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From: toms@fcs260c2.ncifcrf.gov (Tom Schneider)
Newsgroups: sci.bio
Subject: Alu locations
Keywords: alu sequences
Message-ID: <1965@fcs280s.ncifcrf.gov>
Date: 5 Dec 90 23:50:20 GMT
Sender: news@ncifcrf.gov
Organization: NCI Supercomputer Facility, Frederick, MD
Lines: 19

Hi everyone!

A friend of mine, Doug Halverson, has cloned several pieces of human DNA and
has found that they don't all have Alu sequences in them.  His question is, in
human genes that have been mapped or sequenced so far, have stretches of DNA as
long as 10 to 20 kb been found to be Alu free?

One way to answer this is to ask how many Alu sequences are in the genome.
According to Darnell (J. Darnell and H. Lodish and D. Baltimore", title =
"Molecular Cell Biology", year = "1986", publisher = "Scientific American
Books, Inc.", address = "N. Y."}) there are 5x10^5 per genome.  Since the
genome is around 3x10^9 bp, one would expect about 1 every 10kb, but this is
guess work.  Does anyone know more about the distribution?

  Tom Schneider
  National Cancer Institute
  Laboratory of Mathematical Biology
  Frederick, Maryland  21702-1201
  toms@ncifcrf.gov


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