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From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human IgH chain (monospecific rheumatoid factor) mRNA VDJ-region.
Message-ID: <Mar.27.05.05.16.1991.20264@genbank.bio.net>
Date: 27 Mar 91 13:05:16 GMT
Sender: root@genbank.bio.net
Distribution: bionet
Lines: 44
Approved: lear@genbank.bio.net
Checksum: 17206     3

LOCUS       HUMIGHRFF     426 bp ss-mRNA            PRI       27-MAR-1991
DEFINITION  Human IgH chain (monospecific rheumatoid factor) mRNA VDJ-region.
ACCESSION   M62731
KEYWORDS    V-region; diversity exon; immunoglobulin heavy chain; joining exon;
            monspecific rheumatoid factor.
SOURCE      Human synovial tissue Epstein-Barr transformed B cell, cDNA to
            mRNA, clone RF-KL1.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
            Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 426)
  AUTHORS   Pascual,V., Randen,I., Thompson,K., Sioud,M., Forre,O., Natvig,J.
            and Capra,J.D.
  TITLE     The complete nucleotide sequences of the heavy chain variable
            regions of six monospecific rheumatoid factors derived from
            Epstein-Barr virus -transformed B cells isolated from the synovial
            tissue of patients with rheumatoid arthritis
  JOURNAL   J. Clin. Invest. 86, 1320-1328 (1990)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     CDS             1..426
                     /product="immunoglobulin heavy chain"
                     /gene="IgH"
                     /codon_start=1
                     /partial
     sig_peptide     1..60
                     /gene="IgH"
                     /codon_start=1
     mat_peptide     61..426
                     /product="immunoglobulin heavy chain"
                     /gene="IgH"
                     /codon_start=61
                     /partial
BASE COUNT       91 a    100 c    130 g    105 t
ORIGIN      Chromosome 14.
        1 atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgg tgtccagtgt
       61 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc
      121 tcctgtgcag cctctggatt cacctttagt tcatatgcca tgagttgggt ccgccaggct
      181 ccagggaagg ggctggagtg ggtctcagca attagtgata acggtggaat aacatactac
      241 acagactacg tgaagggccg gttcaccatc tccagagaca attccaagaa ccccctgtat
      301 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaaaattg
      361 aggtccgggc tcgtcccgta ctactttgac ttctggggca ggggaaccct ggtcaccgtc
      421 tcctca
//