Relay-Version: version B 2.10 5/3/83; site utzoo.UUCP Posting-Version: version B 2.10.2 9/18/84; site bbncc5.UUCP Path: utzoo!watmath!clyde!burl!ulysses!gamma!epsilon!zeta!sabre!petrus!bellcore!decvax!ucbvax!ucdavis!lll-crg!seismo!harvard!bbnccv!bbncc5!sdyer From: sdyer@bbncc5.UUCP (Steve Dyer) Newsgroups: net.bio,net.med,net.motss Subject: Re: AIDS Research - Antiviral Drugs (Query)? Message-ID: <478@bbncc5.UUCP> Date: Fri, 13-Dec-85 19:31:02 EST Article-I.D.: bbncc5.478 Posted: Fri Dec 13 19:31:02 1985 Date-Received: Mon, 16-Dec-85 04:34:41 EST References: <894@ecsvax.UUCP> <835@h-sc1.UUCP> Distribution: net Organization: Bolt Beranek and Newman, Cambridge, MA Lines: 12 Xref: watmath net.bio:321 net.med:2978 net.motss:2342 This was asked a few months ago on net.bio. There are a few reverse transcriptase inhibitors being tested: one of them, suramin, is an old drug used for trypanosomiasis. Many of them (including suramin) have rather toxic side-effects, probably because their ability to inhibit enzymes isn't limited to viral reverse transcriptase. Also, most people with AIDS are already suffering the effects of successful viral attack; I guess you'd really like to treat with such drugs during the initial infection, which so far seems asymptomatic. -- /Steve Dyer {harvard,seismo}!bbnccv!bbncc5!sdyer sdyer@bbncc5.ARPA