Path: utzoo!utgpu!news-server.csri.toronto.edu!rpi!zaphod.mps.ohio-state.edu!wuarchive!uunet!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human germ line gene for immunoglobulin kappa light chain leader Message-ID: Date: 27 May 91 12:26:49 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 89 Approved: lear@genbank.bio.net Checksum: 27498 6 LOCUS HUMIGK9 2376 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human germ line gene for immunoglobulin kappa light chain leader peptide and variable region (subgroup V kappa I) ACCESSION V01576 X00899 Z00007 Z00011 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin; signal peptide; variable region. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 2376) AUTHORS Jaenichen,H.R. JOURNAL Unpublished (1984) STANDARD full automatic REFERENCE 2 (bases 1 to 2376) AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S., Klobeck,H.-G. and Zachau,H.G. TITLE Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type JOURNAL J. Mol. Biol. 176, 189-204 (1984) STANDARD full automatic COMMENT From EMBL entry HSIGK9; dated 06-JUL-1989. FEATURES Location/Qualifiers repeat_unit 866..957 /note="imp. inverted repeat 1" promoter 1115..1122 /note="pot. TATA-box" CDS 1170..1224 /note="pot. signal peptide (aa -22 to -5) (1224 is 1st base in codon)" /codon_start=1170 intron 1225..1349 /note="pot. intron I" CDS 1350..1360 /note="pot. signal peptide (aa -4 to -1) (1350 is 2nd base in codon)" /codon_start=1350 CDS 1361..1645 /note="variable region" /codon_start=1361 misc_feature 1648..1654 /note="pot. V/J joining signal" misc_feature 1667..1675 /note="pot. V/J joining signal" repeat_unit 2114..2282 /note="imp. inverted repeat 1'" BASE COUNT 698 a 512 c 519 g 647 t ORIGIN 1 ctgcagcact gtgatttggc tcccctagtc aggcatcagt aaaattttgt ggagtcctag 61 gtggcagccc actgatgctg atgtagttgg atccactttc cctgctacta agtcaggctg 121 ggacattttt gggcacatta gagatatgag atataacgag tgcaaatccg tgtccagttt 181 catctggatc caagtgattt ctccatgtac ataggcaact gcttgataag agattcagtg 241 tctctttcct aaagcagtta acagggaggc tggtgtctgg gtcaggatga tttccccaat 301 cactgataaa aagtaaaaga ggaaagtgtc attgatggtg catggcaggg acatgctcca 361 tgcagtggtc accctcagta agagagatga actttgggaa ataatattga atggcagaaa 421 agaaggtaga ctatgaaggt gcccaaaaca agaataaggt gcagcccatt tagtgtctga 481 gtactataga gacctgtcgc tcttgataat tgtggatctg tgactgctgc atgcatcaag 541 aaaacacggt atcatctttg tgtatctata gtacatagtt tgatcgcata ctggtaagaa 601 caatggcata acaccattac ctgatactta caaatgtatg taccatcatg tcaataaatt 661 ttatttttaa ttttttttac ataggaacaa tgttaaactc acagaaatgt tgcatgtata 721 tgacaaatac ccccttccct aaccggaatc atataagagt cttttgaaga cttgagaatt 781 gtaccgtcta acattttact atgtgtttcc tacaaacaac aatattctcc taaataatcc 841 ccatacacca atgaaataca ttagtccatc aactcctgag gaatatttca aatcgtcaaa 901 aagaaaccaa aaaatgttac tcacaacaaa atagttccca gtagaaacac attctctgca 961 gacaaatttg tgctaccctg gtcttacctg ggacacctgg ggacactgaa ctggtgctga 1021 gttactgaga tgagccagcc ctgcagctgt gcccagcctg ccccatcctc tgctcatttg 1081 catattccca gaacacaacc tcctgcctga agacttctta ataggctggt cacacttctt 1141 gcaggagtca gacccactca ggacacagca tggacatgat ggtccccgct cagctcctgg 1201 ggctcctgct gctctggttc ccaggtaaga aaggagaaca ctaggaattt actcagccca 1261 gtgtgctgag tactgcttta ctattcaggg aacttctctt acagcatgat taattgtgtg 1321 gacatttgtt tttatgtttc caatctcagg ttccagatgc gacatccaga tgacccagtc 1381 tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc atcacttgtc gggcgagtca 1441 gggtattagc agctggttag cctggtatca gcagaaacca gggaaagccc ctaagctcct 1501 gatctatgct gcatccagtt tgcaaagtgg ggtcccatca aggttcagcg gcagtggatc 1561 tgggacagat ttcactctca ccatcagcag cctgcagcct gaagattttg caacttacta 1621 ttgtcaacag gctaacagtt tcccttccac agtgttacca acccgaacat aaacccccag 1681 ggaagcagat gtgtgaagct gggctgcccc agctgctcct cctgatgcct ccattggctg 1741 agagtgttgc tcagatgcag ccacactctg atggtgttgg tagaggggta cgtgaaatcg 1801 cctctgcacc ctaattcttt tctctttctc agccccaact gcacagacat agcaatgcat 1861 ctcctgattt gataaataca gagatcatga cacttgagga gtctagttta tggcttcagc 1921 ttgaattcat ataacacaga agaagccgct atagatattc taagcaggaa tcgtcttaat 1981 acagagaatt aaagtaaact actaaagtca aaataaaatg tagagatgaa tctctaaatt 2041 taagttttat ttgcaaagaa atatttgcca ggtggggcat acaggaaaac tcagtggtct 2101 tcaagatatt ggaagaacga agagaaaatt agcattttat gaaaaaggga aaatgttacc 2161 tgtggctctt tgagaaagtt cattggctct aggaagggtt gggagctggc aagctcagac 2221 tggtaagcag tggtgggcaa aatgaatcct agaattatat caagttatct cagaagttgt 2281 ggacaaattt gatttcaggt tacaataagc caaagcagtg aaggttgcag agaattttgt 2341 tactgaaatg ccagggattc agtgaagacc ctgcag //