Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!wuarchive!uunet!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human Ig germline H chain gene V-region (V58). Message-ID: Date: 23 May 91 12:00:50 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 67 Approved: lear@genbank.bio.net Checksum: 18363 4 LOCUS HUMIGHVL 623 bp ds-DNA PRI 23-MAY-1991 DEFINITION Human Ig germline H chain gene V-region (V58). ACCESSION X05716 KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain; immunoglobulin heavy chain subgroup vh-iv; variable region. SOURCE Human placental DNA, clone V(58). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 623) AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T. TITLE A novel family of variable region genes of the human immunoglobulin heavy chain JOURNAL J. Mol. Biol. 195, 761-768 (1987) STANDARD simple staff_review COMMENT [1] enum. 1 to 623. Data kindly reviewed (24-NOV-1987) by HONJO T. EMBL features not translated to GenBank features: key from to description TRANSCR <1 >623 primary transcript of V-region of heavy chain MSG 281 582 exon 2 SITE 379 396 pot. complementarity determining region 1 (cdr 1; AA 30 - 35) SITE 439 486 pot. cdr 2 (50 - 65) IVS 583 >623 intron II SITE 585 591 recombination signal SITE 615 623 recombination signal FEATURES Location/Qualifiers CDS join(153..198,281..582) /partial /note="Ig H chain V-region (V58) precursor" sig_peptide join(153..198,281..291) /note="Ig H chain signal peptide" exon <153..198 /note="Ig H chain V-region (V58) precursor, exon 1 /hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'" sig_peptide 153..198 /note="Ig H chain signal peptide" intron 199..280 /note="Ig H chain intron A" sig_peptide 281..291 /note="Ig H chain signal peptide" exon 281..>582 /note="Ig H chain V-region (V58) precursor, exon 2" mat_peptide 292..>582 /partial /note="Ig H chain V-region (V58)" BASE COUNT 145 a 175 c 165 g 138 t ORIGIN 1 cctccttttt cacctctccg tacaaaggca ccacccacat gcaaatcctt acttaagcac 61 ccacaggaaa tgactacaca tttccttaaa ttcagggtcc agctcacatg ggaagtgctt 121 tctgagagct catggacctc ctgcacaaga acatgaaaca cctgtggttc ttcctcctcc 181 tggtggcagc tcccagatgt gagtgtctca ggaatgcgga tatgaagaaa tggaagttgc 241 ctctgatccc agggctcact gtgggtttct ctgttcacag gggtcctgtc ccaggtgcag 301 ctacagcagt ggggcgcagg actgttgaag ccttcggaga ccctgtccct cacctgcgct 361 gtctatggtg ggtccgtcag tggttactac tggagctgga tccggcagcc cccagggaag 421 gggctggagt ggattgggta tatctattat agtgggagca ccaacaacaa cccctccctc 481 aagagtcgag ccaccatatc agtagacacg tccaagaacc agttctccct gaacctgagc 541 tctgtgaccg ccgcggacac ggccgtgtat tgctgtgcga gagacacagt gaggggaggt 601 gagtgtgagc ccagacaaaa acc //