Path: utzoo!utgpu!news-server.csri.toronto.edu!clyde.concordia.ca!uunet!tut.cis.ohio-state.edu!zaphod.mps.ohio-state.edu!usc!jarthur!ucivax!ucla-cs!claris!netcom!jfh@ames.arc.nasa.gov From: claris!netcom!jfh@ames.arc.nasa.gov (Jack Hamilton) Newsgroups: sci.med.aids Subject: CD-4 Summary: Nomenclature trivia Message-ID: <38253@shemp.CS.UCLA.EDU> Date: 22 Aug 90 05:15:52 GMT Sender: news@CS.UCLA.EDU Organization: Netcom- The Bay Area's Public Access Unix System {408 241-9760 guest} Lines: 18 Approved: phil@wubios.wustl.edu Note: Copyright 1990 by Daniel R. Greening. Permission granted for Note: non-commercial reproduction. Archive-number: 2401 I have wondered where the name "CD4" comes from, but I've never remember to ask someone who knows. I was reading the description of a drug called "Orthoclone" last night. Orthoclone is an immunosuppressant and is used to help prevent graft rejection by blocking the function of CD3 in T cells. The description included this sentence: "The CD3 designation identifies the specificity of the antibody as the Cell Differentiation (CD) cluster 3 defined by the First International Workshop on Human Leukocyte Differentiation Antigens." So now I know. -- Because of mail/disk problems at Netcom, I have adopted the policy of responding in some way to all non-listserv/non-acknowledgement email. If you don't hear from me, I didn't get it. Jack Hamilton jfh@netcom.uucp or claris!netcom!jfh