Path: utzoo!utgpu!water!watmath!uunet!ig!cunyvm.cuny.edu!CZJ%NIHCU.BITNET From: CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU Newsgroups: bionet.sci-resources Subject: (none) Message-ID: <8808032336.AA16164@presto.ig.com> Date: 3 Aug 88 18:47:54 GMT Sender: daemon@presto.ig.com Lines: 281 From the NIH Guide to Grants and Contracts 7/29/88. Included are the Table Of Contents and Items of Interest. Jim Cassatt Vol. 17, No. 24, July 29, 1988 NOTICES REVISED BOOKLET - NIH EXTRAMURAL PROGRAMS ..................(84/105)........ 1 National Institutes of Health Index: NIH EXTRAMURAL PROGRAMS MEETING - IRBs AT THE CROSSROADS: EXPANDING ROLES AND EXPANDED PROBLEMS ..........................................(108/158)....... 1 Public Responsibility in Medicine and Research Index: PUBLIC RESPONSIBILITY IN MEDICINE AND RESEARCH NATIONAL RESEARCH SERVICE AWARD (NRSA) STIPEND INCREASE ....(161/203)....... 2 Public Health Service Index: PUBLIC HEALTH SERVICE DATED ANNOUNCEMENTS (RFPs AND RFAs) SUPPORT SERVICES FOR EXPOSURE METHODS FOR PESTICIDES (RFP) ..(209/246)...... 2 National Cancer Institute Index: CANCER TRANSFUSION TRIAL TO PREVENT PLATELET ALLOIMMUNIZATION (RFA) ..(249/279)........ National Heart, Lung, and Blood Institute Index: HEART, LUNG, AND BLOOD MOLECULAR AND CELLULAR BIOLOGY OF CARDIAC INTERSTITIUM (RFA) ..(282/356).... 3 National Heart, Lung, and Blood Institute (888/1256) Index: HEART, LUNG, AND BLOOD ONGOING PROGRAM ANNOUNCEMENTS ROLE OF MARKET FORCES IN THE DELIVERY OF HEALTH CARE (PA) .....(362/567).... 4 National Center for Health Services Research and Health Care Technology Assessment Index: HEALTH SERVICES RESEARCH STUDIES OF THE PATHOPHYSIOLOGY OF NEUTROPENIAS AND THE MECHANISMS OF ACTION OF COLONY STIMULATING FACTORS (PA) ..................(570/712).... 7 National Institute of Allergy and Infectious Diseases Index: ALLERGY AND INFECTIOUS DISEASES PATHOPHYSIOLOGICAL MECHANISMS OF ENTEROPATHOGENIC VIRUSES (PA) ..(721/838).. 9 National Institute of Allergy and Infectious Diseases Index: ALLERGY AND INFECTIOUS DISEASES NOTICES REVISED BOOKLET - NIH EXTRAMURAL PROGRAMS P.T. 34, 44; K.W. 0710030, 0720005 National Institutes of Health The National Institutes of Health (NIH) has revised the NIH Extramural Programs Booklet, Funding for Research and Research Training, May 1988, (NIH Publication No. 88-33). This publication is a compendium of the scientific programs of the NIH components that award grants, cooperative agreements, and contracts. It indicates current areas of research emphasis, highlights the special interests of each awarding component, and identifies specific NIH offices that may be contacted for further information about particular programs, policies, and procedures. Institutional officials and investigators may obtain copies of this booklet by writing to: Office of Grants Inquiries Division of Research Grants National Institutes of Health Westwood Building, Room 449 Bethesda, Maryland 20892 Telephone: (301) 496-7441 MEETING - IRBs AT THE CROSSROADS: EXPANDING ROLES AND EXPANDED PROBLEMS P.T. 42; K.W. 1014002, 1014003, 0783005 Public Responsibility in Medicine and Research Public Responsibility in Medicine and Research (PRIM&R), a national organization concerned with ethical issues in research and medicine, is sponsoring a meeting entitled, "IRBs at the Crossroads: Expanding Roles and Expanded Problems." The meeting will be held on October 27-28, 1988, at the Boston Park Plaza Hotel, Boston, Massachusetts. The conference will look at the Federal Regulations on Research with Human Subjects, and will reassess their breadth as of their tenth anniversary approaches. Other issues to be examined at this meeting will include the problems of fraud and misconduct in medical research; the conduct of clinical trials in general, and subject payment for research drugs and devices in particular; IRB review of innovative therapies, including sequencing the genome, genetic testing and genetic research; input by pharmaceutical companies into the IRB review process; researcher responsibility in determining appropriate uses of confidentially acquired research data, including those derived from HIV-related projects; the use of cell lines and tissues, including fetal tissues; research with the elderly; the IRB's role in educating investigators and other institutional staff; reviewing research involving biohazards, and reviewing AIDS research - including vaccine development, etc. As in the past, the conference will include two specially designed educational series, one for committee administrators, and the second for new IRB members. This series serves as a basic orientation course for any new member, chair, or administrator. The meeting will consist of both plenary sessions and workshops, and will have a faculty of over thirty distinguished experts from the fields of IRB operation and administration, research and clinical practice, the Federal Government, the legal profession, and practicing ethicists. On October 26, 1988, Applied Research Ethics National Association (ARENA) will host its third annual meeting, also at the Park Plaza Hotel in Boston. This meeting will be held from 9 a.m. to 5 p.m., and will include a variety of speakers and workshops addressing issues pertinent to both IRB and IACUC administrators. For complete programs or further information please contact: PRIM&R 132 Boylston Street 4th Floor Boston, Massachusetts 02116 Telephone: (617) 423-4112 or (617) 423-1099 Vol. 17, No. 24, July 29, 1988 - Page 1 NATIONAL RESEARCH SERVICE AWARD (NRSA) STIPEND INCREASE P.T. 22, 44; K.W. 1014002, 0720005 Public Health Service Effective October 1, 1988, the annual stipend levels for all individuals receiving support through awards made under the National Research Service Award (NRSA) Act, P.L. 93-348 as amended under P.L. 99-158, will be as follows: Predoctoral Stipend All Years Current As of October 1, 1988 ---- $ 6,552 $ 8,500 Postdoctoral Stipend Years of Relevant Present Experience Stipend As of October 1, 1988 0 $15,996 $17,000 1 17,004 18,000 2 21,996 25,000 3 23,004 26,250 4 24,000 27,500 5 26,004 28,750 6 27,996 30,000 7 or more 30,000 31,500 Stipend level adjustments can be made only on the award date of the fellowship or the appointment date of the trainee. These stipend levels are effective only for awards made beginning with FY 1989 funds; no retroactive adjustments or supplementation of stipends with NRSA funds for awards made prior to October 1, l988, or with funds from FY 1988 is permitted. The new stipend levels are to be used in the preparation of future NRSA institutional training and individual fellowship applications. They will be administratively applied to all applications now in the review process. MOLECULAR AND CELLULAR BIOLOGY OF CARDIAC INTERSTITIUM RFA AVAILABLE: 88-HL-19-H P.T. 34; K.W. 0705015, 1002004, 1002008, 0765035 National Heart, Lung, and Blood Institute Application Receipt Date: January 16, 1989 BACKGROUND Congestive heart failure (CHF) afflicts approximately 2.3 million Americans and has become the most frequently specified DRG (diagnostic related groups). CHF has a variety of etiologies all of which result in loss of cardiac mechanical function. While the role of hypertrophy, necrosis, and altered function of heart muscle cells are the subject of considerable research, the role of changes in the cardiac interstitium has received relatively little attention. Yet, morphologists have shown that profound structural changes occur in the interstitium as a result of ischemia, hypertrophy, or viral infection. In the past, these changes have generally been regarded as passive phenomena and reparative processes. Accumulating evidence now suggests that remodeling of the connective tissue framework of the heart may contribute to the disease process and the appearance of heart failure. A major component of the connective tissue framework of the heart is fibrillar collagen which appears to be secreted by cardiac fibroblasts residing in the interstitium. OBJECTIVES AND SCOPE The overall goal is to encourage research focused on the molecular and cellular biology of the cardiac interstitium and on mechanisms involved in the initiation and control of changes which occur as a result of physiologic and pathologic stimuli. Examples of appropriate projects are: expression and regulation of cardiac fibroblast collagen genes and collagenase genes; interactions between fibroblasts and other cells and components of the cardiac interstitium; and factors involved in the migration and proliferation of cardiac fibroblasts. Vol. 17, No. 24, July 29, 1988 - Page 3 MECHANISM OF SUPPORT The support mechanism for this program will be the traditional, individual research grant. All current policies and requirements that govern the research grant programs of the National Institutes of Health will apply to grants awarded under this RFA. Awards will be made to foreign institutions only for research of very unusual merit, need, and promise, and in accordance with Public Health Service policy governing such awards. The financial plans for fiscal year 1989 include $1,500,000 for the total costs of this program, award of grants pursuant to this RFA is contingent upon receipt of funds for this purpose. It is anticipated that up to ten grants will be awarded under this program. The specific amount to be funded will, however, depend on the merit and scope of the applications received and on the availability of funds. REVIEW PROCEDURES All applications submitted in response to this RFA will be evaluated for scientific and technical merit by an initial review group, which will be convened for this purpose, by the Division of Extramural Affairs, NHLBI. METHOD OF APPLYING Potential applicants should write or phone the individual listed below for the full RFA document, which includes instructions for the submission of applications: Constance Weinstein, Ph.D. Cardiac Diseases Branch Division of Heart and Vascular Diseases National Heart, Lung and Blood Institute, NIH Federal Building, Room 3C06 7550 Wisconsin Avenue Bethesda, Maryland 20892