tgagtcactc cacccatgga aacctcaccc caccctgacc 601 tcaagcaagg cagagtgcag aagacatgtc ctccggtgct accagaccac tctcaccagc 661 acccacgacc tcagcagggc tggagccagc gtggaggcca ctggctgtcc tcacaaagcg 721 aggagcagga gcccctgttc gaggaacatg cttggagttc ggagcctggg ctagggtggg 781 atgtaggttg agcaggaagt ggatggcaag attagagcaa catctctctt ctcccactca 841 gggaggaggg aatggccaca ggctctgaca ctcaagaagg gccaggcaca gttccaagca 901 cttcacaaca acccctaggg tctacatgac ctacaatccc aattgttcag tgaagaaact 961 gaggcacagt gaggctgaag aaccctacca gtccacactg ctggtgcata accgagctgc 1021 ccaagccccg gcggtctggc gtgtaggccc atgctctgag ccgccgcctc tgcttgcctc 1081 ttacatccca cacatgcgat gctgtgcatc agaagcaagg agatggccct gctggcctgt 1141 tcatcaacac cagggccgag tctcaaagtc ctcagcgccc cgccctcctc cgcctgtgtg 1201 ccctgagtcc ccgagcccca gcagctctac tcggcagatg agcctctggc cctgctgctc 1261 gcttcctgag ggctgtcagt ggggagccgg atgagggctg aggacagggt gggtgctcgt 1321 gggaggggag agcacaaagg acctgtgacc acagctgggg gcggggcagg aagtagaagt 1381 gatgtgagtg gtggctggtg caaggagcca cagtgggctg cctggggggc tgatgccacc 1441 attccaggag cctcggtgaa gagaggatat ccatctgtgt agccgcttct ctatacggga 1501 ttccaggtaa ggagagagca gggattgggg gcctggggcc ctgggtggag gggaagaggc 1561 tgatggagca ggaagtgctg tgacctataa gacaagacac ctgggtcaca gacggtgccc 1621 atcactaact cgctgggcag ccctgtgtcc accctgggcc tcagtttcct catgtatgaa 1681 atgaagaggt agcgtgcagt ttctaaggcc ctgcaagtgc tgacattaaa gcttctaaga 1741 aagctggaaa gaggctccct gggacagaat accatgagag tcaggatgag ggctgagttc 1801 actggattag ggttatgact gtgcccgcct cctagctggg atgagcccag ggcctttgaa 1861 gattcccctg gcctctttgc ctccctgggg cgagccacgc tgcctgaaat tccacccttc 1921 aagtcacacc tttgggcagg gcaggaggct ccagctataa tgggggctct ccatagccct 1981 cttgtctcag aacctgtggt acccaagggc aaaggccttt gaagagctca gcttggataa 2041 ggttaggctt gggtaaggtt agagaaagga ggttccagat cataaacagg cccaggcaag 2101 gccccagaaa caccttaaaa ttaggaagaa ccttccagac aatcattgtc catagtaggc 2161 aatagggggg cccctgtcac tgccgaaggc cacagagctt ggcagggagt ggcaaagagg 2221 ggaggggcag caagaaagga tctgaagagc aaccatcgag gcctctcccc acacaaaatc 2281 caagggtgtg gtcaggtctg cccctttttc ttttttttct ttctcttttt tttttttttt 2341 tttttttgag gcagagtctt actctatcac ccaggcggga gtgcagtggt acgatcttgg 2401 ctcactgcaa cctccgcctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagtag 2461 ctgggattac aggcacccgc caccatgccc agctaatttt tgtattttta gtaaagaggg 2521 ggtttcacca cgttggccag gctggtctcg aacttctgac ctccagtgat ccacctgcct 2581 ctgcctccca cagtgttcgg tttacaggtg tgagccacca cacctggcca ggtcggcaga 2641 ttttattcta gaattcgggc tgatgttatt ccataaagct cagagggaga gcgccaaagg 2701 gaaaatgaga agaataggtg caatatagga cctcatttct cttccaattc tgttaagggc 2761 tcagtgggag ggagagaggt tagagagagt gacagagaca aagaaacaga gtgagagtca 2821 gggtgggcaa agggtggctt gttctggggc caaaaatgac acttcttcag aatgaaggct 2881 tcctcaggtc cccagacccc tccctaaacc tgctacagct actctgtccc ctcttctgtg 2941 gccacagccc cctccccacc acccacagtt gtgtcctggg gacagagcca tccacctaga 3001 tccccattag gccttaggga aattctaaaa aggggctccc cttggctggg cttttcccct 3061 ctctgggccc atctgtacaa tgtgggggct gaaccaggcc tataagggac ataccagctc 3121 tgacattcat tgaataatga cttaagagat atctcagccc ctccccttcc atgtgccctg 3181 ataatctgtg gctgtggggg aagggagcag tcatcctcca tccctccacc catggcttcc 3241 cagagcccaa gtgccccctg tctctgcagc tccatggcag cccgtctgct cctcctgggc 3301 atccttctcc tgctgctgcc cctgcccgtc cctgccccgt gccacacagc cgcacgctca 3361 gagtgcaagc gcagccacaa gttcgtgcct ggtgcatggc tggccgggga gggtgtggac 3421 gtgaccagcc tccgccgctc gggctccttc ccagtggaca cacaaaggtt cctgcggccc 3481 gacggcacct gcaccctctg tgaaaatgcc ctacaggagg gcaccctcca gcgcctgcct 3541 ctggcgctca ccaactggcg ggcccagggc tctggctgcc agcgccatgt aaccagggcc 3601 aaagtcagct ccactgaagc tgtggcccgg gatgcggctc gtagcatccg caacgactgg 3661 aaggtcgggc tggacgtgac tcctaagccc accagcaatg tgcatgtgtc tgtggccggc 3721 tcacactcac aggcagccaa ctttgcagcc cagaagaccc accaggacca gtacagcttc 3781 agcactgaca cggtggagtg ccgcttctac aggtgagagc tggggctagg ggtggggggc 3841 tggaaaaggc gcgggaaact ctgggtggtc taagagccct ggaaaggcag agttctccaa 3901 tcaaacttgg aggctgcttc caccaggaag aaactgcaat cctggctctc agacttcagg 3961 tgattcagcc ctgtggcctc ctctcatcca ggaggtccca aatctgggag tgcccagtga 4021 gacatcaagt agagagaaag tgagtgagac catgcctgag agtcccagca gggtgccatt 4081 taggtctagt gagtactgaa ccctgccttt cctgggcaca gccagccttc cacagagtcc 4141 ttcctggata gggacagagg caggagacct ggccgggtca tccttcctca tcgctgtgtg 4201 accttgagca tctcacttct ctctgagctt caatcatcca ctcaaccaat actcacacct 4261 gcctgtggca gggccacact gctgagcgac agcagtcact accctagccc ctgggagtag 4321 gaagtatggg acccatattc cacgtctgag aaaggcacag tgtttgtagg ccagacccaa 4381 gtcacctggt ctgattcatc agacctgggg gccacgtttc ctccacagag aggccgagca 4441 tggcccaagc tgtcaggatc ccgggcatgt gggacccatc cagggggacg gatggatgaa 4501 ggccacatga ctagttccaa agttcgacag ataccatcag tgcaggatca ttgcttttat 4561 gttctttttt actttttctt aaaaaaaaaa tagagatggg gtctcactat gttgcccagg 4621 ctggtctcaa actcctgggc tcaagtgatc ctcccgcctc ggcctcccaa agtgctgggg 4681 ttacaggcat gaaccactgc tcccggccag gatcattgct tttataataa gaaaattaaa 4741 aggaaagaaa aaaatgttat tttgaaaagg aaaagagaaa atacctatac agagcactga 4801 ggtccctgag gggtgagagc ggaggcattc ctgccagccc cgtgccactg tgcttgtgct 4861 ctggagccgg gcccctgggt tccagtccta gttctgccca cttacatgtg accttgagca 4921 gtcctgaagg agttatttga ttgaatgggg gaaatactcc cctgggccca gctgaggtct 4981 ctctcttctc gcagtttcca tgtggtacac actcccccgc tgcaccctga cttcaagagg 5041 gccctcgggg acctgcccca ccacttcaac gcctccaccc agcccgccta cctcaggctt 5101 atctccaact acggcaccca cttcatccgg gctgtggagc tgggtggccg catatcggcc 5161 ctcactgccc tgcgcacctg cgagctggcc ctggaagggc tcacggacaa cgaggtggag 5221 gactgcctga ctgtcgaggc ccaggtcaac ataggcatcc acggcagcat ctctgccgaa 5281 gccaaggcct gtgaggagaa gaagaagaag cacaagatga cggcctcctt ccaccaaacc 5341 taccgggagc gccactcgga agtggttggc ggccatcaca cctccattaa cgacctgctg 5401 ttcgggatcc aggccgggcc cgagcagtac tcagcctggg taaactcgct gcccggcagc 5461 cctggcctgg tggactacac cctggaaccc ctgcacgtgc tgctggacag ccaggacccg 5521 cggcgggagg cactgaggag ggccctgagt cagtacctga cggacagggc tcgctggagg 5581 gactgcagcc ggccgtgccc accagggcgg cagaagagcc cccgagaccc atgccagtgt 5641 gtgtgccatg gctcagcggt caccacccag gactgctgcc ctcggcagag gggcctggcc 5701 cagctggagg tgaccttcat ccaagcatgg ggcctgtggg gggactggtt cactgccacg 5761 gatgcctatg tgaagctctt ctttggtggc caggagctga ggacgagcac cgtgtgggac 5821 aataacaacc ccatctggtc agtgcggctg gattttgggg atgtgctcct ggccacaggg 5881 gggcccctga ggttgcaggt ctgggatcag gactctggca gggacgatga cctccttggc 5941 acctgtgatc aggctcccaa gtctggttcc catgaggtga gatgcaacct gaatcatggc 6001 cacctaaaat tccgctatca tgccaggtgc ttgccccacc tgggaggagg cacctgcctg 6061 gactatgtcc cccaaatgct tctgggggag cctccaggaa accggagtgg ggccgtgtgg 6121 tgagaacagt gagcttggaa aggaccagta tgcttggact gaaggggttc tcacagtggg 6181 agccagggct gtcttcgtat tcccattaga ccaagctt //