Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!sdd.hp.com!decwrl!apple!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Mouse Ig rearranged H-chain mRNA constant region. Message-ID: Date: 13 Apr 91 12:01:51 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 54 Approved: lear@genbank.bio.net Checksum: 00764 3 LOCUS MUSIGHCKD 1038 bp ds-DNA ROD 13-APR-1991 DEFINITION Mouse Ig rearranged H-chain mRNA constant region. ACCESSION M60432 KEYWORDS constant region; gamma immunoglobulin; hinge exon; immunoglobulin heavy chain; processed gene. SOURCE Mouse hybridoma 4F8, cDNA to mRNA. ORGANISM Mus musculus Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae. REFERENCE 1 (bases 1 to 1038) AUTHORS French,D.L., Pollock,R.R., Aguila,H.L. and Scharff,M.D. TITLE The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding JOURNAL J. Immunol. 146, 2010-2016 (1991) STANDARD full staff_review FEATURES Location/Qualifiers CDS join(1..291,292..330,331..651,652..972) /note="stop codon and following 6 bases deleted" /codon_start=1 /partial exon 1..291 /note="'A/J IgG1 CH1 domain'" exon 292..330 /note="'A/J IgG1 hinge'" exon 331..651 /note="'A/J IgG1 CH2 domain'" exon 652..972 /note="'A/J IgG1 CH3 domain'" mutation 971..972 /type="'4F8'" /note="'stop codon and following 6 bases deleted'" /note="'aa' in mutation" 3'UTR 973..1038 BASE COUNT 258 a 318 c 242 g 220 t ORIGIN chromosome 12. 1 gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac 61 tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc 121 tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac 181 ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc 241 acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg 301 gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc 361 cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg 421 gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag 481 gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc 541 agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc 601 aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg 661 aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc 721 agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg 781 aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct 841 tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc 901 acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac 961 tctcctggta tttgtccttg gagccctctg gtcctacagg actctgacac ctacctccac 1021 ccctccctgt gtaaataa //