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From: GenBank-Updates@genbank.bio.net
Newsgroups: bionet.molbio.genbank.updates
Subject: Human germline kappa-immunoglobulin variable region (V-kappa-III)
Message-ID: <May.30.05.13.20.1991.24453@genbank.bio.net>
Date: 30 May 91 12:13:21 GMT
Sender: root@genbank.bio.net
Distribution: bionet
Lines: 60
Approved: lear@genbank.bio.net
Checksum: 46690     3

LOCUS       HUMVKIII      665 bp ds-DNA             PRI       30-MAY-1991
DEFINITION  Human germline kappa-immunoglobulin variable region (V-kappa-III)
            gene (Vg gene)
ACCESSION   X17264
KEYWORDS    immunoglobulin; immunoglobulin light chain; kappa immunoglobulin;
            kappa light chain.
SOURCE      Homo sapiens DNA.
  ORGANISM  Homo sapiens
            Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
            Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE   1  (sites)
  AUTHORS   Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and
            Zachau,H.G.
  TITLE     A large section of the gene locus encoding human immunoglobulin
            variable regions of the kappa type is duplicated.
  JOURNAL   J. Mol. Biol. 183, 291-299 (1985)
  STANDARD  full staff_review
REFERENCE   2  (bases 1 to 665)
  AUTHORS   Klobeck,H.G.
  JOURNAL   Unpublished (1989)
  STANDARD  full automatic
COMMENT     *source: developmental stage=germline; tissue=placenta; *source:
            cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265>
            for other V kappa immunoglobulin genes.
            
            From EMBL    entry HSVKIII;  dated 31-JUL-1990.
FEATURES             Location/Qualifiers
     mRNA            <132..131
                     /note="exon 1"
     promoter        22..29
                     /note="TATA-box"
     CDS             83..131
                     /note="leader peptide (AA 1-16) (131 is 1st base in
                     codon)"
                     /codon_start=83
     intron          132..300
                     /note="intron I"
     mRNA            301..596
                     /note="exon 2"
     CDS             301..596
                     /note="leader peptide/variable region (AA 17-115) (301 is
                     2nd base in codon)"
                     /codon_start=301
     misc_feature    599..605
                     /note="heptamer recombination signal"
BASE COUNT      174 a    183 c    146 g    162 t
ORIGIN
        1 ctgccctacc ttccagagcc catatcaatg cctgggtcag agctctgggg aggaactgct
       61 cagttaggac ccagacggaa ccatggaagc cccagcgcag cttctcttcc tcctgctact
      121 ctggctcaca ggtgagggga atatgaggtg tctttgcaca tcagtgaaaa ctcctgccac
      181 ctctgctcag caagaaatat aattaaaatt caaaatagat caacaatttt ggctctactc
      241 aaagacagtg ggtttgattt tgattacatg agtgcatttc tgttttattt ccaatttcag
      301 ataccaccgg agaaattgtg ttgacacagt ctccagccac cctgtctttg tctccagggg
      361 aaagagccac cctctcctgc agggccagtc agggtgttag cagctactta gcctggtacc
      421 agcagaaacc tggccaggct cccaggctcc tcatctatga tgcatccaac agggccactg
      481 gcatcccagc caggttcagt ggcagtgggc ctgggacaga cttcactctc accatcagca
      541 gcctagagcc tgaagatttt gcagtttatt actgtcagca gcgtagcaac tggcatccca
      601 cagtgattcc acatgaaaca aaaaccccaa caagaccatc agtgtttact agattattat
      661 accag
//