Path: utzoo!utgpu!watserv1!watmath!uunet!bionet!FCRFV1.NCIFCRF.GOV!fornace
From: fornace@FCRFV1.NCIFCRF.GOV ("Fornace, Albert")
Newsgroups: bionet.jobs
Subject: (none)
Message-ID: <9012051429.AA11107@genbank.bio.net>
Date: 5 Dec 90 14:26:00 GMT
Sender: daemon@genbank.bio.net
Lines: 75

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Fellowship Position and Senior Fellowship Position
	at the National Institutes of Health, Bethesda, Maryland

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A fellowship position in my laboratory will be available 
in 1991.  Our studies involve the characterization of 
mammalian genes that are induced by DNA-damaging agents 
(including cancer chemotherapy agents, carcinogens, and 
radiation).  Emphasis will also be given to a subset of 
these genes that appear to play a role(s) in negative growth 
control.  Possible projects include an analysis of the 
regulation of these genes, characterization of their protein 
products, and study of the cellular role(s) of these protein 
products.  The current position is for a Ph.D or M.D. who 
has received his/her degree in the last 3 years.  The 
position is a yearly appointment which can be routinely 
extended for at least 3 years;  the minimum salary is 
$25,000 per year.

For a more senior investigator, a NRC position is available 
with a minimum salary of $29,000 and a range to >$35,000.  
Studies should focus on DNA-damage-inducible responses in 
mammalian cells.  Those with experience in the purification 
and characterization of DNA-binding proteins are encouraged 
to apply.  In addition to the areas listed above, emphasis 
will be given to research on activation of the HIV-1 promoter
by genotoxic stresses.     

Address inquiries to:

	Albert J. Fornace Jr.
	37 - 5C09
	NIH
	Bethesda, MD 20892
	USA                       

	phone:  301 402 0744              
	FAX (301) 496-5839 or 402-0752 
	email:  fornace@fcrfv1.ncifcrf.gov

Selected references:
Fornace, A.J. Jr., Alamo, I. Jr., and Hollander, M.C.:  DNA 
	damage-inducible transcripts in mammalian cells.  Proc. 
	Natl. Acad. Sci. USA 85:  8800-8804, 1988.
Fornace, A.J. Jr., Zmudka, B.Z., Hollander, M.C., and 
	Wilson, S.H.:  Induction of mammalian beta-polymerase mRNA by 
	DNA damaging agents in Chinese hamster ovary cells.  Molec. 
	Cell. Biol. 9:  851-853, 1989.
Fornace, A.J. Jr., Alamo, I. Jr., Hollander, M.C., and 
	Lamoreaux, E.:  Ubiquitin mRNA is a major stress-induced 
	transcript in mammalian cells.  Nucleic Acids Res. 17:  
	1215-1230, 1989.
Hollander, M.C. and Fornace, A.J. Jr.:  Induction of fos RNA 
	by DNA damaging agents.  Cancer Res. 49:  1687-1692, 1989.
Fornace, A.J. Jr., Nebert, D., Hollander, M.C., 
	Papathanasiou, M., Fargnoli, J., and Holbrook, N.:  
	Mammalian genes coordinately regulated by growth arrest 
	signals and DNA-damaging agents.  Molec. Cell. Biol. 9:4196-
	4203, 1989.
Leuthy, J.D., Fargnoli, J., Park, J.S., Fornace, A.J., Jr., 
	and Holbrook, N.J.:  Isolation and characterization of the 
	hamster gadd153 gene:  activation of promoter activity by 
	agents that damage DNA.  J. Biol. Chem. 265:  16521-6, 1990.
Fornace, A.J., Jr., Papathanasiou, M.A., Tarone, R.E., Wong, 
	M., Mitchell, J., and Hamer, D.H.  DNA-damage-inducible genes in 
	mammalian cells.  Prog. Clin. Biol. Res. 340A:  315-25, 1990.

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