Path: utzoo!utgpu!water!watmath!clyde!att!osu-cis!tut.cis.ohio-state.edu!mailrus!nrl-cmf!cmcl2!lanl!beta!dd
From: dd@beta.lanl.gov (Dan Davison)
Newsgroups: sci.bio
Subject: Re: Restriction Mapping and Software and Theory...
Summary: Michael Waterman
	 Eric Lander
Keywords: DNA and maps...
Message-ID: <21800@beta.lanl.gov>
Date: 4 Oct 88 03:23:24 GMT
References: <21491@cornell.UUCP>
Organization: Los Alamos National Laboratory
Lines: 33

In article <21491@cornell.UUCP>, wayner@svax.cs.cornell.edu (Peter Wayner) writes:
> Does anyone have any references on software to do restriction
> mappings of DNA? 

At what level?  Taking a restriction digest and assembling a unique
map (if possible)? Prediction on what fragments will result from genomic
cloning and sequencing?

>Has anyone looked at the problem mathematically?

Depends on your question.  For assembly of restriction maps, there have
been a few attempts to analyze mathematically; there were some papers
by Mike Waterman in Nucleic Acids Research a few years ago.

Mike and Eric (Erik?) Lander have an article in a issue of Genomics
earlier this year on the subject.

> Has anyone looked at the problem from the standpoint of a 
> computer scientist?

Since the problem you are asking about is unclear, I can't answer this
exactly.  The answer is yes for both cases but to different degrees.

> If anyone has any references, I would appreciate an 
> answer. 
> Peter Wayner

Send me e-mail that goes to my office (dd@lanl.gov) and I will get them
out.
-- 
dan davison/theoretical biology/t-10 ms k710/los alamos national laboratory
los alamos, nm 875545/dd@lanl.gov (arpa)/dd@lanl.uucp(new)/..cmcl2!lanl!dd
"I think, therefore I am confused"