Path: utzoo!utgpu!news-server.csri.toronto.edu!bonnie.concordia.ca!nstn.ns.ca!news.cs.indiana.edu!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Yeast (S. cerevisiae) gene HIS4 (histidine metabolism) encoding a Message-ID: Date: 17 May 91 12:08:00 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 110 Approved: lear@genbank.bio.net Checksum: 15338 8 LOCUS YSCHIS4A 4751 bp ds-DNA PLN 17-MAY-1991 DEFINITION Yeast (S. cerevisiae) gene HIS4 (histidine metabolism) encoding a polyfunctional protein which can be divided into 3 domains: HIS4 A (phosphoribosyl-AMP cyclohydrolase); HIS4 B (phosphoribosyl-ATP pyrophosphohydrolase); HIS4 C (histidinol dehydrogena ACCESSION V01310 KEYWORDS dehydrogenase; hydrolase. SOURCE Saccharomyces cerevisiae DNA. ORGANISM Saccharomyces cerevisiae Eukaryota; Plantae; Thallobionta; Eumycota; Hemiascomycetes; Endomycetales; Saccharomycetaceae. REFERENCE 1 (bases 1 to 4751) AUTHORS Donahue,T.F., Farabaugh,P.J. and Fink,G.R. TITLE The nucleotide sequence of the HIS4 region of yeast JOURNAL Gene 18, 47-59 (1982) STANDARD full automatic COMMENT SWISS-PROT; P00815; HIS2$YEAST. From EMBL 26 entry SCHIS4A; dated 06-JUL-1989. FEATURES Location/Qualifiers promoter 1230..1233 /note="possible promoter" mRNA 1269..3846 /note="messenger RNA" CDS 1332..3728 /note="HIS4 protein" /codon_start=1332 BASE COUNT 1563 a 907 c 1034 g 1247 t ORIGIN 1 ctcgagaaga acgacaatgg aaccgctatc aatacccaaa aaacagatct attgtgaggc 61 tcactaacca gttctctccc atggatgatc ctaaatcccc cacacccatg agaagtttcc 121 ggatcacgag tcggcacagc ggtaatcaac agtcgatgga ccaggaggca tcggatcacc 181 atcaacagca agaatttggt tacgataaca gagaagacag aatggaggtc gactctatcc 241 tgtcatcaga cagaaaggct aatcagaaca ccaccagcga ttggaaaccg gacaatggcc 301 acatgaatga cctcaatagc agcgaagtta caattgaatt acgagaagcc caattgacca 361 tcgaaaagct acaaaggaaa caactacact acaaaaggct actcgatgac caaagaatgg 421 ttctcgaaga agtcgaaccg acttttgata ggtatgaagc cacaatacaa gaaagagaga 481 aagagataga ccatctcaag caacaattgg agctcgaacg cagacagcaa gccaaacaaa 541 agcagttttt tgcgctgaga tgacagcttc ttgctgtcgt aagccaacta cacgaagaga 601 tcaaagaaaa cgaagagaga aatctttctc ataatcaacc cactggtgcc aacgaagatg 661 tcgaactcct gaaaaaacag ctggaacaat tacgcaacat agaagaccaa tttgagttac 721 acaagacaaa gtgggctaaa gaacgcgaac aattgaaaat gcataacgat tcgctcagta 781 aagaatacca aaatttgagc aaggaactat ttttgacaaa accacaagat tcctcatcgg 841 aagaggtggc atccttaacg aaaaaacttg aagaggctaa tgaaaaaatc aaacagttgg 901 aacaggctca agcacaaaca gccgtggaat cgttgccaat tttcgacccc cctgcaccag 961 tcgataccac ggcaggaaga caacagtggt gtgagcattg cgatacgatg ggtcataata 1021 cgcagaatgc ccccatcaca atcctgacaa ccagcagttc ttctaggcag tcgaactgac 1081 tctaatagtg actccggtaa attagttaat taattgctaa accgatgcac agtgactcac 1141 gtttttttat cagtcattcg atatagaagg taagaaaagg atatgactat gaacagtagt 1201 atactgtgta tataatagat atggaacgtt atattcacct ccgatgtgtg ttgtacatac 1261 ataaaaatat catagcacaa ctgcgctgtg taatagtaat acaatagttt acaaaatttt 1321 ttttctgaat aatggttttg ccgattctac cgttaattga tgatctggcc tcatggaata 1381 gtaagaagga atacgtttca cttgttggtc aggtactttt ggatggctcg agcctgagta 1441 atgaagagat tctccagttc tccaaagagg aagaagttcc attggtgcgt ttgtccttgc 1501 caagtggtaa attcagcgat gatgaaatca ttgccttctt gaacaacgga gtttcttctc 1561 tgttcattgc tagccaagat gctaaaacag ccgaacactt ggttgaacaa ttgaatgtac 1621 caaaggagcg tgttgttgtg gaagagaacg gtgttttctc caatcaattc atggtaaaac 1681 aaaaattctc gcaagataaa attgtgtcca taaagaaatt aagcaaggat atgttgacca 1741 aagaagtgct tggtgaagta cgtacagacc gtcctgacgg tttatatacc accctagttg 1801 tcgaccaata tgagcgttgt ctagggttgg tgtattcttc gaagaaatct atagcaaagg 1861 ccatcgattt gggtcgtggc gtttattatt ctcgttctag gaatgaaatc tggatcaagg 1921 gtgaaacttc tggcaatggc caaaagcttt tacaaatctc tactgactgt gattcggatg 1981 ccttaaagtt tatcgttgaa caagaaaacg ttggattttg ccacttggag accatgtctt 2041 gctttggtga attcaagcat ggtttggtgg ggctagaatc tttactaaaa caaaggctac 2101 aggacgctcc agaggaatct tatactagaa gactattcaa cgactctgca ttgttagatg 2161 ccaagatcaa ggaagaagct gaagaactga ctgaggcaaa gggtaagaag gagctttctt 2221 gggaggctgc cgatttgttc tactttgcac tggccaaatt agtggccaac gatgtttcat 2281 tgaaggacgt cgagaataat ctgaatatga agcatctgaa ggttacaaga cggaaaggtg 2341 atgctaagcc aaagtttgtt ggacaaccaa aggctgaaga agaaaaactg accggtccaa 2401 ttcacttgga cgtggtgaag gcttccgaca aagttggtgt gcagaaggct ttgagcagac 2461 caatccaaaa gacttctgaa attatgtatt tagtcaatcc gatcatcgaa aatgttagag 2521 acaaaggtaa ctctgttttt ttggagtaca cagaaaagtt tgatggtgta aaattatcca 2581 atcctgttct taatgctcca ttcccagaag aatactttga aggtttaacc gaggaaatga 2641 aggaagcttt gaacctttca attgaaaacg tccgcaaatt ccatgctgct caattgccaa 2701 cagagactct tgaagttgaa acccaacctg gtgtcttgtg ttccagattc cctcgtccta 2761 ttgaaaaagt tggtttgtat atccctggtg gcactgccat tttaccaagt actgcattaa 2821 tgcttggtgt tccagcacaa gttgcccaat gtaaggagat tgtgtttgca tctccaccaa 2881 gaaaatctga tggtaaagtt tcacccgaag ttgtttatgt cgcagaaaaa gttggcgctt 2941 ccaagattgt tctagctggt ggtgcccaag ccgttgctgc tatggcttac gggacagaaa 3001 ctattcctaa agtggataag atcttgggtc caggtaatca atttgtgact gccgccaaaa 3061 tgtatgttca aaatgacact caagctctat gttccattga tatgccagct ggcccaagtg 3121 aagttttggt tattgccgat gaagatgccg atgtggattt tgttgcaagt gatttgctat 3181 cgcaagctga acacggtatt gactcccaag ttatccttgt tggtgttaac ttgagcgaaa 3241 agaaaattca agagattcaa gatgctgttc acaatcaagc tttacaactg ccacgtgtgg 3301 atattgttcg taaatgtatt gctcacagta cgatcgttct ttgtgacggt tacgaagaag 3361 cccttgaaat gtccaaccaa tatgcaccag aacatttgat tctacaaatc gccaatgcta 3421 acgattatgt taaattggtt gacaatgcag ggtccgtatt tgtgggtgct tacactccag 3481 aatcgtgcgg tgactattca agtggtacta accatacatt accaacctat ggttacgcta 3541 ggcagtacag tggtgccaac actgcaacct tccaaaagtt tatcactgcc caaaacatta 3601 cccctgaagg tttagaaaac atcggtagag ctgttatgtg cgttgccaag aaggagggtc 3661 tagacggtca cagaaacgct gtgaaaatca gaatgagtaa gcttgggttg ttcccaaagg 3721 atttccagta gattatttct aacttggaaa ccgaacacta acgaaaataa ttgtatatat 3781 acatatatat atcaaacaaa atacagtctt gaatgaatag agatacacta tgtaatgaat 3841 ggtaacgtaa aaattgtaat tttggattaa aagagaggta gtagcaagag tgggtatcaa 3901 atagcgatta ataaatgaat atccttattg tcatcacttc gaacgacgta agttaaattg 3961 gaaaattttt cactttttgg tcacctaaga aataagcagg aaaaagaaga gaacattgag 4021 aggatggtaa agcaagaggc atttagggcg aacgaactag gtaacagata acaacctcag 4081 atagagtgtt acgggatggg tattgaagac attagcgcca tgaagaacgg gtttatagtg 4141 gtgccgttca aattaccgga tcacaaggca ctacccaaaa gccaggaagc ttcgttgcat 4201 ttcatgtttg ctaaaagaca ccagagttca aattccaacg agtctgactg tttgtttttg 4261 gtcaaccctc cattattatc taacatagaa cgcatgaaga aatttgtcgg gcagctctgt 4321 gggaaatacg atacagtatc gcatgtagag gaactactat ataacgatga atttggatta 4381 catgaagtag atttatcggc attgacctcc gatctgatgt cctccactga ggtcaacgag 4441 aagagataca caccaagaaa cacggcgcta ttaaaatttg ttgatgctgc aagtataaat 4501 aactgctgga atgctttgaa aaaatactcg aatttgcatg ccaaacatcc aaatgaacta 4561 tttgaatgga catatacgac tccatcattc acaacttttg ttaacttcta caaaccactg 4621 gatattgatt atttgaaaga agatattcat acacatatgg caatttttga acagcgtgaa 4681 gctcaagcac aagaggatgt tcaaagttct atagtggatg aggatggatt cacattagtt 4741 gtaggaaaga a //