Path: utzoo!utgpu!watserv1!watmath!att!news.cs.indiana.edu!bionet!root
From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Mouse (GAT-specific) subgroup II germline Ig V(H)10 gene related to
Message-ID: <May.27.05.39.28.1991.26176@genbank.bio.net>
Date: 27 May 91 12:39:29 GMT
Sender: root@genbank.bio.net
Distribution: bionet
Lines: 65
Approved: lear@genbank.bio.net
Checksum: 27994     4

LOCUS       MUSIG10VH     970 bp ds-DNA             ROD       27-MAY-1991
DEFINITION  Mouse (GAT-specific) subgroup II germline Ig V(H)10 gene related to
            anti-GAT Ab1 sequences
ACCESSION   X03571
KEYWORDS    germline; immunoglobulin; immunoglobulin heavy chain;
            immunoglobulin heavy chain subgroup VH-II; signal peptide;
            variable region.
SOURCE      Mus musculus DNA.
  ORGANISM  Mus musculus
            Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
            Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Schiff,C., Milili,M., Hue,I., Rudikoff,S. and Fougereau,M.
  TITLE     Genetic basis for expression of the idiotypic network: One unique
            Ig VH germline gene accounts for the major family of Ab1 and Ab3
            (Ab1') antibodies of the GAT system
  JOURNAL   J. Exp. Med. 163, 573-587 (1986)
  STANDARD  full automatic
COMMENT     EPD; 11151; Mm Ig VH10.
            
            The V(H)10 germline sequence is identical to the anti-GAT (Ab1)
            V(H) cDNA sequence of G8 Ca 1.7 <MMIGVK1>/<X00894>. See also
            <X03572> and <X03573>.
            
            From EMBL    entry MMIG10VH;  dated 10-JAN-1991.
FEATURES             Location/Qualifiers
     sig_peptide     join(445..490,570..580)
     mRNA            <491..490
                     /note="exon 1"
     misc_signal     342..351
                     /note="conserved element; pot. cell type specific
                     transcription control"
     promoter        367..374
                     /note="pot. TATA-box"
     intron          491..569
                     /note="intron I"
     mRNA            570..874
                     /note="exon 2"
     CDS             581..874
                     /product="H10 coding region"
                     /codon_start=581
     misc_feature    875..881
                     /note="7 bp recombination signal"
     misc_feature    905..913
                     /note="9 bp recombination signal"
BASE COUNT      272 a    211 c    217 g    270 t
ORIGIN
        1 ggccattatt atttaaatat atatgagaga agattgctaa ctctcataaa tgtattggtt
       61 ttttttttaa atttccagta agcgttatcc tcattgctac taccaccaat caattttttc
      121 actaagacaa gtgagtgtct caggttagga ttctatttta agattgagat attaggcttg
      181 atactacatc taaatggtct gtacatgtct cgaagaaagt tcttcagaca gagttaggac
      241 ttggatccca ggagttagga cttggactga ctcaggagga ctctagtttc ttcttctcca
      301 gctggaatgt ccttatgtaa gaaaagcctt gcctcatgag tatgcaaatc atgtgcgact
      361 gtgatgatta atatagggat atccacacca aacatcatat gagccctatc ttctctacag
      421 acactgaatc tcaaggtcct tacaatgaaa tgcagctggg ttatcttctt cctgatggca
      481 gtggttacag gtaaggggct cccaagtccc aaacttgagg gtccataaac tctgtgacag
      541 tggcaatcac tttgcctttc tttctacagg ggtcaattca gaggttcagc tgcagcagtc
      601 tggggcagag cttgtgaagc caggggcctc agtcaagttg tcctgcacag cttctggctt
      661 caacattaaa gacacctata tgcactgggt gaagcagagg cctgaacagg gcctggagtg
      721 gattggaagg attgatcctg cgaatggtaa tactaaatat gacccgaagt tccagggcaa
      781 ggccactata acagcagaca catcctccaa cacagcctac ctgcagctca gcagcctgac
      841 atctgaggac actgccgtct attactgtgc tagacacagt gttgcaacca catcctgagc
      901 gtgtcagaaa ccatagaact gcaggaagct gcctgagact gagatgacag acaatattat
      961 tgtgttagct
//