Path: utzoo!utgpu!watserv1!watmath!att!emory!wuarchive!uunet!stanford.edu!agate!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human germline pseudogene for the leader peptide and variable Message-ID: Date: 27 May 91 12:26:45 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 69 Approved: lear@genbank.bio.net Checksum: 33111 4 LOCUS HUMIGK5 1157 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human germline pseudogene for the leader peptide and variable region of a kappa immunoglobulin (subgroup V kappa I) ACCESSION Z00003 X00747 KEYWORDS germline; immunoglobulin; kappa-immunoglobulin; pseudogene; variable region. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 1157) AUTHORS Jaenichen,H.R. JOURNAL Unpublished (1984) STANDARD full automatic REFERENCE 2 (bases 1 to 1157) AUTHORS Jaenichen,H.R., Pech,M., Lindenmaier,W., Wildgruber,N. and Zachau,H.G. TITLE Composite human V kappa genes and a model of their evolution JOURNAL Nucleic Acids Res. 12, 5249-5263 (1984) STANDARD full automatic COMMENT The sequence is designated V14 in refs. [1] and [2]; the start and stop positions of the leader peptide were defined according to sequence comparisons; several mutations render the leader gene segment inactive; the variable region gene segment is inactivated by a stop codon at the amino acid position 71. From EMBL entry HSIGK5; dated 13-JUN-1985. FEATURES Location/Qualifiers misc_feature 2..16 /note="put. regulatory element pd" misc_feature 34..43 /note="put. regulatory element dc" promoter 77..82 /note="TATA-box" CDS 130..184 /note="first exon (leader peptide, inactive) (184 is 1st base in codon)" /codon_start=130 intron 185..308 /note="first intron" CDS 309..604 /note="second exon (rest of L and variable region) (309 is 2nd base in codon)" /codon_start=309 misc_feature 607..613 /note="heptanucleotide box" BASE COUNT 289 a 292 c 289 g 287 t ORIGIN 1 ctgcagctgt gctcagcctg ccccatcccc tgctgatttg cctgttccta gagcacagcc 61 ccctgccctg aagacttttt ataggctggt cacacccggt gcaggagtca gccccagtca 121 ggacacagca cggatgcaag gtcccccact cagctcctgg ggctcctggt gctctggctg 181 ccaggtaagg aaggagaaca ctaggattat actcggtcag tgtgctcagt actgtctgga 241 acctcaggga agtcctctga taacatgatt aattgcaaga atatttgttt ttatgtttcc 301 aactgcaggt gccagatgtg acatccagat gacccagtct ccatcctccc tgtctgcatc 361 tgtaggaggc agagtcacca tcacttgccg ggcgagtcag ggcattagca ataatttaaa 421 ttggtatcag cagaaaccag ggaaaactcc taagcccctg atctatgctg catccagtct 481 gcaaagtggg attccctctc agttcagtga cagtggatct gggacagatt agactctcac 541 catcagcagc ctgcagcctg aagattttgc aacttattac tgtcaacaga gttacagtac 601 ccctcccaca gtgttgcaag tcataatata aaccccaagg aagcagatgt gtgaggctgg 661 gctgccccaa tgctccttct ggtgcctcta tctgctgagg gaagttctca aactcagtca 721 ggcttggaaa gtcattggga gattttccta gaggaggtca gggaggttcc tctgaaccct 781 aagcctcttt cgccctcatc cccagcagac aagatgtgac aatgcctgtc ctgactgaat 841 aaagaagaga gataagtcca gctgaggagt ctgtgttatg ggataatcgg aatttgtaca 901 gcaaaagaga agctattctc agtatttcaa ggagaaatta ttcaagttga ataaattaga 961 gtctaaacca cagtctttcc gaagcctatg gagtgttatt catgaagcag gtactagaca 1021 caggggattc tcaggtgcta cttcagaagc cagggtgcac ctgcccctgg tggtatgtgc 1081 tgaacaccat gtgatgatcc tcagtcctgt ctgggaagcc cagggctggg ggtgctgatg 1141 ctctcagctg cctgcag //