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From: nose@nbires.UUCP (Steve Dunn)
Newsgroups: net.med
Subject: Thiazide diuretics & blood lipid level
Message-ID: <547@nbires.UUCP>
Date: Wed, 13-Nov-85 11:56:51 EST
Article-I.D.: nbires.547
Posted: Wed Nov 13 11:56:51 1985
Date-Received: Fri, 15-Nov-85 05:23:07 EST
Distribution: net
Organization: NBI,Inc, Boulder CO
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Steve Dyer in a recent article said that thiazide diuretics (Used to treat
hypertension) are associated with a rise of 5% in the cholesterol level,
10% in total triglycerides and 10% in low density lipoproteins. He also
says that the clinical signficance of this is unknown.
  First I wonder if anyone knows what the normal values for these items
are and what is considered too high.  This might help in guessing whether
5 or 10% rises are significant.
  Second I wonder if a person using thiazides should be tested for these
 things.
  Third if Steve has a reference for the increase blood lipid findings I'd
really like to get it.
  Fourth a friend of mine told me that she had heard that diuretic use had
recently been associated with an increased risk of heart attack even
when compared with no treatment at all. I don't believe it but I wonder
if there has been any finding like this.  It could be merely a distortion
of the findings Steve Dyer reported.
  Any answers would be greatly appreciated!

        -Steve "Brain? Sorry, wrong planet." Dunn