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From: mark@elsie.UUCP
Newsgroups: net.bio,net.sci,net.usoft,net.wanted
Subject: Need UNIX-based Recombinate DNA Analysis Software
Message-ID: <1078@elsie.UUCP>
Date: Sat, 14-Jul-84 07:13:27 EDT
Article-I.D.: elsie.1078
Posted: Sat Jul 14 07:13:27 1984
Date-Received: Mon, 16-Jul-84 05:15:56 EDT
Organization: NIH-LEC, Bethesda, MD
Lines: 33
Xref: 93 83 8 1461

<>
We are looking for a recombinate DNA analysis package that will run under
UNIX.
		********************************
		* WE ARE WILLING TO PAY FOR IT *
		********************************

Our minimum requirements are as follows:
1.) Homology search: Given two sequences search for those sections of the
    DNA that are homologous to within a certain percentage.
2.) Restriction site search: Given one or more restriction enzymes, locate
    and map all restriction sites on a given vector or other DNA fragment.
3.) Sequence search within a data base: Give a sequence and a set of
    sequenced genes or/and DNA fragments find all sequences within the data
    base that contain the given site and map it.
4.) Shotgun analysis: Given a set of sequences from a shotgun DNA sequencing
    experiment (that is, where a gene or section of DNA is randomly sheared,
    cloned, and the randomly generated clones sequenced) find the areas of
    overlap and reconstruct the original (long) section of DNA.

We have so far looked at the Intelligenetics, IBI, and Battelle systems.
If anyone has experience with and/or options on these systems is hereby
invited to respond, privately or in public.

	****************************************************
	* ALL RESPONDENTS WILL BE INDIVIDUALLY THANKED!!!! *
	****************************************************

-- 
Mark J. Miller
NIH/NCI/DCE/LEC
UUCP:	decvax!harpo!seismo!umcp-cs!elsie!mark
Phone:	(301) 496-5688