Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!sdd.hp.com!decwrl!apple!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Mouse Ig rearranged H-chain mRNA constant region. Message-ID: Date: 13 Apr 91 12:01:49 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 45 Approved: lear@genbank.bio.net Checksum: 11744 3 LOCUS MUSIGHCKC 726 bp ds-DNA ROD 13-APR-1991 DEFINITION Mouse Ig rearranged H-chain mRNA constant region. ACCESSION M60430 KEYWORDS constant region; gamma immunoglobulin; hinge exon; immunoglobulin heavy chain; processed gene. SOURCE Mouse hybridoma 32F3, cDNA to mRNA. ORGANISM Mus musculus Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae. REFERENCE 1 (bases 1 to 726) AUTHORS French,D.L., Pollock,R.R., Aguila,H.L. and Scharff,M.D. TITLE The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding JOURNAL J. Immunol. 146, 2010-2016 (1991) STANDARD full staff_review FEATURES Location/Qualifiers CDS join(1..291,292..330,331..654) /product="Ig heavy-chain C-region" /codon_start=1 /partial exon 1..291 /note="'A/J IgG1 CH1 domain'" exon 292..330 /note="'A/J IgG1 hinge'" mutation 330..330 /note="CH2 domain deleted" exon 331..654 /note="'A/J IgG1 CH3 domain'" 3'UTR (655.726)..(655.726) BASE COUNT 178 a 227 c 170 g 151 t ORIGIN chromosome 12. 1 gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac 61 tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc 121 tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac 181 ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc 241 acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg 301 gattgtggtt gtaagccttg catatgtaca ggcagaccga aggctccaca ggtgtacacc 361 attccacctc ccaaggagca gatggccaag gataaagtca gtctgacctg catgataaca 421 gacttcttcc ctgaagacat tactgtggag tggcagtgga atgggcagcc agcggagaac 481 tacaagaaca ctcagcccat catggacaca gatggctctt acttcgtcta cagcaagctc 541 aatgtgcaga agagcaactg ggaggcagga aatactttca cctgctctgt gttacatgag 601 ggcctgcaca accaccatac tgagaagagc ctctcccact ctcctggtaa atgatctcag 661 tgtccttgga gccctctggt cctacaggac tctgacacct acctccaccc ctccctgtgt 721 aaataa //