Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!wuarchive!uunet!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human mRNA for cytochrome P-450IID (clone pMP33) Message-ID: Date: 22 May 91 12:19:08 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 58 Approved: lear@genbank.bio.net Checksum: 35081 4 LOCUS HUMP450II 1315 bp ss-mRNA PRI 22-MAY-1991 DEFINITION Human mRNA for cytochrome P-450IID (clone pMP33) ACCESSION X16866 KEYWORDS cytochrome; cytochrome P-450; polymorphism. SOURCE Homo sapiens RNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 1315) AUTHORS Miles,S.J. JOURNAL Unpublished (1989) STANDARD full automatic REFERENCE 2 (sites) AUTHORS Gough,A.C., Miles,J.S., Spurr,N.K., Moss,J.E., Gaedigk,A., Eichelbaum,M. and Wolf,C.R. TITLE Identification of the primary gene defect at the cytochrome P450 CYP2D locus JOURNAL Nature 347, 773-776 (1991) STANDARD full staff_review COMMENT *source: tissue=liver; clone=pMP33; **map: chromosome=22; See for active P-450IID sequence. See also and for other sequences exhibiting P-450IID polymorphism. From EMBL 26 entry HSP450II; dated 28-MAR-1991. FEATURES Location/Qualifiers misc_feature 659..661 /note="ATG start codon" misc_feature 839..902 /note="insertion seqence corresponding to part of intron I" misc_feature 1227..1227 /note="single bp deletion compared with active P450IID sequence" BASE COUNT 293 a 418 c 336 g 268 t ORIGIN 1 gaattccgga agcctaactt cctccaacac aggaggaagg agagtgtccc ctgggtgctg 61 acccattgtg gggacgcatg tctgtccagt ccgtgtccaa caggagatcg acgacgtgat 121 agggcaggtg cggcgaccag agatgggtga ccaggctcac atgccctaca ccactgccgt 181 gattcacgag gtgcagcgct ttggggacat catccccctg agtgtgaccc atatgacatc 241 ccgtgacatc gaagtacagg gcttccgcat ccctaaggga acgacactca tcaccaacct 301 gtcatcggtg ctgaaggatg aggccgtctg gaagaagccc ttccgcttcc accccgaaca 361 cttcctggat gcccagggcc actttgtgaa gccggaggcc ttcctgcctt tctcagcagg 421 ccgccgtgca tgcctcgggg agcccctggc ccgcatggag ctcttcctct tcttcacctc 481 cctgctgcag cacttcagct tctccgtggc cgccggacag ccccggccca gccactctcg 541 tgtcgtcagc tttctggtga ccccatcccc ctacgagctt tgtgctgtgc cccgctagaa 601 tggggtacct agtccccagc ctgctcccta gccagaggct ctaatgtaca ataaagcaat 661 gtggtagttc caacttgggt cccctgctca cgccctcgtt gggagtcatc ctcctcaggg 721 caaccccatc ccctgcctca ttcctgctta ccccaccgcc tggccgcatt tgagacgggt 781 acgttgaggc tgagcagatg tcagttaccc ttgcccataa tcccatgtcc cccactgacc 841 caactctgac tgcccagatt ggtgacaagg actacattgt cctggcatgt ggggaagggg 901 ccagaatggg ctgactagag gtgtcagtca gccctggatg tggtggagag ggcaggactc 961 agcctggagg cccatatttc aggcctaact cagcccaccc cacatcaggg acagcagtcc 1021 tgccagcacc atcacaacag tcacctccct tcatatatga caccccaaaa tggaagacaa 1081 atcatgtcag ggagctatat gccagggcta cctcccaggg ctcagtcggc aggtgccaga 1141 acattccctg ggaaggcccc aggaaaaccc aggaccgagc caccgccctc agcctgtcac 1201 cttgtgtcca aaattggtgg gttcttggtc tcactgactt caagaatgaa gccgtggacc 1261 tcacggtgag tgttacagtt cttaaaaaaa aaaaaaaaaa aaaaaaaagg aattc //