Path: utzoo!utgpu!watserv1!watmath!uunet!cs.utexas.edu!wuarchive!bcm!bionet!ukc.ac.uk!FTP From: FTP@ukc.ac.uk (UKC FTP Daemon) Newsgroups: bionet.molbio.genbank Subject: Failure of your mail. Message-ID: <9102021835.AA25964@genbank.bio.net> Date: 2 Feb 91 18:35:21 GMT Sender: daemon@genbank.bio.net Lines: 117 Your mail to uk.co.pcr.svax05 failed when the file was transferred. The mail at this host was to be sent to the follow addresses. parsons_a@uk.co.pcr.svax05 This was due to an error at uk.co.pcr.svax05. The reason given was: No valid recipients - Couldn't deliver - code = 224 UKC CAMEL FTP, Sorry we couldn't help :-< The body of your mail follows. Received: from dlgm.dl.ac.uk by kestrel.Ukc.AC.UK via Janet (UKC CAMEL FTP) id aa13880; 2 Feb 91 18:08 GMT Original-Via: UK.AC.EARN-RELAY; Sat, 2 Feb 91 18:07 GMT (V40 at UK.AC.DARESBURY.DLGM) Received: from UKACRL by UK.AC.RL.IB (Mailer R2.07) with BSMTP id 7988; Sat, 02 Feb 91 18:02:14 GMT Received: from IRLEARN.UCD.IE by UKACRL.BITNET (Mailer R2.07) with BSMTP id 9827; Sat, 02 Feb 91 18:02:13 GM Received: by IRLEARN (Mailer R2.03B) id 2227; Sat, 02 Feb 91 17:58:30 GMT Date: Sat, 2 Feb 91 17:55:13 LCL Original-Sender: BIOSCI GENBANK-BB Bulletin Board Comments: Warning -- original Sender: tag was root@UKC.AC.UK From: UKC FTP Daemon Subject: Failure of your mail. X-To: GENBANKB To: "(no name)" Sender: GENBANKB%earn.irlearn%uk.ac.earn-relay@uk.ac.dl.dlgm Your mail to uk.co.pcr.svax05 failed when the file was transferred. The mail at this host was to be sent to the follow addresses. parsons_a@uk.co.pcr.svax05 This was due to an error at uk.co.pcr.svax05. The reason given was: No valid recipients - Couldn't deliver - code = 224 UKC CAMEL FTP, Sorry we couldn't help :-< The body of your mail follows. Received: from dlgm.dl.ac.uk by kestrel.Ukc.AC.UK via Janet (UKC CAMEL FTP) id aa05651; 2 Feb 91 15:18 GMT Original-Via: UK.AC.EARN-RELAY; Sat, 2 Feb 91 15:17 GMT (V40 at UK.AC.DARESBURY.DLGM) Received: from UKACRL by UK.AC.RL.IB (Mailer R2.07) with BSMTP id 5773; Sat, 02 Feb 91 15:17:42 GMT Received: from IRLEARN.UCD.IE by UKACRL.BITNET (Mailer R2.07) with BSMTP id 8420; Sat, 02 Feb 91 15:17:41 GM Received: by IRLEARN (Mailer R2.03B) id 1521; Sat, 02 Feb 91 15:15:15 GMT Date: Sat, 2 Feb 91 15:14:02 LCL Original-Sender: BIOSCI GENBANK-BB Bulletin Board Comments: Warning -- original Sender: tag was root@UKC.AC.UK From: UKC FTP Daemon Subject: Failure of your mail. X-To: GENBANKB To: "(no name)" Sender: GENBANKB%earn.irlearn%uk.ac.earn-relay@uk.ac.dl.dlgm Your mail to uk.co.pcr.svax05 failed when the file was transferred. The mail at this host was to be sent to the follow addresses. parsons_a@uk.co.pcr.svax05 This was due to an error at uk.co.pcr.svax05. The reason given was: No valid recipients - Couldn't deliver - code = 224 UKC CAMEL FTP, Sorry we couldn't help :-< The body of your mail follows. Received: from dlgm.dl.ac.uk by kestrel.Ukc.AC.UK via Janet (UKC CAMEL FTP) id aa19740; 1 Feb 91 19:26 GMT Original-Via: UK.AC.EARN-RELAY; Fri, 1 Feb 91 19:25 GMT (V40 at UK.AC.DARESBURY.DLGM) Received: from UKACRL by UK.AC.RL.IB (Mailer R2.07) with BSMTP id 7285; Fri, 01 Feb 91 19:18:54 GMT Received: from IRLEARN.UCD.IE by UKACRL.BITNET (Mailer R2.07) with BSMTP id 8203; Fri, 01 Feb 91 19:18:53 GM Received: by IRLEARN (Mailer R2.03B) id 4133; Fri, 01 Feb 91 18:39:09 GMT Date: Fri, 1 Feb 91 18:34:51 GMT Original-Sender: BIOSCI GENBANK-BB Bulletin Board From: G_LENNON@uk.ac.icrf X-To: genbankb@irlearn.ucd.ie To: "(no name)" Sender: GENBANKB%earn.irlearn%uk.ac.earn-relay@uk.ac.dl.dlgm Don Gilbert asks .... Is there a consensus view on the proper way to enter discontinuous sequences to GenBank? An otherwise continuous length of molecule contains regions which were not sequenced, of many bases in length. Options seem to be a) enter in databank under one accession number, with feature notations indicated where regions with no data exist. Drawback: users can miss feature info and incorrectly use such data as a continuous sequence. b) enter in databank under separate accession numbers for each continuous region. Drawback: sequential nature of data is obscured by separate entries. c) enter as one accession, with unsequenced regions (whose size is known, I believe, by alignment with related sequences) indicated with "N" or other symbol. Drawback: the N symbol may not be appropriate. ************************************************************************** My vote is for option (b). After all, the "sequential nature" of the entire sequence of a chromosome (from telomere to telomere) is in practice being reduced to a set of sequence files in GenBank currently. Second, those working with immunoglobulin gene segments have settled on option (b) for representing the segments that recombine somatically to form a complete ig gene, using the features table to indicate that other sequence can be found in certain other **** Rest omitted - too long!