Path: utzoo!attcan!uunet!samsung!brutus.cs.uiuc.edu!apple!bionet!life!mia From: mia@life (Mia McLeod) Newsgroups: bionet.molbio.genbank.updates Subject: (none) Message-ID: <9003211706.AA29053@life.LANL.GOV> Date: 21 Mar 90 17:06:44 GMT Sender: daemon@genbank.BIO.NET Lines: 115 Approved: lear@genbank.bio.net LOCUS RATINSAB 5397 bp ss-mRNA ROD 15-MAR-1990 DEFINITION Rat insulin receptor mRNA, complete cds. ACCESSION M29014 KEYWORDS insulin receptor. SOURCE Rat (strain Sprague Dawley) (7-8 week-old) liver, cDNA to mRNA. ORGANISM Rattus norvegicus Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae. REFERENCE 1 (bases 1 to 5397) AUTHORS Goldstein,B.J. and Dudley,A.L. TITLE The rat insulin receptor: Primary structure and conservation of tissue-specific alternative messenger RNA splicing JOURNAL Mol. Endocrinol. 4, 235-244 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [1] kindly submitted by B.J.Goldstein, 14-OCT-1989. FEATURES from to/span description pept 348 4499 insulin receptor precursor sigp 348 425 insulin receptor signal peptide matp 426 2627 insulin receptor alpha subunit matp 2640 4496 insulin receptor beta subunit site 2628 2639 subunit cleavage site BASE COUNT 1272 a 1430 c 1402 g 1293 t ORIGIN 1 cccacccaga gctgcgggag gaggagaaac gggagacccg gccagggaac agcaaccttg 61 gtgagctctg gactctgcga ttgcggacac aggacgggcc tgggtgaccc ggggttgata 121 gtctgcgggc cggcacagtg ttgcttgcag ccgaggcctg tgtgctcttc ccaggactgt 181 ccccagggcc ctctaggctg gagatctgcg gcccgtaagc accggcgtgg aagagaagga 241 cgtgcggccc ctagcgcctg cctctccagc gaccttctcg cggagtatgt ccccagtggg 301 ccggcgtggc gtgctctgat cgccggggtc ccagcgctcc tactgctatg ggctccggga 361 gaggatgtga gacgacggcg gtgccgttgc tgatggccgt ggccgttgct ggtggcacag 421 ccggccacct gtaccctgga gaggtgtgcc cgggaatgga catccggaac aacctgacca 481 ggttgcatga gctggagaac tgctcggtca ttgagggcca tctgcagatc ctcttgatgt 541 tcaagaccag acccgaagat ttccgagacc tcagtttccc caaactcatc atgatcacag 601 actacctgct tcttttccgt gtctatggcc tagaaagtct aaaagacctc ttcccaaacc 661 tcacagtcat ccgaggctcc cgtctcttct tcaactatgc cctggtcatc ttcgagatgg 721 tccacctgaa ggagctgggt ctttacaacc tcatgaacat cacccggggc tctgtccgca 781 tcgagaagaa taatgaactc tgctacctgg ccactatcga ctggtcccgc atcctggatt 841 acgtggagga caactacatt gtactgaaca aagatgacaa tgaggaatgt ggggacgtct 901 gtccaggcac agccaagggc aagaccaact gccctgccac cgtcatcaat gggcagtttg 961 tggaacggtg ctggacacac agtcattgtc agaaagtttg cccaaccatc tgtaagtcac 1021 atggctgcac agctgaaggc ctgtgctgtc acaaggagtg cctgggcaac tgttcagaac 1081 ccgatgaccc taccaagtgt gtggcctgtc gaaacttcta cctggatggt cagtgtgtgg 1141 agacctgccc accaccctac tatcacttcc aggactggcg ctgtgtaaac ttcagcttct 1201 gccaagacct tcactacaaa tgcaggaact ctcggaagcc tggctgtcac caatacgtca 1261 ttcacaacaa caagtgcatc cccgagtgcc cgtctggcta taccatgaat tccagcaact 1321 tgatgtgcac cccgtgtctg ggaccctgtc ctaaggtctg ccaaatcctc gaaggcgaga 1381 agaccattga ttccgtgaca tctgcccagg agctccgagg ctgcactgtg atcaatggca 1441 gcctgattat caacatccga gggggcaaca acctggcagc tgaactagag gctaaccttg 1501 gcctcattga agaaatctca gggttcctaa agatccgtcg ctcctatgct ctggtgtcac 1561 tttctttctt caggaagcta catctgattc gaggagagac cttggaaatt gggaactatt 1621 ctttctacgc cttggacaac cagaacctga ggcagctgtg ggactggaac aagcacaacc 1681 tcacgatcac tcagggcaag ctcttcttcc actacaaccc caaactctgc ctgtctgaga 1741 tccacaagat ggaggaagtg tccggaacca agggccgcca ggagaggaac gacattgccc 1801 tgaagaccaa cggggaccag gcatcctgtg aaaatgaatt acttaaattc tctttcatcc 1861 ggacgtcttt tgacaagatc ttgctgaggt gggagcccta ctggcccccc gacttccgag 1921 atctcctggg attcatgctg ttctacaaag aggcccctta tcagaacgtg acagagtttg 1981 acgggcagga tgcgtgtggc tccaacagct ggactgtggt ggatattgac ccgccccaga 2041 ggtccaacga ccctaagtct cagaccccaa gccaccctgg gtggctgatg cggggcctca 2101 aaccctggac ccagtatgcc atctttgtca agaccttggt taccttctct gatgaacgcc 2161 ggacctatgg agccaaaagt gatatcatct atgtgcaaac agatgccacc aatccttccg 2221 ttcccctgga tcccatatca gtttccaact cctcatctca gattatctta aagtggaagc 2281 ccccctcgga ccccaatggc aacatcacac actacctggt ctactgggag aggcaggcgg 2341 aggacagtga gctgttcgag ttggattatt gtctcaaagg gctgaagctc ccctcacgca 2401 cctggtcccc accttttgag tctgacgatt ctcaaaagca caatcagagt gagtatgacg 2461 actcggccag cgagtgctgc tcatgtccta agactgactc tcagatcctg aaggagctgg 2521 aggagtcttc attcaggaag accttcgagg attacctgca caacgtggtt tttgttccca 2581 gaaaaacctc ttcaggcaat ggtgctgagg acactaggcc atcccgaaag cgaagatccc 2641 ttgaagaggt gggcaatgtg acagccacta cacccacact tccagatttt cccaacatct 2701 cctccaccat cgcgcccaca agccacgaag agcacagacc atttgagaaa gtagtaaaca 2761 aggagtcact tgtcatctct ggcctgagac acttcactgg gtaccgcatt gagctgcagg 2821 catgcaatca ggactcccca gaagagaggt caggcgtggc tgcctacgtc agtgcccgga 2881 ccatgcctga agctaaggca gatgacatcg ttggccctgt gacccatgaa atctttgaga 2941 acaatgttgt acacttaatg tggcaagagc caaaggaacc taatggtctg attgtgctat 3001 atgaagtgag ctatcggcga tatggtgatg aggagctgca cctctgtgtc tcccggaagc 3061 attttgccct ggagcggggc tgcaggcttc gagggctctc tccaggaaac tacagtgttc 3121 gagtccgggc tacctctctg gcaggaaatg gctcctggac agaacccacc tatttttatg 3181 tgactgatta tttagatgtc ccatcaaata ttgccaaaat tatcatcggg cccctcatct 3241 tcgtcttcct cttcagtgtc gtgatcggaa gtatttatct attcttgagg aagaggcagc 3301 cagatgggcc aatgggacca ctgtacgctt cttcaaaccc agagtacctc agtgccagtg 3361 atgtctttcc atcttccgta tacgttccgg atgagtggga ggtacctcga gagaagatca 3421 ccctcctccg agagctgggg cagggatcct tcggtatggt gtacgaaggc aatgccaagg 3481 atatcatcaa gggtgaggta gagacccgtg ttgcggtgaa gacggtcaat gagtcagcca 3541 gtcttcgaga acggatcgag ttcctcaatg aggcatcagt catgaagggc ttcacctgtc 3601 atcacgtggt ccgccttctt ggggtggtgt ccaaaggcca gcccacattg gtagtgatgg 3661 aactgatggc tcatggagac ctgaaaagtc acctccgttc tctgcggccc gatgctgaga 3721 acaacccagg ccgtcctccc cctaccttgc aagaaatgat tcagatgaca gcagaaattg 3781 ccgatggcat ggcatacttg aacgccaaga agtttgtgca ccgggacctg gcagctcgga 3841 actgcatggt tgcccatgat tttactgtca aaatcggaga ctttggaatg acgagagaca 3901 tctacgagac agattactat cggaaagggg gcaaggggtt gctgcccgtg aggtggatgt 3961 cacccgagtc cctgaaggac ggagtcttca ctgcttcttc cgacatgtgg tcctttgggg 4021 tggtcctttg ggaaatcacc agcctggctg agcaacctta ccaaggcctg tctaatgaac 4081 aggtgttgaa atttgtcatg gatggaggct atctggatcc ccctgataac tgtccagaga 4141 gactcactga cctgatgcgc atgtgctggc agttcaaccc caagatgagg ccgaccttcc 4201 tggaaatcgt caacctgctc aaggacgacc tccaccccag ctttccggaa gtttccttct 4261 tctacagcga ggagaacaag gctcccgaga gtgaagagct ggagatggag ttcgaggaca 4321 tggagaatgt ccccttggat cgttcctctc actgtcagag agaagaggct ggatgccgcg 4381 agggagggtc ctctctgagc atcaaacgga cctatgatga acacatcccc tacacccaca 4441 tgaacggggg caagaagaat gggcgggtcc tcaccctgcc gaggtcgaac ccttcctaac 4501 agcgcctgct cgctcgggga aggattcttt tcttttcttt ctttcttttt aaaaactctt 4561 ctgtagtttg actgcctcca ggaaactcag gattatcggg actctaccca gatgtgaaac 4621 tgagctcaca gatagttcgt acacatttct gtttgtcttt ggacctgaaa acacacaggt 4681 gtggtcgcca accctgcgag cctgtggagg gctaactgtg aacctagagg ggttggggtt 4741 tccatactcc cttccctgcc cccacggtat caaaccaaga ttttattgtt tgttgctggt 4801 gttttcctca tagattggaa ggatgaacct gtttttacag tttttttttt tctgctagtg 4861 tctgagttat agttagttgt caaagacaga ctttatttat ggagcacaag tcagaaagca 4921 aagaagaaac agacagaaaa acaaaacaaa aaccaaacct gacctacaga acccagttct 4981 ggaattgcgt gctttcgcgg ggttgggctt tgagaaggtt tcattaatct gagagaagga 5041 gcttatttta ttttagtttt gttttatttt tttcctcatt cacaaaatca gttcctcaaa 5101 ttgaccaata gctgctgctt tcatatttta ttattttggg aaagggtgtg tactcctaag 5161 tgtgtgctca tctgcacact gcgtgcattt gcgtgtgtgt tgtgtccagg gtagcggtca 5221 cagggtgggg tgggggctgt ctgtatgtta catttttctc tggattgatg cttggtgact 5281 tggctcatga agcacccgct gcttggagtg ggtgacctca tattgtcctc ttccttctta 5341 tgaaccgaga gcttgtgccc tcgagagatt ctcctcagtc acgtcagaac tcgctcg //