Path: utzoo!utgpu!water!watmath!uunet!mcvax!enea!kth!draken!bmc1!sys_ms
From: sys_ms@bmc.uu.se (Mats Sundvall)
Newsgroups: bionet.molbio.gene-express
Subject: Profile searching on nucleic acid sequences
Message-ID: <3954@bmc.uu.se>
Date: 12 Oct 88 18:38:13 GMT
Organization: Biomedical Center, University of Uppsala, Sweden
Lines: 19


In the GCG package of computerprograms from U. of Wisconsin there is a couple
of programs that deals with profilesearching. In the documentation they
talk about the increased sensitivity of the method when used to search
for similar protein sequences.

My question is if anyone can comment on if the profile analysis is suitable
to use on nucleic acid sequences as well. Is it possible to compile profiles
for parts of promoter or enhancer sequences and use them as search probes
to find related sequences.

Has anyone done something like this?

-- 
		Mats Sundvall			

		Biomedical Center		+46/18174583
		University of Uppsala		Mats.Sundvall@BMC.UU.SE
		Sweden				psi%24020019700620::MATS