Path: utzoo!utgpu!watserv1!watmath!att!emory!wuarchive!uunet!stanford.edu!agate!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human germline gene for the leader peptide and variable region of a Message-ID: Date: 27 May 91 12:26:38 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 100 Approved: lear@genbank.bio.net Checksum: 15385 6 LOCUS HUMIGK15 2908 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human germline gene for the leader peptide and variable region of a kappa immunoglobulin (subgroup V kappa I) ACCESSION Z00014 X00901 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin; signal peptide; variable region. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Zachau,H.G. JOURNAL Unpublished (1984) STANDARD full staff_review REFERENCE 2 (bases 1 to 2908) AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S., Klobeck,H.-G. and Zachau,H.G. TITLE Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type JOURNAL J. Mol. Biol. 176, 189-204 (1984) STANDARD full automatic REFERENCE 3 (bases 2047 to 2749) AUTHORS Straubinger,B., Pech,M., Muehlebach,K., Jaenichen,H.R., Bauer,H.G. and Zachau,H.G. TITLE Molecular footprints of human immunoglobulin gene evolution: a new sequence family JOURNAL Nucleic Acids Res. 12, 5265-5275 (1984) STANDARD full automatic COMMENT The sequence is designated Ve in refs. [1] and [2]; the gaps are not included into the numbering. From EMBL entry HSIGK15; dated 03-JAN-1991. FEATURES Location/Qualifiers CDS join(957..1005,1131..1426) /codon_start=957 misc_feature 843..857 /note="put. regulatory element pd" misc_feature 875..877 /note="put. regulatory element dc defective (due to a deletion)" promoter 896..903 /note="TATA-box" intron 1006..1130 /note="first intron" misc_feature 1429..1435 /note="heptanucleotide box" misc_feature 2137..2619 /note="L-sequence region" BASE COUNT 885 a 592 c 638 g 793 t ORIGIN 1 ggatccagct gatttctcca tgtaagttgg caattgcttg ataagggatt gtctctttcc 61 taaagatgtt aacagggagg atggtgtctg ggtcaggatg atgtccctga taaaacgtaa 121 aagaagaaag tggcattgtt ggtgcatgac agggacatgc tccatgcagt ggtcaccctc 181 aataagagag aagaactttg gaaagtaata ctcaatgaca gaaaagaagg tagacaatga 241 aggtgcccaa aacaagaata aggtgaagtg aatttagtct ctgggtatta aagagacctg 301 tagctcttga taatggtgga tgtgtgagtg ctgcatgcat tgaggaaact cggtatcatc 361 tctctgtatc tgtagtaaat tgcttggtct tatagtggta agaacaatgg cataacacca 421 ttacctaata cttacaaata tgtatagcat catgtcaata aattttattt ttaatatttt 481 tagaaaggaa cagtgttaaa actcacagaa atgttgaagt ataggacaaa gtacctcctt 541 ccctaacccg aatcatatga gagtcttttg aagtcctgag aatcatactg tttaacattt 601 tactatgtat ttcctacaaa caagatattc caaataatcc ccatgtgcca atgaaataca 661 ttactccgtc gactcctgag gaatatttca aattttcaaa aaaatacata aaaaatgttt 721 ctcataacaa actactctcc agtagaaaca cattcaccac agacaaattt gtgctaccct 781 ggtctttcct gggacacctg gggatactga gctggtgctg agttactgag atgagccagc 841 cctgcagctg tgcccagtca gccccatccc ctgctcaacc tcctgccctg aagacttatt 901 aataggctgg acacacttca tgcaggagtc agaccctgtc aggacacagc atagacatga 961 gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtaag gaaggagaac 1021 actaggaatt tactcagccc agtgtgcttg gtacagcctg gcccttcagg gaagttctct 1081 tacaacatga ttaattgtat ggacatttgt ttttatgttt ccaatctcag gtgccagatg 1141 tgccatccgg atgacccagt ctccatcctc attctctgca tctacaggag acagagtcac 1201 catcacttgt cgggcgagtc agggtattag cagttattta gcctggtatc agcaaaaacc 1261 agggaaagcc cctaagctcc tgatctatgc tgcatccact ttgcaaagtg gggtcccatc 1321 aaggttcagc ggcagtggat ctgggacaga tttcactctc accatcagct gcctgcagtc 1381 tgaagatttt gcaacttatt actgtcaaca gtattatagt taccctccca cagtgttaca 1441 cacccaaaca aaaaccccca gggaagcaaa tgtgtgaggc tgggctgccc cagctgctcc 1501 tcctgatgcc tccatcgcct gagagtgttc ctcagatgca accacactct gatggtgttg 1561 gtagaggggg acctgaaatc acctctgcaa cccaattcct ttttctttgt aagccccagc 1621 tgcacagaca taacaatgcc tctcctgatt taataaaggc agagatcttg acacctaagg 1681 agtctagttt agggctttgg ttggaattca aataacagag aagaaaccac tatagatatt 1741 ctaagcagga aatgtcttaa tacagaaaat tagagtctaa actactgaag tctaaataaa 1801 atgtagagcg gaatctctaa atttcatgtt ttatttgcaa agaaatgttt gccaaattgg 1861 acacacagga aaactcagtg gtcttcaata tattggaagt acgaagagaa ggttagtgtt 1921 ttatgaaaaa gggaaaatat taccttttgc attttcagaa agttcactgg cactagtaag 1981 ggttgggagc tggcaagctc agactggtaa gcagtggtgg acaaagtgaa ttaggattca 2041 ctaattatat caattatatc aagttgtctc agaagttgca gttaaatgtg aattcaggtt 2101 acaagaagcc aaagcagtga aggttgcaga gaattttctt actaaaatgc caaggattca 2161 ttgtacaccc tgctgctcac cacgcagaaa gccaatctct aaaacaagta ttgccaagaa 2221 acaggcttta atcaggtact gcagccgagg agatgggaca ccatttgcga atgtatctcc 2281 ctgaccaact aaaattaaga ctttatataa cagggacaaa atgtgggaaa acaggaattt 2341 gggaggggta aggaagataa tttggtcaac aggaagcaag aggtcagtta tgcaatcata 2401 atgggtgaag gttctgatgt ctcagtgtcc ggattcagtg atatgtatgt ttcagctcct 2461 tgatagtatc tacgaggcct gatggttggt ttactgaaaa aagaactcag ataagacaaa 2521 tgtaactatc ttgagtttta agactggggg agtcaatttc tgtttattca aaaaaccata 2581 aaccttagtt ccatgggata acagggccta tttcaattgc attctagaaa caatatttta 2641 caccctgagt gcctttcccc actgggtgtc ttggctcttt tgggtataac aagaatgaac 2701 cgatgcctat gattaacgtt cagactacaa cctttcaaag ccaaggatat agtagtcagg 2761 aaagttgata ttagaagcag gattgaatgg cgctcactca gaaaacagaa tgcatctgcc 2821 cttgaagtat gggctatcta accatgtggt cctcagtcct gtctggaagc ttaggggtgg 2881 gagtgttgat gttctcagct tcctgcag //