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From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human cystic fibrosis transmembrane conductance regulator (CFTR)
Message-ID: <May.14.05.01.17.1991.10624@genbank.bio.net>
Date: 14 May 91 12:01:18 GMT
Sender: root@genbank.bio.net
Distribution: bionet
Lines: 88
Approved: lear@genbank.bio.net
Checksum: 41525     6

LOCUS       HUMCFTRA26   2106 bp ds-DNA             PRI       14-MAY-1991
DEFINITION  Human cystic fibrosis transmembrane conductance regulator (CFTR)
            gene, exon 24.
ACCESSION   M55131
KEYWORDS    cystic fibrosis transmembrane conductance regulator.
SEGMENT     26 of 26
SOURCE      Human DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
            Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (bases 1 to 2106)
  AUTHORS   Zielenski,J., Rozmahel,R., Bozon,D., Kerem,B.-S., Grzelczak,Z.,
            Riordan,J.R., Rommens,J.M. and Tsui,L.-C.
  TITLE     Genomic DNA sequence of the cystic fibrosis transmembrane
            conductance regulator (CFTR) gene
  JOURNAL   Genomics 10, 214-228 (1991)
  STANDARD  full staff_entry
FEATURES             Location/Qualifiers
     intron          order(M55130:395..>983,<1..189)
                     /number=23
                     /note="gap of unknown legnth"
                     /gene="CFTR gene"
     mRNA            join(M55106:<829..881,M55107:251..361,M55108:185..293,
                     M55109:253..468,M55110:243..332,M55111:286..449,
                     M55111:1582..1707,M55112:240..486,M55113:336..428,
                     M55114:461..643,M55115:308..499,M55116:295..389,
                     M55117:284..370,M55118:177..900,M55119:349..477,
                     M55120:220..257,M55121:363..613,M55122:326..405,
                     M55123:213..363,M55124:156..383,M55125:335..435,
                     M55126:186..434,M55127:267..422,M55128:294..383,
                     M55129:536..708,M55130:289..394,190..>2106)
                     /gene="CFTR gene"
                     /partial
     CDS             join(M55106:829..881,M55107:251..361,M55108:185..293,
                     M55109:253..468,M55110:243..332,M55111:286..449,
                     M55111:1582..1707,M55112:240..486,M55113:336..428,
                     M55114:461..643,M55115:308..499,M55116:295..389,
                     M55117:284..370,M55118:177..900,M55119:349..477,
                     M55120:220..257,M55121:363..613,M55122:326..405,
                     M55123:213..363,M55124:156..383,M55125:335..435,
                     M55126:186..434,M55127:267..422,M55128:294..383,
                     M55129:536..708,M55130:289..394,190..390)
                     /product="cystic fibrosis transmembrane conductance
                     regulator"
                     /gene="CFTR gene"
                     /codon_start=829
     exon            190..>2106
                     /number=24
                     /gene="CFTR gene"
BASE COUNT      629 a    411 c    439 g    627 t
ORIGIN      Map position 7q31-q32.
        1 agatggtaga acctccttag agcaaaagga cacagcagtt aaatgtgaca tacctgattg
       61 ttcaaaatgc aaggctctgg acattgcatt ctttgacttt tattttcctt tgagcctgtg
      121 ccagtttctg tccctgctct ggtctgacct gccttctgtc ccagatctca ctaacagcca
      181 tttccctagg tcatagaaga gaacaaagtg cggcagtacg attccatcca gaaactgctg
      241 aacgagagga gcctcttccg gcaagccatc agcccctccg acagggtgaa gctctttccc
      301 caccggaact caagcaagtg caagtctaag ccccagattg ctgctctgaa agaggagaca
      361 gaagaagagg tgcaagatac aaggctttag agagcagcat aaatgttgac atgggacatt
      421 tgctcatgga attggagctc gtgggacagt cacctcatgg aattggagct cgtggaacag
      481 ttacctctgc ctcagaaaac aaggatgaat taagtttttt tttaaaaaag aaacatttgg
      541 taaggggaat tgaggacact gatatgggtc ttgataaatg gcttcctggc aatagtcaaa
      601 ttgtgtgaaa ggtacttcaa atccttgaag atttaccact tgtgttttgc aagccagatt
      661 ttcctgaaaa cccttgccat gtgctagtaa ttggaaaggc agctctaaat gtcaatcagc
      721 ctagttgatc agcttattgt ctagtgaaac tcgttaattt gtagtgttgg agaagaactg
      781 aaatcatact tcttagggtt atgattaagt aatgataact ggaactcagc ggtttatata
      841 agcttgtatt cctttttctc tcctctcccc atgatgttta gaaacacaac tatattgttt
      901 gctaagcatt ccaactatct catttccaag caagtattag aataccacag gaaccacaag
      961 actgcacatc aaaatatgcc ccattcaaca tctagtgagc agtcaggaaa gagaacttcc
     1021 agatcctgga aatcagggtt agtattgtcc aggtctacca aaaatctcaa tatttcagat
     1081 aatcacaata catcccttac ctgggaaagg gctgttataa tctttcacag gggacaggat
     1141 ggttccctta cctgggaaag ggctgttata atctttcaca ggggacagga tggttccctt
     1201 gatgaagaag ttgatatgcc ttttcccaac tccagaaagt gacaagctca cagacctttg
     1261 aactagagtt tagctggaaa agtatgttag tgcaaattgt cacaggacag cccttctttc
     1321 cacagaagct ccaggtagag ggtgtgtaag tagataggcc atgggcactg tgggtagaca
     1381 cacatgaagt ccaagcattt agatgtatag gttgatggtg gtatgttttc aggctagatg
     1441 tatgtacttc atgctgtcta cactaagaga gaatgagaga cacactgaag aagcaccaat
     1501 catgaattag ttttatatgc ttctgtttta taattttgtg aagcaaaatt ttttctctag
     1561 gaaatattta ttttaataat gtttcaaaca tatattacaa tgctgtattt taaaagaatg
     1621 attatgaatt acatttgtat aaaataattt ttatatttga aatattgact ttttatggca
     1681 ctagtatttt tatgaaatat tatgttaaaa ctgggacagg ggagaaccta gggtgatatt
     1741 aaccaggggc catgaatcac cttttggtct ggagggaagc cttggggctg atcgaggttg
     1801 ttgcccacag ctgtatgatt cccagccaga cacagcctct tagatgcagt tctgaagaag
     1861 atggtaccac cagtctgact gtttccatca agggtacact gccttctcaa ctccaaactg
     1921 actcttaaga agactgcatt atatttatta ctgtaagaaa atatcacttg tcaataaaat
     1981 ccatacattt gtgtgaaact ttgttgtttt cagatgcgtt cacttgtcat gtttcatcag
     2041 tctctcactc caatttctaa gcttcatgga acatgaaaca cgaatctgtc ttttagatat
     2101 agcctc
//