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From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human germline kappa-immunoglobulin variable region (V-kappa-II)
Message-ID: <May.30.05.13.13.1991.24435@genbank.bio.net>
Date: 30 May 91 12:13:13 GMT
Sender: root@genbank.bio.net
Distribution: bionet
Lines: 60
Approved: lear@genbank.bio.net
Checksum: 01214     4

LOCUS       HUMVKII       906 bp ds-DNA             PRI       30-MAY-1991
DEFINITION  Human germline kappa-immunoglobulin variable region (V-kappa-II)
            gene (Vc gene)
ACCESSION   X17265
KEYWORDS    immunoglobulin; immunoglobulin light chain; kappa immunoglobulin;
            kappa light chain.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
            Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and
            Zachau,H.G.
  TITLE     A large section of the gene locus encoding human immunoglobulin
            variable regions of the kappa type is duplicated.
  JOURNAL   J. Mol. Biol. 183, 291-299 (1985)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Klobeck,H.G.
  JOURNAL   Unpublished (1989)
  STANDARD  full automatic
COMMENT     *source: developmental stage=germline; tissue=placenta; *source:
            cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265>
            for other V kappa immunoglobulin genes.
            
            From EMBL    entry HSVKII;  dated 31-JUL-1990.
FEATURES             Location/Qualifiers
     mRNA            <688..687
                     /note="exon 2"
     intron          <1..377
                     /note="intron I"
     misc_feature    377..379
                     /note="stop codon (tga)"
     CDS             378..687
                     /note="leader peptide/variable region (103 AA) (378 is 2nd
                     base in codon) (687 is 2nd base in codon)"
                     /codon_start=378
     mutation        626..626
                     /note="frameshift mutation"
     misc_feature    690..696
                     /note="(non canonical) heptamer recombination signal"
BASE COUNT      242 a    219 c    210 g    235 t
ORIGIN
        1 ctgcagccac tgatgctaat atagttccat cccgccacct cccatgtgtg tcctgtcctc
       61 gtgttagatg tgtcttgtcc tccaggatgg ggcatatgat gtctagatct gtgagagtga
      121 ggaagattcc agaaggagca aggacatgta ctttagtgaa agctgtgaca cagaaagagg
      181 gggatgggat aggtgacttc tagaggccgg ctttgccttg caaatattgg ttctttttaa
      241 acctgtatgt tttgggagga ttaatcaaaa tcacacacac aaaaataatt gagcaaaaca
      301 taaataacag acagaaaatg attaaaatga ctcacaatgt ttgcacataa ccttgcactt
      361 ctctctcatt atttcatgat ccaatggaga tgctgcgaag acccaacctc cactctccct
      421 gcccatcacc cctggagagc cagcctccat ctcctgcagg tctagtcaca gcccccttca
      481 cagtaatgga tacatctatt tcaattggta cctacagaag ccaggccagc ctccttggct
      541 cccaatctat ttagtttcca atcacgaccc tggagtccca gacaagttca gtggcagtgg
      601 gtcggggaca gatttcatgc taaaatcagg aggatggatg ctgaggatgt tggggtttat
      661 tgctgccagc aaagtacaca ttatcctccc acaatggtag agtcttgaac acaaacctcc
      721 ccacttgctg tggcctagct gcccagatgt gctgtttctg tggagagcag gcactgtgga
      781 ttctcttaga tgcctaaaga agaagatgtt ggagaactca gagggcttgg tgcagctgag
      841 ggctcatgac cataaatttc tcggctacac ctcaggcatc acattttaag gtcccgtcag
      901 ctgcag
//