Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!wuarchive!uunet!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human Ig germline H chain gene V-region (V79). Message-ID: Date: 23 May 91 12:00:52 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 65 Approved: lear@genbank.bio.net Checksum: 06378 4 LOCUS HUMIGHVM 626 bp ds-DNA PRI 23-MAY-1991 DEFINITION Human Ig germline H chain gene V-region (V79). ACCESSION X05713 KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain; immunoglobulin heavy chain subgroup vh-iv; variable region. SOURCE Human placentral DNA, clone V(79). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 626) AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T. TITLE A novel family of variable region genes of the human immunoglobulin heavy chain JOURNAL J. Mol. Biol. 195, 761-768 (1987) STANDARD simple staff_review COMMENT [1] enum. 1 to 626. Data kindly reviewed (24-NOV-1987) by HONJO T. EMBL features not translated to GenBank features: key from to description TRANSCR <1 >626 primary transcript of V-region of V region of heavy chain SITE 382 399 pot. complementarity determining region (cdr 1; AA 31 - 36) SITE 442 489 pot. cdr 2 (AA 51 - 66) IVS 586 >626 intron II SITE 588 594 recombination signal SITE 618 626 recombination signal FEATURES Location/Qualifiers CDS join(153..198,281..585) /partial /note="Ig H chain V-region (V79) precursor" sig_peptide join(153..198,281..291) /note="Ig H chain V-region signal peptide" exon <153..198 /note="Ig H chain V-region (V79) precursor, exon 1 /hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'" sig_peptide 153..198 /note="Ig H chain V-region signal peptide, exon 1" intron 199..280 /note="Ig H chain intron A" sig_peptide 281..291 /note="Ig H chain V-region signal peptide, exon 2" exon 281..>585 /note="Ig H chain V-region (V79) precursor, exon 2" mat_peptide 292..>585 /partial /note="Ig H chain V-region (V79)" BASE COUNT 141 a 180 c 172 g 133 t ORIGIN Chromosome 14. 1 catccctttt cacctcttta tacaaaggca ccacctacat gcaaatcctc acttaggcac 61 ccacaggaaa ccaccacaca tttccttaaa ttcagggtcc agctcacatg ggaaatactt 121 tctgagagct catgggcctc ctgcacaaga acatgaaaca cctgtggttc ttcctcctcc 181 tggtggcagc tcccagatgt gagtgtctca aggctgcaga catgggggta tgggaggtgc 241 ctctgatccc agggctcact gtgggtctct ctgttcacag gggtcctgtc tcaggtgcag 301 ctgcaggagt cgggcccagg actggtgaag cctccgggga ccctgtccct cacctgcgct 361 gtctctggtg gctccatcag cagtagtaac tggtggagtt gggtccgcca gcccccaggg 421 aaggggctgg agtggattgg ggaaatctat catagtggga gcaccaacta caacccgtcc 481 ctcaagagtc gagtcaccat atcagtagac aagtccaaga accagttctc cctgaagctg 541 agctctgtga ccgccgcgga cacggccgtg tattgctgtg cgagagacac agtgagggga 601 ggtgagtgtg agcccagaca caaacc //