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From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human IgH chain (monospecific rheumatoid factor) mRNA VDJ-region.
Message-ID: <Mar.27.05.05.10.1991.20238@genbank.bio.net>
Date: 27 Mar 91 13:05:10 GMT
Sender: root@genbank.bio.net
Distribution: bionet
Lines: 44
Approved: lear@genbank.bio.net
Checksum: 06941     3

LOCUS       HUMIGHRFA     426 bp ss-mRNA            PRI       27-MAR-1991
DEFINITION  Human IgH chain (monospecific rheumatoid factor) mRNA VDJ-region.
ACCESSION   M62723
KEYWORDS    V-region; diversity exon; immunoglobulin heavy chain; joining exon;
            monspecific rheumatoid factor.
SOURCE      Human synovial tissue Epstein-Barr transformed B cell, cDNA to
            mRNA, clone RF-TS1.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
            Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 426)
  AUTHORS   Pascual,V., Randen,I., Thompson,K., Sioud,M., Forre,O., Natvig,J.
            and Capra,J.D.
  TITLE     The complete nucleotide sequences of the heavy chain variable
            regions of six monospecific rheumatoid factors derived from
            Epstein-Barr virus -transformed B cells isolated from the synovial
            tissue of patients with rheumatoid arthritis
  JOURNAL   J. Clin. Invest. 86, 1320-1328 (1990)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             1..426
                     /product="immunoglobulin heavy chain"
                     /gene="IgH"
                     /codon_start=1
                     /partial
     sig_peptide     1..57
                     /gene="IgH"
                     /codon_start=1
     mat_peptide     58..426
                     /product="immunoglobulin heavy chain"
                     /gene="IgH"
                     /codon_start=58
                     /partial
BASE COUNT       93 a    109 c    134 g     90 t
ORIGIN      Chromosome 14.
        1 atggactgga cctggaggat cctctttgtg gtggcagcag ctacaggtgt ccagtcccag
       61 gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc
      121 tgcaaggctt ctggaggcac cttcagcacc tatgctatca gctgggtgcg acaggcccct
      181 ggacaagggc ctgagtccat gggagggatc acccctatgt ttggtagagc aaactacgca
      241 cagaagttcc agggcagagt cacgattact gcggacgaat ccacgagcac agcctacatg
      301 gagctgagca gcctgagatc tgaggactcg gccgtatatt tctgtgcgag agaggaccca
      361 tacggtgact acgtcgcgaa tccttttgat atctggggcc aagggacaat ggtcaccgtc
      421 tcttca
//