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From: wrp@biochsn.acc.Virginia.EDU (William R. Pearson)
Newsgroups: sci.physics,sci.bio,sci.chem,sci.med
Subject: Re: Forgotten Entities: Do You Remember Any?
Message-ID: <1990Nov1.131839.6323@murdoch.acc.Virginia.EDU>
Date: 1 Nov 90 13:18:39 GMT
References: <1990Oct25.232546.12357@portia.Stanford.EDU> <35412@cup.portal.com> <18502@ultima.socs.uts.edu.au>
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In article <18502@ultima.socs.uts.edu.au> osborn@ultima.socs.uts.edu.au (Approx...) writes:
>
>Tumo(u)rs attract a blood supply when they become malignant.
>A substance named Tumo(u)r Angiogenesis Factor has been named
>as the agent which attracts arteries - it has never been
>identified. (As far as I know...).
>

	This substance has been cloned from several organisms.  Here is
a reference from the Protein Identification Resource. (It is my understanding
that "factors" that people do not believe in are cloned surprisingly
frequently.)

ENTRY           NRHUAG     #Type Protein
TITLE           Angiogenin precursor - Human
DATE            13-Aug-1986 #Sequence 13-Aug-1986 #Text 31-Dec-1989
PLACEMENT        332.0    4.0    1.0    1.0    1.0
SOURCE          Homo sapiens #Common-name man
ACCESSION       A00835
REFERENCE       (Sequence translated from the DNA sequence)
   #Authors     Kurachi K., Davie E.W., Strydom D.J., Riordan J.F.,
                  Vallee B.L.
   #Journal     Biochemistry (1985) 24:5494-5499
REFERENCE       (Sequence of residues 25-147 and disulfide bonds)
   #Authors     Strydom D.J., Fett J.W., Lobb R.R., Alderman E.M.,
                  Bethune J.L., Riordan J.F., Vallee B.L.
   #Journal     Biochemistry (1985) 24:5486-5494
COMMENT         It is not known if Met-1 or Met-3 is the initiator.
COMMENT         Angiogenin induces vascularization of normal and
                  malignant tissues.