Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!wuarchive!uunet!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human Ig germline H chain gene V-region (V2-1). Message-ID: Date: 23 May 91 12:00:48 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 66 Approved: lear@genbank.bio.net Checksum: 05890 4 LOCUS HUMIGHVK 628 bp ds-DNA PRI 23-MAY-1991 DEFINITION Human Ig germline H chain gene V-region (V2-1). ACCESSION X05715 KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain; immunoglobulin heavy chain subgroup vh-iv; variable region. SOURCE Human placental DNA, clone V(2-1). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 628) AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T. TITLE A novel family of variable region genes of the human immunoglobulin heavy chain JOURNAL J. Mol. Biol. 195, 761-768 (1987) STANDARD simple staff_review COMMENT [1] enum. 1 to 628. Data kindly reviewed (24-NOV-1987) by HONJO T. EMBL features not translated to GenBank features: key from to description TRANSCR <1 >628 primary transcript of V-region of heavy chain SITE 381 401 pot. complementarity determining region cdr 1 (AA 31 - 37) SITE 444 491 pot. cdr 2 (AA 52 - 67) IVS 588 >628 intron II SITE 590 596 recombination signal SITE 620 628 recombination signal FEATURES Location/Qualifiers CDS join(152..197,280..587) /partial /note="Ig H chain V-region (V2-1) precursor" sig_peptide join(152..197,280..290) /note="Ig H chain signal peptide" exon <152..197 /note="Ig H chain V-region (V2-1) precursor, exon 1 /hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'" sig_peptide 152..197 /note="Ig H chain signal peptide, exon 1" intron 198..279 /note="Ig H chain intron A" sig_peptide 280..290 /note="Ig H chain signal peptide, exon 2" exon 280..>587 /note="Ig H chain V-region (V2-1) precursor, exon 2" mat_peptide 291..>587 /partial /note="Ig H chain V-region (V2-1)" BASE COUNT 142 a 179 c 166 g 141 t ORIGIN Chromosome 14. 1 catccctttt cactgctccg tacaaacgca ccacccccat gcaaatcctc acttaggcgc 61 ccacaggaag ccaccacaca tttccttaaa ttcaggtcca actcataagg gaaatacttt 121 ctgagagctc atggatctca tgtgcaagaa catgaagcac ctgtggttct tcctcctgct 181 ggtggcggct cccagatgtg aatgtttcta ggatgcagac atggagatat gggaggtgcc 241 tctgatccca gggctcactg tgggtttttc tgttcacagg ggtcctgtcc cagctgcagc 301 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg 361 tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc cagcccccag 421 ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac tacaacccgt 481 ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccacttc tccctgaagc 541 tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagagac acagtgaggg 601 gaggtgagtg tgagcccaga cacaaacc //