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From: sjhg9320@uxa.cso.uiuc.edu (Maximum Slackness )
Newsgroups: bionet.molbio.proteins
Subject: Re: protein design using computational methods
Keywords: protein folding, computational methods, molecular dynamics
Message-ID: <1991May17.200624.2349@ux1.cso.uiuc.edu>
Date: 17 May 91 20:06:24 GMT
References: <719@mixcom.COM> <2158@fcs280s.ncifcrf.gov> <1991May17.005953.12252@beaver.cs.washington.edu> <1991May17.121858.12141@murdoch.acc.Virginia.EDU>
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wrp@biochsn.acc.Virginia.EDU (William R. Pearson) writes:

>	I do not believe that there are any "well-known cases" of proteins
>of very similar sequence (>50% identity) folding into different
>conformations. I would be very interested in evidence to the contrary.

Consider ion channels such as the Axon Na+ Channel, the proton pore of
the V-Type ATPases, or lac permease.

Scott Howard
--

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