Path: utzoo!utgpu!water!watmath!uunet!ig!daemon
From: SYEH@BIONET-20.ARPA
Newsgroups: bionet.molbio.evolution
Subject: Statistical significance of "PERCENT" homology.
Message-ID: <5701@ig.ig.com>
Date: 31 Mar 88 22:11:41 GMT
Sender: daemon@presto.ig.com
Lines: 14

From: Jack Kramer  <CMATHEWS.KRAMER@BIONET-20.ARPA>

Winston,

	Percent similarity can be used to imply homology (CELL 50:667 Aug 87)
as well as analogy.  The statistical significance of sequence similarity
has been extensively analysed. A couple of good places to start looking
are the appropriate chapters in von Heijne's "Sequence Analysis in Molecular
Biology", reviews and articles in Computer Applications in the Biosciences
(e.g. 3:1 Mar 87) and the Application of Computers to Research on Nucleic
Acids I, II and III supplements to NAR.

Jack
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