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Date: 28 Jun 91 10:32:51 GMT
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                             UNIVERSITY  OF  SURREY

                        SCHOOL  OF  BIOLOGICAL  SCIENCES

                          Molecular Microbiology Group

                      Ph.D. STUDENTSHIP (MAFF QUOTA AWARD)

             Use of gene probes and DNA fingerprinting to study the
                       epidemiology of bovine tuberculosis

        We  have recently described the use of a DNA probe  derived  from
        the insertion sequence IS986 for 'fingerprinting' M. tuberculosis
        isolates  in order to trace the routes of transmission  of  human
        tuberculosis.  The purpose of this project is to develop the  use
        of this and other gene probes for typing M. bovis isolates so  as
        to  ascertain the sources and routes of infection in  cattle  and
        deer, and also in wild animals (especially badgers).
             This  will provide training in a wide range  or  recombinant
        DNA  techniques  including  gene  cloning  and  sequencing,   the
        generation  of gene probes (using both isotopic and  non-isotopic
        labelling).  and nucleic acid hybridization. The benefit  of  the
        project  lies  in  the improved ability  for  control  of  bovine
        tuberculosis  that  can be derived from better  understanding  of
        routes of transmission. The project will run in conjunction  with
        an existing MAFF contract to develop a polymerase chain  reaction
        test   for  the  diagnosis  of  bovine  tuberculosis,  within   a
        substantial research team investigating the molecular biology  of
        mycobacteria.
             Enquiries/applications from candidates (UK resident) holding
        a  first or upper second class degree should be made AS  SOON  AS
        POSSIBLE,  to Dr J.W.Dale or Dr J.J.McFadden, (0483)  300800  ext
        2653/2671; (FAX: 0483 300374).

        Jeremy Dale
        Molecular Microbiology Group
        School of Biological Sciences
        University of Surrey
        Guildford
        Surrey GU2 5XH

        e-mail: MBY025@UK.AC.SURREY.SYSH


        June 27, 1991