Path: utzoo!utgpu!watserv1!watmath!att!news.cs.indiana.edu!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human beta-hexosaminidase beta-subunit (HEXB) gene, exons 13 and Message-ID: Date: 25 Jan 91 13:01:26 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 92 Approved: lear@genbank.bio.net Checksum: 62456 6 LOCUS HUMHEXB13 939 bp ds-DNA PRI 25-JAN-1991 DEFINITION Human beta-hexosaminidase beta-subunit (HEXB) gene, exons 13 and 14. ACCESSION M23294 J03055 KEYWORDS beta-hexosaminidase; beta-hexosaminidase beta-subunit; lysosomal enzyme. SEGMENT 13 of 13 SOURCE Human DNA, clones pCosHex1, pCos[31.4,17.1] and lambda D2.3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 939) AUTHORS Neote,K., Bapat,B., Dumbrille-Ross,A., Troxel,C., Schuster,S.M., Mahuran,D.J. and Gravel,R.A. TITLE Characterization of the human HEXB gene encoding lysosomal beta- hexosaminidase JOURNAL Genomics 3, 279-286 (1988) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Neote,K., Brown,C.A., Mahuran,D.J. and Gravel,R.A. TITLE Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase JOURNAL J. Biol. Chem. 265, 20799-20806 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Genomics 3, 279-286 (1988)] kindly submitted by K.Neote, 19-AUG-1988. FEATURES Location/Qualifiers mRNA join(M23282:610..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) mRNA join(M23282:(640.641)..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) mRNA join(M23282:(665.666)..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) mRNA join(M23282:694..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..>724) /note="beta-hexosaminidase beta-subunit mRNA" /citation=J. Biol. Chem. 265, 20799-20806 (1990) intron <1..99 /note="HEXB intron L" CDS join(M23282:685..983, M23283:113..258,M23284:56..121,M23285:59..105, M23286:69..179,M23287:94..195,M23288:91..220, M23289:77..257,M23290:19..105,M23291:107..179, M23292:79..253,M23293:94..184,100..204,574..631) /note="beta-hexosaminidase beta-subunit" exon 100..204 /note="beta-hexosaminidase beta-subunit, exon 13 /nomgen='HEXB' /map='5q13' /hgml_locus_uid='LU0141W'" intron 205..573 /note="HEXB intron M" exon 574..>724 /note="beta-hexosaminidase beta-subunit, exon 14" BASE COUNT 315 a 146 c 160 g 318 t ORIGIN About 0.3 kb after segment 12. 1 ttaagaatta aggtgcctta gctttccttc tctgtctaaa cacaaaatgc taaatataaa 61 tttaaactgc ttgcggggac tgtgtgattt aaattttagg cctcgggcaa gtgctgttgg 121 tgagagactc tggagttcca aagatgtcag agatatggat gacgcctatg acagactgac 181 aaggcaccgc tgcaggatgg tcgagtaaga aatctattaa gtccagtgtg atttttaacc 241 ttcttattca gtgttagttt cttttgctat aaatagaaat gtatgttacc taacaaatag 301 taattagaag aaaccaggaa ttattttttg taagtaataa tacctgtaaa gatatattca 361 gacttgtgga ctgttttata gatacaaaaa tgttggtgta acttagaact ccatcttgag 421 ttgctttaat tttcttccct tattttcagt aatgctgtga tttagtgatt ctaatttaag 481 tttctaagat gacatgaaca tcaatctaaa atatctttat gaatgatatc aatctaaatc 541 aatctaaaat atctttattc atgttatcta cagacgtgga atagctgcac aacctcttta 601 tgctggatat tgtaaccatg agaacatgta aaaaatggag gggaaaaagg ccacagcaat 661 ctgtactaca atcaacttta ttttgaaatc atgtaaaata agatattaga cttttttgaa 721 taaaatattt ttattgattg aacctttgac cctctatctt attacattta gaggcctggc 781 atctttcttg tgagacaagc ttaaggacac aaaagaaaca caactttgtg ataccactct 841 tctgaaggct acttatagta ataacttcat agatgaacag catgattcag gtacagtggc 901 tttaaacatc aaagcacatt tctcattata taaattaaa //