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From: larry@kitty.UUCP (Larry Lippman)
Newsgroups: net.bio,net.misc
Subject: Re: Re: Does aspirin inhibit oxidative phosphorylation?
Message-ID: <704@kitty.UUCP>
Date: Mon, 13-Jan-86 12:04:00 EST
Article-I.D.: kitty.704
Posted: Mon Jan 13 12:04:00 1986
Date-Received: Sat, 18-Jan-86 07:14:39 EST
References: <1038@bnl44.UUCP> <688@kitty.UUCP> <2500@amdahl.UUCP>
Distribution: net
Organization: Recognition Research Corp., Clarence, NY
Lines: 27
Xref: watmath net.bio:339 net.misc:9123

> >     The major pharmacological action of aspirin is inhibition of various
> > prostagladins, resulting in:
> ... list of effects ...
>
> Not listed was another:  aspirin sensitizes the inner ear to nerve
> damage and deafness.  If you take lots of aspirin, don't go to loud
> places!! The length of time you need to be exposed and the loudness
> to which you must be exposed to cause deafness are reduced.
> Why?  I don't know.

        The effect of aspirin is that of producing "ringing" in the ears,
which is properly called tinnitus (not to be confused with tinea cruris :-) ).
Aspirin - and other drugs like quinine, streptomycin, neomycin - cause tinnitus
by irritating (and injuring) hair cells and nerve cells in the spiral ganglion
of Corti in the inner ear.
        I believe that tinnitus caused by aspirin and other drugs generally
disappears following discontinuance of the drug - unless excessive dosages
were used which caused irreversible nerve cell injury.  However, having this
type of tinnitus should not make the ear more susceptible to damage from loud
sound.

==>  Larry Lippman @ Recognition Research Corp., Clarence, New York        <==
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