Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!samsung!olivea!apple!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Mouse Ig rearranged H-chain mRNA constant region. Message-ID: Date: 13 Apr 91 12:01:47 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 51 Approved: lear@genbank.bio.net Checksum: 43993 3 LOCUS MUSIGHCKB 1070 bp ds-DNA ROD 13-APR-1991 DEFINITION Mouse Ig rearranged H-chain mRNA constant region. ACCESSION M60429 KEYWORDS constant region; gamma immunoglobulin; hinge exon; immunoglobulin heavy chain; processed gene. SOURCE Mouse hybridoma 24F3, cDNA to mRNA. ORGANISM Mus musculus Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae. REFERENCE 1 (bases 1 to 1070) AUTHORS French,D.L., Pollock,R.R., Aguila,H.L. and Scharff,M.D. TITLE The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding JOURNAL J. Immunol. 146, 2010-2016 (1991) STANDARD full staff_review FEATURES Location/Qualifiers CDS join(1..291,292..330,331..651,652..750) /product="Ig heavy-chain C-region" /codon_start=1 /partial exon 1..291 /note="'A/J IgG1 CH1 domain'" exon 292..330 /note="'A/J IgG1 hinge'" exon 331..651 /note="'A/J IgG1 CH2 domain'" exon 652..998 /note="'23 base addition at position 652 to 674'" /note="'A/J IgG1 CH3 domain'" 3'UTR 999..1070 BASE COUNT 269 a 328 c 252 g 221 t ORIGIN chromosome 12. 1 gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac 61 tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc 121 tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac 181 ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc 241 acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg 301 gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc 361 cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg 421 gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag 481 gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc 541 agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc 601 aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg 661 aaggcaggcc cacaggcaga ccgaaggctc cacaggtgta caccattcca cctcccaagg 721 agcagatggc caaggataaa gtcagtctga cctgcatgat aacagacttc ttccctgaag 781 acattactgt ggagtggcag tggaatgggc agccagcgga gaactacaag aacactcagc 841 ccatcatgga cacagatggc tcttacttcg tctacagcaa gctcaatgtg cagaagagca 901 actgggaggc aggaaatact ttcacctgct ctgtgttaca tgagggcctg cacaaccacc 961 atactgagaa gagcctctcc cactctcctg gtaaatgatc tcagtgtcct tggagccctc 1021 tggtcctaca ggactctgac acctacctcc acccctccct gtgtaaataa //