Path: utzoo!utgpu!watserv1!watmath!att!news.cs.indiana.edu!sdd.hp.com!wuarchive!uunet!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human germ line gene for immunoglobulin kappa light chain leader Message-ID: Date: 27 May 91 12:26:39 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 102 Approved: lear@genbank.bio.net Checksum: 14456 6 LOCUS HUMIGK16 2375 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human germ line gene for immunoglobulin kappa light chain leader peptide and variable region (subgroup V kappa I) ACCESSION V01577 X00898 Z00011 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin; signal peptide; variable region. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Zachau,H.G. JOURNAL Unpublished (1984) STANDARD full staff_review REFERENCE 2 (bases 1 to 2375) AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S., Klobeck,H.-G. and Zachau,H.G. TITLE Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type JOURNAL J. Mol. Biol. 176, 189-204 (1984) STANDARD full automatic REFERENCE 3 (sites) AUTHORS Straubinger,B., Pech,M., Muehlebach,K., Jaenichen,H.R., Bauer,H.G. and Zachau,H.G. TITLE Molecular footprints of human immunoglobulin gene evolution: a new sequence family JOURNAL Nucleic Acids Res. 12, 5265-5275 (1984) STANDARD full staff_review COMMENT From EMBL entry HSIGK16; dated 07-NOV-1985. FEATURES Location/Qualifiers repeat_unit 865..956 /note="imperfect inverted repeat 1" misc_feature 1041..1055 /note="put. regulatory element pd" misc_feature 1073..1082 /note="put. regulatory element dc" promoter 1115..1122 /note="pot. TATA-box" CDS 1170..1224 /note="pot. signal peptide (aa -22 to -5) (1224 is 1st base in codon)" /codon_start=1170 intron 1225..1348 /note="pot. intron I" CDS 1349..1359 /note="pot. signal peptide (aa -4 to -1) (1349 is 2nd base in codon)" /codon_start=1349 CDS 1360..1644 /note="variable region" /codon_start=1360 misc_feature 1647..1653 /note="pot. V/J joining signal" misc_feature 1666..1674 /note="pot. V/J joining signal" repeat_unit 2113..2281 /note="imperfect inverted repeat 1'" misc_feature 2337..>2375 /note="L-sequence region" BASE COUNT 697 a 514 c 523 g 641 t ORIGIN 1 ctgcagcact gtgatttggc tcccctagtc aggcatcagt aaaattttgt ggagtcctag 61 gtggcagccc actgatgctg atgtagttgg atccactttc cctgctactg agtcaggctg 121 ggacattttt gggcacatta gagatatgag atataacgag tgcaaatccc tgtccagttt 181 catctggatc caagtgattt ctccatgtac ataggcaact gcttgataag agattcagtg 241 tctctttcct aaagcagtta acagggaggc tgttgcctgg gtcaggatga tttccccaat 301 cactgataaa aagtaaaaga ggaaagtgtc attgatggtg catggcaggg acatgctcca 361 tgcagtggtc accctcagta agagagatga actttgggaa ataatactga atggcagaaa 421 agaaggtaga ctatgaaggt gcccaaaaca agaataaggt gcaacccatt tagtgtctga 481 gtactataga gacctgtcgc tcttgataat tgtggatctg tgactgctgc atgcatcgag 541 aaaacacggt atcatctttg tgtatctata gtacatagtt tgatctcata ctggtaagaa 601 caatggcata acaccattac ctgatactta caaatgtatg taccatcatg tcaataaatt 661 ttatttttaa tttttttaca taggaacaat gttaaactca cagaaatgtt gcatgtatac 721 gacaaatacc cccttcccta gccggaatca tataagagtc ttttgaagac ttgagaattg 781 taccgtctaa cattttacta tgtgtttcct acaaacaaca atattctcct aaataatccc 841 catacaccaa tgaaatacat tagtccatca actcctgagg aatatttcaa atcgtcaaaa 901 agaaaccaaa aaatgttact cacaacaaaa tagttcccag tagaaacaca ttctctgcag 961 acaaatttgt gctaccctgg tcttacctgg gacacctggg gacactgagc tggtgctgag 1021 ttactgagat gagccagccc tgcagctgcg cccagcctgc cccatcccct gctcatttgc 1081 atgttcccag agcacagtct cctgacctga agacttatta acaggctgat cacaccctgt 1141 gcaggagtca gacccagtca ggacacagca tggacatgag ggtccccgct cagctcctgg 1201 ggctcctgct gctctggttc ccaggtaaga aaggagaaca ctaggattat actcggtcag 1261 tgtgctgagt actgctttac tattcaggga acttctctta cagcatgatt aattgtgtgg 1321 acatttgttt ttatgtttcc aatctcaggt tccagatgcg acatccagat gacccagtct 1381 ccatcttccg tgtctgcatc tgtaggagac agagtcacca tcacttgtcg ggcgagtcag 1441 ggtattagca gctggttagc ctggtatcag cagaaaccag ggaaagcccc taagctcctg 1501 atctatgctg catccagttt gcaaagtggg gtcccatcaa ggttcagcgg cagtggatct 1561 gggacagatt tcactctcac catcagcagc ctgcagcctg aagattttgc aacttactat 1621 tgtcaacagg ctaacagttt ccctcccaca gtgttaccaa cccgaacata aacccccagg 1681 gaagcagatg tgtgaagctg ggctgcccca gctgctcctc ctgatgcctc cattggctga 1741 gagtgttgct cagatgcagc cacactctga tggtgttggt agaggggtac gtgaaatcgc 1801 ctctgcaccc taattctttt ctctttctca gccccaactg cacagacata gcaatgcatc 1861 tcctgatttg ataaatacag agatcatgac acttgaggag tctagtttat ggcttcagct 1921 tgaattcata taacacagaa gaagccacta tagatattct aagcaggaat tgtcttaata 1981 cagagaatta aagtaaacta ctaaagtcaa aataaaatgt agagatgaat ctctaaattt 2041 aagttttatt tgcaaagaaa tatttgccag gtggggcata caggaaaact cagtggtctt 2101 caagatattg gaagaacgaa gagaaaatta gcattttatg aaaaagggaa aatgttacct 2161 gtggctcttt gagaaagttc attggcacta ggaagggttg ggagctggca agctcagact 2221 ggtaagcagt ggtggacaaa atgaatccta gaattatatc aagttatctc agaagttgtg 2281 gacaaatttg atttcaggtt acaataagcc aaagcagtga aggttgcaga gaattttgtt 2341 actgaaatgc cagggattca gtgaagactc tgcag //