Path: utzoo!utgpu!watserv1!watmath!att!emory!swrinde!zaphod.mps.ohio-state.edu!wuarchive!uunet!stanford.edu!agate!bionet!root From: GenBank-Updates@genbank.bio.net Newsgroups: bionet.molbio.genbank.updates Subject: Human germ line gene for immunoglobulin kappa light chain leader Message-ID: Date: 27 May 91 12:26:48 GMT Sender: root@genbank.bio.net Distribution: bionet Lines: 97 Approved: lear@genbank.bio.net Checksum: 48702 6 LOCUS HUMIGK8 2470 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human germ line gene for immunoglobulin kappa light chain leader peptide and variable region (subgroup V kappa I) ACCESSION Z00006 X00900 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin; signal peptide; variable region. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 2470) AUTHORS Jaenichen,H.R. JOURNAL Unpublished (1984) STANDARD full automatic REFERENCE 2 (bases 1 to 2470) AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S., Klobeck,H.-G. and Zachau,H.G. TITLE Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type JOURNAL J. Mol. Biol. 176, 189-204 (1984) STANDARD full automatic COMMENT From EMBL entry HSIGK8; dated 06-JUL-1989. FEATURES Location/Qualifiers repeat_unit 442..533 /note="imperfect inverted repeat 1" unsure 582..582 /note="may be C or T" promoter 692..699 /note="pot. TATA-box" CDS 747..801 /note="pot. signal peptide (aa -22 to -5) (801 is 1st base in codon)" /codon_start=747 intron 802..927 /note="pot. intron I" unsure 824..824 /note="not determined" CDS 928..938 /note="pot. signal peptide (aa -4 to -1) (928 is 2nd base in codon)" /codon_start=928 CDS 939..1223 /note="variable region" /codon_start=939 misc_feature 1225..1232 /note="pot. V/J joining signal" misc_feature 1226..1232 /note="heptanucleotide box" misc_feature 1245..1253 /note="pot. V/J joining signal" repeat_unit 1688..1845 /note="imp. inverted repeat" BASE COUNT 729 a 517 c 523 g 699 t 2 others ORIGIN 1 ggatccactt cccctgctac tgagctaggc tgggacagtt ttgggcacat tagatatgtg 61 cgatataatg attgcaaatc atttccagtt tcatctgtat caaactgctt tctccatgta 121 cataggcatc atctctgtgg atctgtagta aattgcttga tcttatagtg gtaagaacaa 181 tggcataaca ccattaccga atactgacat gtatatatag catcatgtca ataaatttta 241 tttttgattt ttttagaaag gaacaatgtt aaactcacag aaatgttcca agtataggca 301 aagtaacccc ttccctaacc gggatcatat gagagtcttt tggagacctg ataatcatac 361 cgtctaacat tttattatat atttcctaca aacaagaata ttctcctaaa taatccccat 421 acaccaatga aatacattac tccatcaact cctgaggaat atttcaaatc gtcaaaaaaa 481 aactaaaaaa tgtctctcat aataaaatag ttcccagtag aaacacattc tctggagaca 541 aatttgtgct accctggtct tacctgggac acctggggac aytgaactgg tgctgagtta 601 ctgagatgag ccagccctgc agctgtgccc agcctgcccc atcctctgct catttgcata 661 ttcccagaac acaacctcct gccctgaaga cttcttaata ggctggtcac acttcttgca 721 ggagtcagac ccactcagga cacagcatgg acatgagggt ccccgctcag ctcctggggc 781 ttctgctgct ctggctccca ggtaaggaag gagaacacta gcantttact cagcccaggg 841 ggctcagtac agcctggcta ttcagggaaa ttctcttact acatgattaa ttgtgtggac 901 catttgtgtt tatgcttcca atctcaggtg ccagatgtgc catccagttg acccagtctc 961 catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg gcaagtcagg 1021 gcattagcag tgctttagcc tggtatcagc agaaaccagg gaaagctcct aagctcctga 1081 tctatgatgc ctccagtttg gaaagtgggg tcccatcaag gttcagcggc agtggatctg 1141 ggacagattt cactctcacc atcagcagcc tgcagcctga agattttgca acttattact 1201 gtcaacagtt taatagttac cctcacacag tgttacaaac ccgaacataa acccccaggg 1261 aagcagatgt gtgagactgg gctgccccag ctgcttctcc ttatgcctcc attggctgag 1321 agtgttcctc agatgcagcc acactctgat ggtgttggta gaggaggata tgagatcacc 1381 tctgcatccc aatttctttt tcttttctca gccccagctg cacagacata acaatgcctc 1441 tgctgattta ataaagatag agatcatgac acctgaagag tctagtttat ggctttggtt 1501 agaattcata taacagagaa gaagccatta tagatatcct aagcaggaat agtcttaata 1561 gatagaattg gagtctaaag tattgaagtc taaataaaat gtacagataa atttaatgtt 1621 ttatttgcta agaaattttt gccaaatggg gcatacagga aaactcaatg gtcttcaata 1681 tgttggaaga gcaaagagtt ttataaaaag ggaaattatt acctattgtt ctttgagaaa 1741 ttttgttggc tgtagtaagg gttgggagct ggcaagctca gactggtaag cagtggtggt 1801 caaactgaat cctagaatta tattaagtta tctcagaagt tgtgggtaaa tttgctttca 1861 ggttacaata agccaaagca gtgaagcttg cagagaattt tgttactgaa atgccaggga 1921 ttcagtatag atcctgcggc tcaccacaca gaaagccaat cactaagaca acaagtgttg 1981 ccaaagaaca ggctttaatc aggtgctgca gccgaggaga cgggacacca ttctcaaatg 2041 tatctccctg acaaaataaa ttaggggttt atatagcagg gaagaaatgt ggaaaacagg 2101 aattagagag gggtaaggaa gataatttag tcaacaggaa gctggaggtc agttaggcaa 2161 tcataatggg tgaagggtct gatgtctcac tgtccccatt cagtgatata taactttcag 2221 ctccttgata gtatctagag gcctgatggt tggtttcctg aaaaaagaac tcagattaac 2281 aaatgtaact accttgagtt ttaagactgg gggagtcagt ttctatgttt attcaaaaaa 2341 tcataaacat tagttccatg ggataatagg gcctatttca attgcattct tcagacaata 2401 ttttgcaccc tgagtggttt tccctcctgg tttcttggct ctgttgggta tgtcaagaat 2461 gaccgaattc //