Path: utzoo!utgpu!watmath!uunet!bionet!nihcu.bitnet!CZJ From: CZJ@nihcu.bitnet Newsgroups: bionet.sci-resources Subject: (none) Message-ID: <8812101423.AA02472@net.bio.net> Date: 10 Dec 88 14:17:08 GMT Sender: daemon@NET.BIO.NET Lines: 196 Attached is the Table of Contents and Items of Interest from the NIH Guide to Grants and Contracts dated 12/02/88. Jim Cassatt ------------------------- Vol. 17, No. 40, December 2, 1988 NOTICES NIH REGIONAL WORKSHOPS ON IMPLEMENTATION OF THE PHS POLICY ON HUMANE CARE AND USE OF LABORATORY ANIMALS ............(84/168)........... 1 National Institutes of Health Index: NATIONAL INSTITUTES OF HEALTH CHANGE IN ELIGIBILITY REQUIREMENTS ......................(171/186).......... 2 National Institute on Aging Index: AGING NOTICE OF AVAILABILITY ...........................(260/351, 1124/2198)...... 2 National Institute on Diabetes and Digestive and Kidney Diseases Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES MAILABILITY OF ETIOLOGIC AGENTS ...........................(354/506)........ 2 National Institutes of Health Alcohol, Drug Abuse, and Mental Health Administration Index: NATIONAL INSTITUTES OF HEALTH DATED ANNOUNCEMENTS (RFPs AND RFAs) WORKSITE HEALTH PROMOTION INTERVENTIONS (RFA) ......(260/351, 1124/2198).... 3 National Cancer Institute Index: CANCER PROGRAM PROJECTS ON MECHANISMS OF IMMUNOLOGIC DISEASES (RFA) ..(354/506).... 4 National Institute of Allergy and Infectious Diseases (2201/2522) Index: ALLERGY AND INFECTIOUS DISEASES PROGRAM PROJECTS ON THE BIOLOGY OF THE IMMUNE SYSTEM (RFA) ...(509/628)..... 6 National Institute of Allergy and Infectious Diseases (2525/2777) Index: ALLERGY AND INFECTIOUS DISEASES ONGOING PROGRAM ANNOUNCEMENTS MECHANISMS AND MANAGEMENT OF PEDIATRIC LIVER DISEASES ......(644/814)....... 8 National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Child Health and Human Development Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES CHILD HEALTH AND HUMAN DEVELOPMENT MATERNAL AND PATERNAL DRUG ABUSE AND ITS EFFECTS ON OFFSPRING ..(817/899)...10 National Institute on Drug Abuse Index: DRUG ABUSE RESEARCH GRANTS RELATED TO BATTEN DISEASE AND OTHER NEURONAL CEROID LIPOFUSCINOSES ........................................(902/1054)....11 National Institute of Neurological and Communicative Disorders and Stroke Index: NEUROLOGICAL AND COMMUNICATIVE DISORDERS AND STROKE PROGRAM PROJECTS ON THE BIOLOGY OF THE IMMUNE SYSTEM RFA AVAILABLE: 89-AI-04 P.T. 34; K.W. 0705040, 0710070, 1002004, 1002008, 0710065, 0790000 National Institute of Allergy and Infectious Diseases Letter of Intent Receipt Date: April 17, 1989 Application Receipt Date: June 14, 1989 BACKGROUND INFORMATION The Immunobiology and Immunochemistry Branch of the Allergy, Immunology and Transplantation Program* of the National Institute of Allergy and Infectious Diseases (NIAID), supports fundamental studies on the structure and function of the immune system to gain an understanding of immune response mechanisms at their basic cellular and molecular levels as they function in health and disease. Program Projects on the Biology of the Immune System represent an award mechanism which the Branch employs to meet this objective. They are intended to support integrated, multidisciplinary, basic studies of immunologically-functional lymphocytes and other relevant cell populations. Twelve such program projects are currently funded although support for one is scheduled to conclude in 1990. In fiscal year 1990 NIAID plans to award at least one Program Project on the Biology of the Immune System. This request for applications is intended to encourage the development of proposals from collaborating investigators and to coordinate the submission and review of new and renewal program project applications. *Formerly Immunology, Allergic and Immunologic Diseases Program RESEARCH GOALS AND SCOPE The goal of these Program Projects is the attainment of a complete understanding of the structure and function of the immune system and its products, its interaction with other body systems, and full knowledge of the genetic and other factors which regulate its development and function. An ultimate practical application of this information is the use of selected cloned cells of the system, or their products, for the clinical care or reconstitution of immunodeficient individuals, to alleviate allergic states, to provide resistance to life-threatening infections and to correct aberrant or defective immunoregulatory mechanisms. The scope of these program projects includes studies of every facet of the immune response, ranging from the initial step of antigen recognition to the final elaboration of immunologically distinctive products of specific immunocytes. Research currently supported by this mechanism was designed to expand knowledge of the morphologic and functional heterogeneity of lymphocyte populations and develop the capability for identification and selection of Vol. 17, No. 40, December 2, 1988 - Page 6 lymphocyte subpopulations, with specific immune reactivity or molecular composition, for use in somatic hybridization and selective production of specific, biologically active, lymphocyte products. Similar studies of macrophages, other accessory and effector cells, and networks of cells and molecules that affect the activation, differentiation and regulation of cells of the immune system are appropriate. Projects that involve improving the efficiency or scale of preparing and selecting hybridomas and other relevant cell lines for defined purposes, and projects designed to modify genes encoding immunologically relevant macromolecules to improve their biological efficiency, or diagnostic and therapeutic utility, are encouraged. MECHANISM OF SUPPORT Program project grants are awarded to an institution on behalf of a program director for the support of a broadly-based, multidisciplinary, long-term research program which has a specific major objective or basic theme. A program project generally involves the organized efforts of groups of investigators who conduct research projects related to the overall program objective. The grant can provide support for the projects and for certain core resources shared by individuals where the sharing facilitates the total research effort. Each component project, supported under a program project grant, is expected to contribute and be directly related to a common theme. The projects should demonstrate an essential element of unity and interdependence. METHOD OF APPLYING Before preparing an application, the prospective applicant should request a copy of the Information Brochure: Program Projects and Center Grants, NIAID, from: Dr. Nirmal K.Das Executive Secretary Allergy, Immunology and Transplantation Research Committee National Institute of Allergy and Infectious Diseases National Institutes of Health Westwood Building, Room 3A-07 Bethesda, Maryland 20892 Telephone: (301) 497-7966 STAFF CONTACT For further programmatic information and a copy of the detailed RFA, contact: Joseph F. Albright, Ph.D. Chief, Immunobiology and Immunochemistry Branch, AITP National Institute of Allergy and Infectious Diseases Westwood Building, Room 757 National Institutes of Health Bethesda, Maryland 20892 Telephone: (301) 496-7551 Telefax Number: (301) 480-3780 Prospective applicants are encouraged to submit a one-page letter of intent that includes a descriptive title and identification of any other participating institutions. The Institute requests such letters by April 17, 1989, for the purpose of providing an indication of the number and scope of applications to be received. A letter of intent is not binding. It will not