Path: utzoo!utgpu!watserv1!watmath!att!news.cs.indiana.edu!sdd.hp.com!wuarchive!uunet!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human germline gene for the leader peptide and variable region of a Message-ID: Date: 27 May 91 12:26:37 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 83 Approved: lear@genbank.bio.net Checksum: 52679 5 LOCUS HUMIGK14 1970 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human germline gene for the leader peptide and variable region of a kappa immunoglobulin (subgroup V kappa I) ACCESSION Z00013 X00902 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin; signal peptide. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Zachau,H.G. JOURNAL Unpublished (1984) STANDARD full staff_review REFERENCE 2 (bases 1 to 1970) AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S., Klobeck,H.-G. and Zachau,H.G. TITLE Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type JOURNAL J. Mol. Biol. 176, 189-204 (1984) STANDARD full automatic REFERENCE 3 (bases 1771 to 1970) AUTHORS Straubinger,B., Pech,M., Muehlebach,K., Jaenichen,H.R., Bauer,H.G. and Zachau,H.G. TITLE Molecular footprints of human immunoglobulin gene evolution: a new sequence family JOURNAL Nucleic Acids Res. 12, 5265-5275 (1984) STANDARD full automatic COMMENT The sequence is designated Vd in refs. [1] and [2]; the gaps are not included into the numbering. From EMBL entry HSIGK14; dated 03-JAN-1991. FEATURES Location/Qualifiers CDS join(690..744,870..1165) /codon_start=690 misc_feature 562..576 /note="put. regulatory element pd" misc_feature 594..603 /note="put. regulatory element dc" promoter 636..643 /note="TATA-box" intron 745..869 /note="first intron" misc_feature 1168..1174 /note="heptanucleotide box" misc_feature 1860..>1970 /note="L-sequence region" BASE COUNT 578 a 443 c 413 g 536 t ORIGIN 1 tcgagcatta aagagactta tagctctgga caatgcagga actgtggatg tcatatgctt 61 taaggaatcc caatatcatc ttctttgtca atctgcagta aacctcttca gcttagactg 121 gtaataacat tggtttaggg ccattacaaa atgcttttga gaacatttta cttgctcatg 181 actaagtgtt cttttttact taaaaaaaga tcaatttcat gcttacaaaa atgtagtatg 241 tatgtcacaa agtatcgctc ccaactggaa caatttcaca gtgtgttgaa gacctgatag 301 ccccactctc taagacttta ttaagaattc tctacaaaca aggatattct cctacttatg 361 cccaatacgg cattgaaata tattattcca tctagttctc acaaccactt cgagatttgc 421 caataaatgc tcaaaaatgt acttggtaac aaaatatcct ttaggaagaa acattctctg 481 caggcaaatc taggtgccct ggtctgacct gggacactgg ggacactgcc cctgtgctga 541 gttactgaga taagccagcc acgcagctgt atccagcctg ccccaccccc tgccgatttg 601 cttgttccca gagcaccacc ccctgcccta aagacttctt aataggctgg tcacacctgt 661 gcaggagtca gtcccagtca ggacacagca tggacatgag ggtccccgct cagctcctgg 721 ggctcctgct gctctggctc ccaggtaagg aaggagaaca ctaggaattt actcagccca 781 gtgtgttccg tacagcctgg ctcttgaggg aagttctctt acaacatgat taattctatg 841 gacatttgtg tttatatttc caatctcagg tgccagatgt gacatccagt tgacccagtc 901 tccatccttc ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc gggccagtca 961 gggcattagc agttatttag cctggtatca gcaaaaacca gggaaagccc ctaagctcct 1021 gatctatgct gcatccactt tgcaaagtgg ggtcccatca aggttcagcg gcagtggatc 1081 tgggacagaa ttcactctca caatcagcag cctgcagcct gaagattttg caacttatta 1141 ctgtcaacag cttaatagtt accctcccac agtgttacaa acctgaacat aaacccccag 1201 ggaagcagac atgtgaggcc gggctgcccc agctgctcct cctgattcct ccatcagctg 1261 agagtgttcc tcagatgcag gcacactctg atggtgttgg tagaggggga tgtgaagtca 1321 cctctgcatc ccaatttctt tttctttctc agcaccaggt gcacagacat aacagttcct 1381 ctcctgattt aaaaaaggca gggatcatga cacctgagga gtctagttta tggcttcagt 1441 tggaattcag ttaacagaga agaagccact atagatatcc taagcaggaa ttgtcttgat 1501 acagagaaat agagtataaa ctatggaagt ctaaataaaa atatagagat gaatctcaaa 1561 tttcatgttt tatttgctaa gaaatatttg ctaaatgggg catacagaaa aactcaatgg 1621 tcttcaatat gttgaaagaa caaagagaag cttagagttt catgaaaaaa ggaaaatgtt 1681 acctattgct ctttgagaaa gtttattggc tccagaaaat tttgggagct ggcaagctca 1741 gaatggtaag cactgatgga caaactgaat cctagaatta tgttaaatta ttcagaagtt 1801 ggggttgaat ttgatttccg gttacaagag gccaaagcag tgaagcttgc agagaatctt 1861 gttagtgaaa tgccagggat ttggtgtaga tcctgctgct caccacatat aaaaccaatc 1921 actaagacaa caagtattgc caagaaacag gctttaatca ggtgctgcag //