Path: utzoo!utgpu!watserv1!watmath!uunet!cs.utexas.edu!usc!apple!bionet!daemon From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Database Update Message-ID: <9004091609.AA07917@life.lanl.gov.LANL.GOV> Date: 9 Apr 90 16:09:23 GMT Sender: daemon@genbank.BIO.NET Distribution: bionet Lines: 160 Approved: lear@genbank.bio.net Checksum: 22009 11 LOCUS HUMSHBGA 6087 bp ds-DNA PRI 31-JAN-1990 DEFINITION Human human sex hormone-binding globulin (SHBG) gene, complete cds. ACCESSION M31651 KEYWORDS human sex hormone-binding globulin. SOURCE Human adult testis DNA, clone hgSH!BG-6. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 6087) AUTHORS Hammond,G.L., Underhill,D.A., Rykse,H.M. and Smith,C.L. TITLE The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs JOURNAL Mol. Endocrinol. 3, 1869-1876 (1989) STANDARD simple staff_review COMMENT A region of SHBGr-3 mRNA contains an inverted exon. However, the paper does not state the boundaries. This exon is related to a palindromic sequence "atcttggctcagtctccacctccaagat" located at positions 4455-4482. FEATURES from to/span description pept 2643 2753 sex hormone-binding globulin, exon 1 2886 2977 sex hormone-binding globulin, exon 2 3150 3339 sex hormone-binding globulin, exon 3 3670 3831 sex hormone-binding globulin, exon 4 4059 4218 sex hormone-binding globulin, exon 5 4349 4485 sex hormone-binding globulin, exon 6 5218 5425 sex hormone-binding globulin, exon 7 5670 5818 sex hormone-binding globulin, exon 8 sigp 2643 2732 sex hormone-binding globulin signal peptide matp 2733 2753 sex hormone-binding globulin 2886 2977 sex hormone-binding globulin 3150 3339 sex hormone-binding globulin 3670 3831 sex hormone-binding globulin 4059 4218 sex hormone-binding globulin 4349 4485 sex hormone-binding globulin 5218 5425 sex hormone-binding globulin 5670 5815 sex hormone-binding globulin IVS 2754 2885 SHBG intron A IVS 2978 3149 SHBG intron B IVS 3340 3669 SHBG intron C IVS 3832 4058 SHBG intron D IVS 4219 4348 SHBG intron E IVS 4486 5217 SHBG intron F IVS 5426 5669 SHBG intron G mRNA 656 751 SHBG-2 mRNA, exon 1 (5' end unsure) < 2643 2753 SHBG-2 mRNA, exon 2 2886 2977 SHBG-2 mRNA, exon 3 3150 3339 SHBG-2 mRNA, exon 4 3670 3831 SHBG-2 mRNA, exon 5 4059 4218 SHBG-2 mRNA, exon 6 4349 4485 SHBG-2 mRNA, exon 7 5670 > 5818 SHBG-2 mRNA, exon 8 mRNA 540 596 SHBG-3 mRNA, exon 1 rpt 835 1223 Alu repeat rpt 1359 2002 Alu repeat rpt 4619 4928 Alu repeat BASE COUNT 1400 a 1632 c 1640 g 1415 t ORIGIN 1 bp upstream of EcoRI site. 1 gaattcggct agctcctaag gcgtgggtac ggaagctaga ttagagcaga agggccccgc 61 tgctccccga gcaggttccc aaggcgagcc cctccccctg cccccgcctc ctacgacccc 121 gctctggccg cgccactctg acccccgggt taccggcctg cagtcttcac ccgaatcagc 181 ctcaggatat ctccacagtc tccctccttg gcctctcgga tccgcacgga agccatccgg 241 atccccgctg tctgggacca aagtcccagg gcctcgcaaa cggcaactag accccttaaa 301 gggcctacgg acttggatcc tgaagagcct gagagagcgg ggtggcggga gtcggggggg 361 acggcggggt agccgcggcc tggtaagtgg agctgggatt ccggcgccgt acgggaggag 421 agagtaggcc agcgaggcga tcctctgtcc ggcatagccc caccccctcg aattctgtcg 481 cagcaggggg cacaactgtc agccaatcag cttggagaac aggcacggcc gcgtcccccc 541 caagccccac ccccgacagc tggatcttgt gactgggctc ctgggtagag ttcaaggttg 601 gagtgaagcg gcttccttgc ggttgtgtgg gtgtcccaac ctgggtcgag ataccccgcg 661 gttcaaaggc tcccccgcag tgctttttaa attgacatat gcagtgataa cctgctttag 721 cctcaggctc actcacccgc ccagaccctg ggtaagcctt aagaccctca gctctgaaag 781 ctgtttcctg cagctcttga gtagcatgaa gtgttacctc ttgggggcat ttgcattttt 841 aaatgtttta ttttatattt atttatttat ttatttttgg agatggtgta ttgctttgtc 901 gcccaggctg gggtgtagtg gcgcgatctc tgctcactgc agcctccacc tcccgagttc 961 aagcgatcct cctgtctcag cctccggagt agctggaact acagtcgcgc accggcacgc 1021 ccggctaatt tttttttctt ttttcttctc tttttttttg ttttaacgga ttctcactct 1081 gtcactcagg ctggagtgca gtggcgcgat ctcggctcac tgcaacctct ccctcctggg 1141 ttcaagcgat tctcctgcct caccctggag atagctggga ttacaggcat gggcaaccat 1201 acctggctaa tttttgtatt tttagtagag acggggtttc actatgttgg ccaggctggt 1261 ctggaactcc tgacctcaag tgatctgccc gcctcagcct tctaaagtgc ggggattaca 1321 gatgtgaccc accaagcccg gtctgtcatt tgcattttaa aatgggtcat ggggtgggca 1381 cagtggctca cacctgtaat cccagcattt tggggaggca gaggcaggcg gatcactgag 1441 atcaggaatt tgagaccagc ctgaccaaca tggtgaaacc cgtctctact aaaatacaaa 1501 attagacagg tgtggtggcg catgccttta ctcccagcta cacgggaggc tgagacagga 1561 gaatcgcttg aacctgggag gtggaggtta cagtgagccg agatcgtgcc attgcactcc 1621 agcctgggca acaaaagcga aactccatct caaaataaat aaataaaata aaatgcgtca 1681 gggagggtcg ggccttgtgg ctaatgcctg taatccaggt actttgggag gctgaggtgg 1741 gcggatcatt tcaggtcaga ggttcgagat cagcctgggc aacgtggtga aatccccgtc 1801 tctactaaaa acacaaaaaa atttgctggg cgtggtggtg cgtgcacctg tagtcccaac 1861 tactaaggag gctgagacag gaggatcgct tgaactcgag aggcagaggc agcagtgagc 1921 cgagatcact ccactgcact ccagcctggg tgatagagca agactctgtc taaaataaaa 1981 taaaataaaa taaaataaaa ttgggtcagg gagtgggtga tttctactgc tagactgttt 2041 aggccctgta ataaatggat aagggaagat aactgagagg cggggggcag gtcccttctt 2101 aatattcact gaatcataca cacagacaat accttcttgg gagacaggcc tcagaggctg 2161 ggaaaagact gggggaggag ttcagaccag atgccaggca ctgtgcctgc attttctcaa 2221 tgaaccctct ttcacagtca ccccgtaaag tattatttcc tcattttaca gcaaggacac 2281 tgaagcacaa aggtgaagtg acttggccca aggtcactca gggacagaaa tcttggagga 2341 cctagatcag gccctagagg aggagagggg agatggaata tcctctccca gttcagaaac 2401 tttctcggca gtggaggatg atagtggagg gactctgtcc ttcaccccat tgatccccag 2461 aggggtgata gctgagtctt gtgactgggc ccctgggcag gggtcaaggg tcagtgcccc 2521 tgtttccttt accccctcct ccccgggcaa cctttaaccc tccaccgccc acacgcaagg 2581 ctgcctgcct ctacacattc tcccaagagt tgtctgagcc gccgagtgga cagtggctga 2641 ttatggagag cagaggccca ctggctacct cgcgcctgct gctgttgctg ctgttgctac 2701 tactgcgtca cacccgccag ggatgggccc tgagacctgt tctccccacc caggtgcagg 2761 agcgggacag ggcactcagc tcatgcagtc ttcccttctc tcctctggcc ctgtagcagg 2821 gcctctccct ctgtctgtct ctgacatgtc cctactcagc tttgtttgtt ttctctttct 2881 gatagagtgc ccacgaccct ccggctgtcc acctcagcaa tggcccagga caagagccta 2941 tcgctgtcat gacctttgac ctcaccaaga tcacaaagta tggggttggc ctagcccttg 3001 acccagtccc ctggttctgc cctctctcca tcagctcttc tcttttccct gtcttccttt 3061 ccttatctgt gaacaccatc tcccccaaac ccacactggt tctcaaagga cacatgacat 3121 acacaatctt tccttctgtg tccttccaga acctcctcct cctttgaggt tcgaacctgg 3181 gacccagagg gagtgatttt ttatggggat accaacccta aggatgactg gtttatgctg 3241 ggacttcgag acggcaggcc tgagatccaa ctgcacaatc actgggccca gcttacggtg 3301 ggtgctggac cacggctgga tgatgggaga tggcaccagg taagctagct ctggtcctca 3361 ggggagggat gtctggagct ggtctgagga aagggaacaa aaccaagtta ttgggcatcc 3421 ctttaccact gtcatctcgt ttaatccaca cgaaccccca caaagtagct attcttggcc 3481 ccatcttttc tgatgggaat tctaaggctc agtcagtata taagtgacaa gagctgagtg 3541 acccaaggcc aaggatgcta gctgcttctt taaggcatgt tctttccact atagtactag 3601 gctgcctcac aggaaggtgg cagaaacaga tcccaggggc ctctgatttt gcttcccacc 3661 ttcctgcagg tggaagtcaa gatggagggg gactctgtgc tgctggaggt ggatggggag 3721 gaggtgctgc gcctgagaca ggtctctggg cccctgacca gcaaacgcca tcccatcatg 3781 aggattgcgc ttggggggct gctcttcccc gcttccaacc ttcggttgcc ggtaactaca 3841 ccccaggggt ggaaccctag ccaagacttg gtaaagcact gctgggtggc tggccgtggg 3901 aatctaagtc cacactttta gggagaaggg aagggttgag agctgcaagg gggaggccaa 3961 atgctcagag gggagtcaac tgagggcagg gaggtcggga ctgcgcctcc gatgccctga 4021 tttctacatc cccgtatctt atctctgtca cactccagct ggttcctgcc ctggatggct 4081 gcctgcgccg ggattcctgg ctggacaaac aggccgagat ctcagcatct gcccccacta 4141 gcctcagaag ctgtgatgta gaatcaaatc ccgggatatt tctccctcca gggactcagg 4201 cagaattcaa tctccgaggt agatttcctc ggagtctatt tttcccaccc tggccagctc 4261 agcctgcctc tgtccccctc taccactggc ccctttcctc cttgagaccc cagctttgag 4321 gcctcaggat aatcatttct ccccacagac attccccagc ctcatgcaga gccctgggcc 4381 ttctctttgg acctgggact caagcaggca gcaggctcag gccacctcct tgctcttggg 4441 acaccagaga acccatcttg gctcagtctc cacctccaag atcaagtaag ggacagtggg 4501 cattgcctgt attcagtgga gcctggagca atgaggaaga gggagtccaa catgtcaata 4561 ttaggaaggt ttccagccca gggaacataa caagactggc tccacagaat tgtttttcat 4621 taataattag ccaggcatgg tggtggtgct tgcctgtaat cccaggtgct ggaggccaag 4681 accagaggat cacttgaggc caggagtttg acaccagcct gggcaacata gcagagacct 4741 ctgtctaaaa aaaaaaaaaa attagccagg catggtagca catgtctgct gccctagcta 4801 tttaggagcc tgaggcagga ggttcacttg agcccaggag tttgaagctg cagtgagcta 4861 tgatgtgcca ctgcactctg acctgggcca cagtgagacc ctgtctcaaa aaataaaaat 4921 aaaaataagg cttatggatg gcactcaggt gggtggtagg ggcgagggac atatcttgaa 4981 gctccccaca gcaagcaaac agttttgact tagactgcat atttacttgg ggcaggtgtg 5041 gtttcaaaaa gggtcaagcc aaaaaaaatt ggggcaggat ttaagtggtg agaatggcca 5101 gtaggtggag gcatagcgaa gaggcagaat taaggcagct aggggtgagg ccacaggcag 5161 taggcccggc tcattcttcc ctctctctct accgtccctt tcccacacac tctgcagaag 5221 gtggtgttgt cttctgggtc ggggccaggg ctggatctgc ccctggtctt gggactccct 5281 cttcagctga agctgagtat gtccagggtg gtcttgagcc aagggtcgaa gatgaaggcc 5341 cttgccctgc ctcccttagg cctgctcccc tcccttaacc tctgggccaa gcctcaaggg 5401 cgtctcttcc tgggggcttt accaggtaag agagaatgat gttcaagttc atgagcacaa 5461 cattggaaac agctcaaggg aggcggcaca ttttgagggg aaggaaacct ctgggaggga 5521 agaagaatag gccacaagaa gaagatatgg gggcagtgga aggtagtgct tttgcaaact 5581 caggttggag gagtggaaaa gtggggagaa gattctggat ccgagccacc ttaatgctct 5641 aatgccacct ttgcactacc tccctctagg agaagactct tccacctctt tttgcctgaa 5701 tggcctttgg gcacaaggtc agaggctgga tgtggaccag gccctgaaca gaagccatga 5761 gatctggact cacagctgcc cccagagccc aggcaatggc actgacgctt cccattaaag 5821 ctccacctaa gaaccccctt tgaaagttac tgattattca tttattcaac aaatattcac 5881 tgtgcactag caatgtacca ggcactgtgc caagtattga gttgtcttaa tgagcaaaaa 5941 cactctggtt cctaccctct tggtgcccac agtcccatag ggaagcagac atccatcaaa 6001 ggctaactaa taagtggata gttggaagca ctgataaaga agaattggag agttgtgaaa 6061 acatggagac tggcgggcgt gtggctc //