Path: utzoo!attcan!uunet!bionet!life!mia From: mia@life (Mia McLeod) Newsgroups: bionet.molbio.genbank.updates Subject: (none) Message-ID: <9003162125.AA27184@life.LANL.GOV> Date: 16 Mar 90 21:25:08 GMT Sender: daemon@genbank.BIO.NET Lines: 240 LOCUS GIBHBGGL 11493 bp ds-DNA PRI 13-DEC-1989 DEFINITION Gibbon gamma-1 and gamma-2 globin genes, complete cds. ACCESSION J05174 KEYWORDS Alu repetitive sequence; fetal globin; gamma-1-globin; gamma-2-globin; gamma-globin; hemoglobin. SOURCE Gibbon adult blood DNA, clones HlaCh40-[14.5,12.5], pHla14.5-R[8.0,0.6,2.3,1.8] and pHla12.5-K6.5. ORGANISM Hylobates lar Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hylobatidae. REFERENCE 1 (bases 1 to 1897; 3922 to 6318; 8847 to 11493) AUTHORS Fitch,D.H.A., Tagle,D., Sieu,L., Bailey,W., Goodman,M. and Slightom,J.L. TITLE Molecular reconstruction of a gene duplication: Nucleotide sequences surrounding the gamma-globin genes of gibbon, rhesus, spider monkey and galago JOURNAL Unpublished (1989) Wayne State Uni. School of Medicine. STANDARD full staff_review REFERENCE 2 (bases 1898 to 3921; 6319 to 8846) AUTHORS Fitch,D.H.A., Mainone,C., Goodman,M. and Slightom,J.L. TITLE Molecular history of gene conversions in the primate fetal gamma- globin genes: Nucleotide sequences from the common gibbon, Hylobates lar JOURNAL J. Biol. Chem. 265, 781-793 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [1] and [2] kindly submitted by D.H.A.Fitch, 20-NOV-1989. FEATURES from to/span description pept 2216 2307 gamma-1-globin, exon 1 2431 2653 gamma-1-globin, exon 2 3536 3664 gamma-1-globin, exon 3 pept 7136 7227 gamma-2-globin, exon 1 7351 7573 gamma-2-globin, exon 2 8468 8596 gamma-2-globin, exon 3 IVS 2308 2430 gamma-1-globulin intron A IVS 2654 3535 gamma-1-globulin intron B IVS 7228 7350 gamma-2-globulin intron A IVS 7574 8467 gamma-2-globulin intron B rpt 54 362 Alu repeat signal 2075 2079 gamma-1-globin CAAT box signal 2132 2137 gamma-1-globin AATAAA box signal 3725 3730 gamma-1-globin poly-A signal signal 6995 6999 gamma-2-globin CAAT box signal 7052 7057 gamma-2-globin AATAAA box signal 8657 8662 gamma-2-globin poly-A signal BASE COUNT 3384 a 2251 c 2515 g 3343 t ORIGIN 1 bp upstream of BamHI site. 1 ggatcctaga tattccttag tctcaggagg agcaattaag attcacttgt ttagagactg 61 ggagcagtgg ctcacgcctg taatcccaga actttgggag gccaaggcag gcaatcacct 121 gagatcaaga gttcaagacc aacctggcca acatggtgaa atcccatctc tacaaaaata 181 tgaaaattag ccaggcatga tggtaagtgc ctgtaatccc agctactcag gaggctgagg 241 caggagaatt gcttgaaccc agaaggcggg agttgcagtg agccgagatc acaccactgc 301 actccagcct gggtgacaga acgagacacc atctcaaaaa aaaaaaaaaa aaaaagagat 361 tcaaaagatt cacgtgttta ggccttagcg ggcttagaca ccagtctctg agacattctt 421 aaaggtcagg ctctacaact ggaacccaac cagattctca gatatggtca aagatctata 481 tacacccatc tcacagatcc tctatcttaa agagacccta atttgggttc acctcggtct 541 ctgtaatctg tacctgcata ccaataaaaa tcctcaccca ctctcagatt gagagaagtc 601 acctattatt atgtgagtaa ccggaagata ctgatatgtt gacagatctt tttctttccc 661 ttcttattca acttttattt taacttccaa agaacaagtg caatatgtgc agctttgctg 721 cgcaggtcaa catgtatctt tctggtcttt tagccgtctc acactttgag cagatataag 781 ctttacacaa gattatgaag gctgaaagga ttccaccaat attattataa tttctatcaa 841 cctgataggt taggggaagg tagagctccc ctccaataag ccagatttcc agagtttctg 901 acatcataat ctaccaaagt caaggatcac tttcagagaa aaaacaaaag caaaaccaaa 961 cccaccaaac ataaaaatcc aaaagaaaaa ataaagaaaa aaacagcatg aaaacttcct 1021 gccacgttaa gtgcccaata tgttcagaaa ctgcactgag ttacagataa agatgtctaa 1081 actacagtga catctgagct gtcacaatgt gtggactatt agtcaataaa atagtccctg 1141 cctctttaga gttgttttcc acgcaaatac atgtcttatg tcttagaata agattccatg 1201 agaagtgagc ttagcattta tacaagataa ttaattctaa tccacagttc ctgccaaaga 1261 atattctacc atcatcttta ctgagcatgg aagagctaca ccaaaaccct gggtcatcag 1321 ccagcacaca cacttatcca gtgataaata cacatcatct ggtgtataca tacatacctg 1381 aatataaaaa aaaaatactt ttgctgagat gaaacaggca tgatttattt caaataggta 1441 cagataagta gatattgaag taaggattca gtcttatatt acataacatt aatctattcc 1501 tgcactgaaa ctgttgcttt ataggatttt ttttcactac actaatgaga acttaagaga 1561 taacggccta aaaccacaga gaatatattc aaagataagt atagcacttc ttatttggaa 1621 accaatgctt actaaatgag actaagactt gtcccaaaaa tcctagactt tgccaaaaat 1681 cctagacttt gccaaaaatc ctagacctat gcctaaaaca catttcacaa tccctgaact 1741 tttcaaaaac tggtacgtgc tttagcttta aactccaggc ctcactggag ctagagacaa 1801 gaaggtaaaa aaaggctgac aaaagaagtc ctggtatcct ctatggtggg agaagaaaac 1861 tagctaaagg gaagaataaa ttagagaaaa attggaatga ctgaattgga acaaggcaaa 1921 gcctataaaa aaaattaagc agcagtatcc tcttgggggc cccttcccca cactatctca 1981 atgcaaatat ctgtctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagcctt 2041 gccttgacca atagccttga caaggcaaac ttgaccaata gtcttagagt atccagtgag 2101 gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcagcctc cagcagttcc 2161 acacactcgc ttctggaacg tctgagatta ccaataagct cctagtccag acgccatggg 2221 tcatttcaca gaggaggaca aggctactat cacaagcctg tggggcaagg tgaatgtgga 2281 agatgctgga ggagaaaccc tgggaaggta ggctctggtg accaggacaa gggagggaag 2341 gaaggaccct gtgcctggca aaagtccagg tcgcttctca ggacttgtgg caccttctga 2401 ctgtcaaact gctcttgttc aatctcacag gctcctggtt gtctacccat ggacccagag 2461 gttctttgac agctttggca acctgtcctc tgcctctgcc atcatgggca acccaaaagt 2521 caaggcacat ggcaagaagg tgctgacttc cctgggaggt gccataaaga atctggatga 2581 tctcaagggc acctttgccc agctgagtga gctgcactgt gacaagctgc atgtggatcc 2641 tgagaacttc agggtgagta caggagatgt ttcagccctg ttgcctttag tcttgaggca 2701 acttagacaa ctaagtattg atctgagcac agctgaatct acccgcaggg tgtgagctat 2761 ttgaagatac tggggttggg agtgaagaaa ctgcagaaga ctaactgggc tgagacccag 2821 tggtaatgtt ttagggccta aggagtgcct ctaaaaatct agacggacaa ttttgacttg 2881 gagaaaggag atgtggaaat gaggcaaatg acttttcttt attagattcc ggtagaaaga 2941 attctaatct tttcaccatt tttgttattc gttttaaaac atctatctgg aggcaggaca 3001 agtatggtca ttaaaaagat gcaggcagaa ggcacatatt ggctcagtca aagtggagaa 3061 ctttggtggc caaacatata ttgctaaggc tattcctata tcagctggac acatacaaaa 3121 tgctgctaat gcttcattac aaacgtatgt cttctaattc cagatggggg caaagtatgt 3181 ccgggggtga ggaacaattg aaacatttgg gctggagtag attttgaaag tcagctgtga 3241 gtttgtgtgt gtgtgtgtgt gtgtgtgtga gcgtgtgttt cttttaacgt cttcagccta 3301 caacatacag ggttcatggt ggcaagaaga tagcaagatt taaattatgg ccagtgacta 3361 gtgctgcaag gggaacaact acctgcgttt aatgggaagg cagaatctca ggctttgagg 3421 gaagttaaca taggcttgat tctgggtgga agctgggtgt gtagttatct ggaggccagg 3481 ctggagtctc agctcactat gggttcatct ttgttgtctc tttccatctc aacagctcct 3541 gggaaatgtg ctggtgaccg ttttggcaat ccatttcggc aaagaattca cccctgaggt 3601 gcaggcttcc tggcagaaga tggtggccgg agtggccagt gccctgtcct ccagatacca 3661 ctgagccccc tgcccatgat gcagagcttt caaggatagg ctttattctg caagcaataa 3721 aaataataaa tctattctgc taagagatca cacacggttg tcttcagttc tttttttatg 3781 tctttttaaa tatatgagcc acaaagggtt ttatgttgag ggatgtgtgt atgtgtattt 3841 gtacatggct gtgtgtgttt gtgtcatgtg cgtactcctc acttttttgt ttacatgaga 3901 tgtgggtttt gatgagcaaa taaaagaact aggcaataaa gaaacttgta catgggagtt 3961 ctgcaagtgg gagtaaaagg tgtaggagaa atctggtggg aagaaaggcc tctataggac 4021 aggactcctc agaaacacat ggtttggaag agatggggaa aggttcagtg aaagtgctga 4081 acccccttca ctggattgca gcacagcagt gaggaagggg ctcaacaaag aaaaagtgtt 4141 ccaagcttta ggaagtcaag gtttaggcag ggatagccat tctattttat taggagcaat 4201 actatttcta atggcatctg gcttttctca gcccttgtga ggctctatgg ggaggttgag 4261 gtgttaggga tcagagcagg aaacaggttt ttctttccac ggtaactaca atgaagtgat 4321 ccttacttta ctaaggaact tttcgtttta agtgttgatg catgcctaaa gaggtgaaat 4381 taatcccgta cccttaaatg tacagactgg tcacagcact tcaaggaaga gacctcattg 4441 taagcttcta ggggaggtgg ggaattaggt gaaggaaatg agccagcaga ggctcacaag 4501 tcagcatcag cacgtcatgt ctgagcagca gaccagcatg gtcagatgaa aatgtagtgt 4561 gaagaatttg tataacatta attgagaagg cagattcact ggagttctta tataattgaa 4621 agttaatgca tgtttataag caagagttta gtttaatgtg atggtgttat gaacctaacg 4681 cttgcgtcta cagaaaattc acatgctgaa tcgccaactc ccaattggcc ccatttgtgg 4741 gggtggcttt ggaaaagtaa ttaggtttag atgagctcat gagagcagat ccccatcaca 4801 gaattatttt cctcatcaga agcagagaga ttagccattt ctcttccttc cggtgaggac 4861 agagtgggaa gtcagccacc tgcaacccag gaagagagcc ctgaccagga accagcagaa 4921 atgtgagaaa aaattctgtt gttgaagtca tccagtctat gctattttgt tatagcacct 4981 tgcactaagt aaggcagatg aagaaagaga aaaaagtgag cttgggtgtt cagtggatta 5041 gaaaccatgt ttatctcagg tatacaaatc gccactggtc ccctgtgttt cagtataaaa 5101 taccaactct actactctca tctgtaagac ccaaatagta accctgagcc cttctctcta 5161 actttgattt ctattttttc ttcaacatac tttaggcttg taatgtattt atatacagtg 5221 aaatgtcaag ttctttcttt atatttcttt ctttcttttt tctcctcagc ctcagagttt 5281 tccacatgcc cttcctactt tcaggaactt ctttctccaa acgtcttctg cctggctcca 5341 ttcatatcaa aaaggatcca cttgaaatgc agtcactcac taccatttca caatttgcac 5401 tttctttttt cttttatttt tagtaaaaca agtttataaa aaattaaacg aataaatgaa 5461 tggctacttc ataggcagag tagccctaag ggctgctggt tgccgatttt tattgtaatt 5521 tttcaatact atgctaaaca aggggtagat tatttacgct gcctattttt agaccataaa 5581 agataacttc ctgatgttgc catggcattt ttttcctttt aatttttttc atttcatttt 5641 aatttccaag gtacatgtgc aggatatgca ggcttgttac atgggtaaat gtgtatcctt 5701 ctggcctttt agccatcttt gtcaatgagc agatataagc tttacacagg atcatgaagg 5761 ctgaaaggat ttcaccaata ttattataat ttcaatcaac ctgatagctt aggggataaa 5821 ctaatttgaa gatacagctc gcctccaata gtcagaattc cagagcttct ggcattataa 5881 tctagcaagg tttgagatca tggatcactt tcagagaaaa acaaaaacaa actaaccaaa 5941 agcaaaacag aaccaaaaaa ccagcataaa tacttcctac tctgttaatg gtccaatatg 6001 tcagaaacag cactgcgtta gaaaaaaagc tgtctaaggc acactgagat tcgagttatc 6061 acagtgtgtg gactattagt caataaaaac agcccttgcc tctttagagt tgttttccat 6121 gcacatgcat gtcttatgtc ttagaataag attccctgag aagtgaacct agcatttata 6181 caagataatt aattctaatc cacagtacct gccaaagaac attctaccat catctttact 6241 gagcatagaa gagccacacc aaaaccctgg gtcatcagcc agcacacaca cttatccagt 6301 gataaataca catcatctag tgtatacata catacatgaa tatggaatca aatatttctt 6361 ctaagatgaa acagtcatga tttatttcaa ataggtacgg ataagtagat attgaggtag 6421 gcattaggtg ttatattacg taacactaat ctattactgt gctgaaactg tggctctata 6481 ggaattgttt tcactgcact attgagaact taacagataa tggcaaaagt cacagagagt 6541 atattcaaaa ggaagtatag cactttttcc ttagaaacca atgctcacta aatgagacta 6601 agatttgtcc catcaaaaat cctggaccta tgcctaaaac acatttcaca atccctgaac 6661 ttttcaaaaa ttggtacatg ctttagcttt aatctccagg cctcactgga gctagagaca 6721 agaaggtaaa aaaaggctga caaaagaagt cctggtatcc tctatgatgg gagaagaaaa 6781 ctagctaaag ggaagaataa attagagaaa aattggaatg actgaattgg aacaaggcaa 6841 aggctataaa aaaattaagc agcagtatct tcttgggggc cccttcccca cactatctca 6901 atgcgaatat ctctctgaaa cggtccctgg ctaaactcca cccatgggtt ggccagcctt 6961 gccttgacca atagccttga caaggcaaac ttgaccaata gtcttagagt atccagtgag 7021 gccaggggcc ggcggctggc tagggatgaa gaataaaagg aagcaccctc cagcagttcc 7081 acacactcgc ttctggaacg tctgagatta tcaataagct cctagtccag acgccatggg 7141 tcatttcaca gaggaggaca aggctactat cacaagcctg tggggcaagg tgaatgtgga 7201 agatgttgga ggagaaaccc tgggaaggta ggctctggtg accaggacaa gggaggggag 7261 gaaggaccct gtgcctggca aaagtccagg tcgcttctca ggatttgtgg caccttctga 7321 ctgtcaaact gctcttgttc aatctcacag gctcctggtt gtctacccat ggacccagag 7381 gttctttgac agctttggca acctctcctc tgcctctgcc atcatgggca accccaaagt 7441 caaggcacat ggcaagaagg tgctgacttc cctgggaggt gccataaaga acctggatga 7501 tctcaagggc acctttgccc agctgagtga gctgcactgt gacaagctgc atgtggatcc 7561 tgagaacttc agggtgagta caggagatgt ttcagccctg ttgcctttag tctcgaggca 7621 acttagacaa ctaagtgttg atctgagcac agctgaatct acccgcaggg tgtgagctgt 7681 ttgaagatat tggggttggg agtgaagaaa ctgcagaaga ctaactgggc tgagacccag 7741 tggtaacgtt ttagggccta aggagtgcct ttaaaaatct agacggacaa ttttgacttt 7801 gagaaaggag atgtggaaat gaggcaaatt acttttcttt attagattcc agtagaaaga 7861 gttctaatca tttcaccatt tttgttattc gttttaaaac atctatctgg aggcaggaca 7921 agtatggtca ttaaaaagat gcaggcagaa ggcacatatt ggctcagtca aaatggggaa 7981 ctttggtggc caaacatata ttgctaaggc tattcctata tcagctggac acatataaaa 8041 tgctgctaat gcttcattat aaacatatgt cttctaattc cagatggggg caaagtatgt 8101 ctgggggtga ggaacggttg aaacatttgg gctggagtag attttgaaag tcagctgtga 8161 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gagcgtgtgt ttcttttaac 8221 gtcttcagcc tacaacatac agggttcatg gtggcaagaa gatagcaaga tttaaattat 8281 ggccagtgac tagtgctgca aggggaacaa ctacctgcat ttaatgggaa ggcagaatct 8341 caggctttga gggaagttaa cagaggcttg attctgggtg gaagctgggt gtgtagttat 8401 ctggaggcca ggctggagtc tcagctcact atgggttcat ctttgttgtc tcttttcatc 8461 tcaacagctc ctgggaaatg tgctggtgac cgttttggca atccatttcg gcaaagaatt 8521 cacccctgag gtgcaggctt cctggcagaa gatggtggct ggagtggcca gtgccctgtc 8581 ctccagatac cactgagccc cctgcccatg atgcagagct ttcaaggata ggctttattc 8641 tgcaagcaat aaaaataata aatctattct gctaagagat cacacatgat tttcttcagc 8701 tcttttttta catcttttta aatctatgag ccacaaaggg tttatattga gggatgtgtg 8761 tatgtgtatt tctgctgcct gtgtgtgttt gtggtgtgtg catgctcatt tattttcgta 8821 agagatgtga attttgatga gcaaataaaa gaacaaagca gtaaagacac ttgtacacgg 8881 gagttctgca agtgggagta aatggtgtag gagaaatccg gtgggaataa agccctctat 8941 aggacaggac tcctcagaaa cagatgtttt ggaagaggtg gggaaatgtt cagtgaagac 9001 ctgaggactg gattgcagca gagtagcaag gatggttctt aatgaacgga aagtgttcca 9061 agctttagga ggtcaagttt agtcaggttt agcaattcta ttttatcagg gggaatactc 9121 tttctaatgg cacttagctt ttcacagccc ttgtggatgc ctaagaaagt gaaattaatc 9181 ccatgccctc aagtgtgcag attggtcaca gcatttcagg ggagagacct cattgtaagc 9241 ttctggggag gtggggactt agctgtaaga aatgaatcag cagagcctca caagtcagca 9301 tgagcatgtt atgtctgagc aacaggccag cactgtgaga tcaaaatgta gtgggaagaa 9361 tttgtacaac attaattgga aggcttactc aatggaattt ttttatagtt ggatgttagt 9421 gtatctctat aaataagagt ttaatgtgat ggtgttatgg acctaatgtt tgtgtctcct 9481 caaaattcac atgctgaatc cccaactccc aactgacctt atctgtaggg gaggcttttg 9541 aaaagtaatt aggtttagat gagctcatga gagcagatcc ccatcataaa attattttcc 9601 ttatcagaag cagagagacc agccattcct ccttcctcca ggtgaggaca cagtgagaag 9661 tcagccatct gcaatccagg accacgaatc agccttcaga aatgtgagaa aaaactctgt 9721 tgttgaagcc atccagtctt tggtattttg ttatagcacc ttgcactgag taaggcagat 9781 gaagaaggag aaaaaaataa gcttgggttt tgagtggact agagaccacg tttatctcag 9841 gtttgcaaat ctcccctcgt cccctatgtt tcagtataca atacctactc tactactctc 9901 atctgtaaga cccaaataat aagcctgcgc ccttctctct aactttgatt tctcctattt 9961 ttacttcaac atgctttact ctagccttgt aatatcttta catacagtga aatgtaaagt 10021 tctttattct ctttttctct ttctttcttt ccttcttttt cttccttcct tccttccttt 10081 ctctttcttt cctttctttc ttttttctcc tcagcctcag aatttggcac atgcccttcc 10141 ttctttcaag aacttctcca aacgtctctg cctggctcca tcatatcata aaggtcccac 10201 ttcaaatgca gtcactacca tttcagaata cgtactttct ttctttcttt ttttgttttt 10261 tgtttttttt aagtcgaagc aaatttcttg agagtaaaga aataaatgaa tgactactgc 10321 ataggcagag cagctctgag ggccactggc tgttcatttt catggttatt tcttgatgat 10381 atgttaaaca agttttgcat tatttatgcc ttctcttttt aggcgataga gggtaacttc 10441 ccgacattgc catggcattt gttttttttt cttttaattt aatttaatgt taccttaaat 10501 tcaggggtac atgtacagga tatgcagatt tgttttatag gtagaagtgt gccatggttt 10561 taatggggtt ttgtgtgtgt gtgtgtgtgt gaagttgttt aagtttctta tttactctgg 10621 atattaggcc tttgtcagaa gaacagattg gaaaaatttt ttcccattct gtagattgtc 10681 tttcactctg atggtagttt cttttgctgt gcaggagctc tttagtttaa ttagattcca 10741 tttgtcaatt tttgcttttg ctgcaattgc ttttcatgtt ttcaccatga aatctgtgcc 10801 cgtgcttata tcatgaatgg tattgccttg atttttttct aggcttttta tagtttgggg 10861 tttttcattt aagtctctaa tccatctgga gttaattttt ggataaggta taaggaagga 10921 gcccagtttc atttttcagc atatggctag ccagttctcc cccatcattt attaaattga 10981 aaatcctttc cccattgctt gcttttgtca ggtttctcaa agaccagatg gtttgtagac 11041 acaatatgca gtttcttcaa gtcatataat accatctgaa atctcctatt cattcatttc 11101 ttttagtatg tatgctggtc tcctctgctc actatagtga gggcaccact aaaccagaga 11161 atctgtctgt ctagttcatg taagattctc agaattaaga aaaatggatg gtatatgaat 11221 gaaacttaat ggatgacata tggaacctaa tatgtatttg ttgaattaat tcataaaatg 11281 caacaaggga gaagttgaca actgcaatga taacctggta ttgatgatat aagagtctat 11341 agatcacagt ggaagcaata atcatggaaa acaattggaa acggggaaca gccacaaaca 11401 agaaagaatc aatacttcca ggaaagtgac tgcaggtcac ttttcctgga gcagatgaga 11461 gaaaagtgga agtcagcagt aactgctgaa ttt //