Path: utzoo!utgpu!watmath!uunet!bionet!nihcu.bitnet!CZJ From: CZJ@nihcu.bitnet Newsgroups: bionet.sci-resources Subject: (none) Message-ID: <8812230126.AA23028@net.bio.net> Date: 23 Dec 88 01:19:44 GMT Sender: daemon@NET.BIO.NET Lines: 511 Attached are the Table of Contents and Items of Interest from the NIH Guide to Grants and Contracts 12/23/88. Best Wishes for the holiday season Jim Cassatt Vol. 17, No. 43, December 23, 1988 NOTICES "OTHER SUPPORT" IN PHS GRANT APPLICATIONS ..............(84/109)............. 1 National Institutes of Health Index: NATIONAL INSTITUTES OF HEALTH "OTHER SUPPORT" IN NIH R&D CONTRACT PROPOSALS ..........(112/130)........... 1 National Institutes of Health Index: NATIONAL INSTITUTES OF HEALTH NUCLEIC ACID AND PROTEIN SEQUENCE WORKSHOP ANALYSIS FOR BIOMEDICAL RESEARCHERS .................................(133/184)............ 1 Division of Research Resources Index: RESEARCH RESOURCES NIH/FDA REGIONAL WORKSHOPS - PROTECTION OF HUMAN SUBJECTS ...(187/272)...... 2 National Institutes of Health Food and Drug Administration Index: NATIONAL INSTITUTES OF HEALTH, FOOD AND DRUG ADMINISTRATION DATED ANNOUNCEMENTS (RFPs AND RFAs) COCHLEAR RE-IMPLANTATION: HISTOPATHOLOGY ANNOUNCEMENTS (RFP) ...(278/318).. 3 National Institute of Deafness and Other Communication Disorders Index: DEAFNESS, COMMUNICATION DISORDERS PRESOLICITATION: COLLABORATIVE STUDIES FOR DIAGNOSTIC CENTERS FOR PSYCHIATRIC LINKAGE STUDIES (RFA) ..........................(321/428).... 4 National Institute of Mental Health Index: MENTAL HEALTH COORDINATING CENTER FOR COLLABORATIVE STUDIES ON THE GENETICS OF ALCOHOLISM (RFA) ......................(431/541, 1204/2282)...... 5 National Institute on Alcohol Abuse and Alcoholism Index: ALCOHOL ABUSE, ALCOHOLISM EXTRAMURAL RESEARCH GROUPS FOR COLLABORATIVE STUDIES ON THE GENETICS OF ALCOHOLISM (RFA) ......................(544/663, 2285/3350)..... 6 National Institute on Alcohol Abuse and Alcoholism Index: ALCOHOL ABUSE, ALCOHOLISM AIDS THERAPIES TARGETED TO PREVENT THE ESTABLISHMENT OF LATENCY OR SUPPRESS PROVIRUS INDUCTION (RFA) ..............(666/780, 3353/3688)...... 8 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES DEVELOPMENT OF SMALL ANIMALS EXPRESSING HUMAN IMMUNODEFICIENCY VIRUS GENES AS MODELS FOR THERAPY (RFA) ...........(783/896, 3691/4026)...... 9 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES PROGRAM PROJECTS IN TRANSPLANTATION IMMUNOLOGY (RFA) .(899/1008, 4029/4337)..11 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES LONG TERM CULTIVATION AND PRESERVATION OF HUMAN IMMUNOCYTE PROGENITORS (RFA) .................................(1011/1145, 4340/4495)....12 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES ERRATUM SPECIALIZED CENTERS FOR NURSING RESEARCH (RFA) EXPLORATORY CENTERS FOR NURSING RESEARCH (RFA) .........(1151/1176)..........14 National Center for Nursing Research Index: NURSING RESEARCH CLINICAL INVESTIGATOR AWARD IN GERIATRIC OTOLARYNGOLOGY (K08) (PA) ..........14 National Institute on Aging (1179/1191) National Institute of Neurological and Communicative Disorders and Stroke Index: AGING, NEUROLOGICAL AND COMMUNICATIVE DISORDERS, STROKE NOTICES "OTHER SUPPORT" IN PHS GRANT APPLICATIONS P.T. 34; K.W. 1014002, 1014006 National Institutes of Health The PHS 398 (Rev. 9/86) and PHS 2590 (Rev. 9/86) grant application forms include a section on OTHER SUPPORT, where applicants are expected to list all, including both Federal and non-Federal, active support and pending and planned requests for support of research and research-related activities by all key personnel listed for each application. This information is important to PHS review-award processes to help evaluate the compatibility of application requests with investigators' capabilities and responsibilities, and eliminate unwarranted duplication of support for investigators' efforts. Application instructions emphasize the requirement for complete, accurate, and reliable information. In signing the face page of the application the principal investigator/program director and the applicant institution official certify that the application information is accurate and complete. Applicants are reminded of the necessity to provide the full and reliable information requested. As noted in the instructions, "Incomplete, inaccurate, or ambiguous information about OTHER SUPPORT could lead to delays in review of the application." Further, applicants should be cognizant that serious consequences could result if failure to provide complete and accurate information be construed as an attempt to mislead PHS agency advisory groups and staff in their review and award responsibilities. "OTHER SUPPORT" IN NIH R&D CONTRACT PROPOSALS P.T. 34; K.W. 1014002, 1014006 National Institutes of Health Documentation required in Section J of the NIH uniform Request for Proposal format includes Standard Form 1411, Contract Pricing Proposal Cover Sheet, which instructs offerors to identify any contracts or subcontracts they have been awarded "for the same or similar items" within the past three years. Additionally, offerors are required to provide a Summary of Related Activities, identifying all active federal contracts, cooperative agreements, grants, and commercial agreements, and submitted proposals, including actual and proposed levels of effort for all key individuals in the proposal to NIH. As for PHS grant applications, mentioned above, offerors should be aware that serious consequences could result if their failure to provide complete and accurate information be construed as an attempt to mislead agency advisory groups and staff in their review and award responsibilities. NUCLEIC ACID AND PROTEIN SEQUENCE WORKSHOP ANALYSIS FOR BIOMEDICAL RESEARCHERS P.T. 42; K.W. 0755045, 0760070 Division of Research Resources Application Receipt Date: February 10, 1989 The Pittsburgh Supercomputing Center (PSC) is conducting a three-day workshop on "Nucleic Acid and Protein Structure Analysis," March 27-29, 1989. This workshop is funded by a cooperative agreement from the Division of Research Resources' Biomedical Research Technology (BRT) Program of the National Institutes of Health (NIH). The workshop will familiarize biomedical researchers with computational methods and provide practice in applying supercomputing resources to problems of concern in molecular sequence analysis. Practical experience on the Pittsburgh Supercomputing Center's Cray Y-MP/832 will be gained in: (1) the recognition of subsequences representing signals structural patterns and statistical properties of gene and protein sequences; (2) comparisons of sequences for detection of local simularities between pairs and sequences; (3) multiple sequence alignments; and (4) prediction of secondary structure from primary sequence information. Programs such as the IDEAS and Wisconsin packages as well as stand alone programs will be illustrated. Participants are encouraged to bring their own sequence analysis problems. Workshop Vol. 17, No. 43, December 23, 1988 - Page 1 leaders: Michael Waterman, University of Southern California; Ruth Nussinov, Tel Aviv University; and Jacob B. Maizel, Jr., National Cancer Institute. This three-day workshop will include an optional half-day session the morning of March 27 led by PSC staff members. Topics to be covered during the optional session include VAX, VMS, and UNICOS, the Cray version of the AT&T System V Unix operating system. Travel, meals, and hotel accommodations are covered for U.S. academic participants under the grant. A limited number of openings for industry-based biomedical researchers may be available for a fee of $1,000. Enrollment is limited to 20 participants. THE DEADLINE FOR SUBMISSION OF APPLICATIONS IS FEBRUARY 10, 1989. For application forms and further information, call or write to: Cherolyn Brooks User Services Pittsburgh Supercomputing Center 4400 Fifth Avenue Pittsburgh, Pennsylvania 15213 Telephone: (412) 268-5206, or 1-800-222-9310 (Pennsylvania) 1-800-221-1641 (outside Pennsylvania) NIH/FDA REGIONAL WORKSHOPS - PROTECTION OF HUMAN SUBJECTS P.T. 42; K.W. 1014002, 0783005 National Institutes of Health Food and Drug Administration The National Institutes of Health (NIH) and the Food and Drug Administration (FDA) are continuing to sponsor a series of workshops on responsibilities of researchers, Institutional Review Boards (IRBs), and institutional officials for the protection of human subjects in biomedical and behavioral research. The workshops are open to everyone with an interest in research. The meetings should be of special interest to those persons currently serving or about to begin serving as a member of an IRB. The current schedule includes: o Dates: January 19-20, 1989 Location: Long Beach, California Title of Workshop: "Western Regional Workshop on Human Subjects Protection" Contact: Dr. Samuel J. Shacks or Mrs. Mary Quach Charles R. Drew University of Medicine and Science 1621 East 120th Street Los Angeles, California 90059 Telephone: (213) 563-5900 o Date: February 2-3, 1989 Location: Tempe, Arizona Title of Workshop: "Ethical Issues Surrounding the Use of Human Subjects in Research" Contact: Ms. Carol Jablonski Human Subjects Coordinator Office of Research Development and Administration Arizona State University Tempe, Arizona 85287 Telephone: (602) 965-2170 Vol. 17, No. 43, December 23, 1988 - Page 2 o Dates: March 9-10, 1989 Location: Birmingham, AL Title of Workshop: "Institutional Review Board Workshop on Bioethical Considerations in Research with Human Subjects" Contact: Ms. Susan Nuckols Division of Continuing Medical Education University of Alabama at Birmingham 127 CHSB Birmingham, Alabama 35294 Telephone: (1-800) 292-6508 in Alabama (1-800) 452-9860 outside Alabama Additional workshops will be announced later. For further information regarding education programs contact: Darlene Marie Ross Education Program Coordinator Office for Protection from Research Risks National Institutes of Health Building 31, Room 4B09 9000 Rockville Pike Bethesda, Maryland 20892 Telephone: (301) 496-8101 COORDINATING CENTER FOR COLLABORATIVE STUDIES ON THE GENETICS OF ALCOHOLISM RFA AVAILABLE: 89-AA-01A P.T. 04; K.W. 0404003, 1002019, 0745020, 0760003 National Institute on Alcohol Abuse and Alcoholism Application Receipt Date: April 3, 1989 PURPOSE NIAAA announces the availability of an RFA to support a Coordinating Center for a collaborative research effort to identify the gene(s) which influence susceptibility to alcoholism. RESEARCH OBJECTIVES This collaborative study will involve genetic studies of alcoholics and their relatives, the acquisition of immortalized lymphocytes for DNA analysis, and investigations of the association of potential genetic markers with the expression of the alcoholic phenotype(s) in the families being studied. MECHANISM OF SUPPORT The study will involve the cooperation of scientists from: (1) a single Coordinating Center, (2) multiple Extramural Research Groups, (3) an NIAAA Intramural Research Group, and (4) the NIAAA Extramural Program. The primary governing body of the study will be the Steering Committee, composed of the principal investigator of the Coordinating Center, the principal investigator of each of the Extramural Research Groups, the principal investigator of the NIAAA Intramural Research Group, the NIAAA Staff Collaborator and any other individuals from participating sites needed to ensure appropriate coverage of subject matter and balance. A Genetics of Alcoholism Collaborative Project Advisory Committee will be formed, composed of experts in the alcohol research field or in the other fields relevant to the project. Applications for the Coordinating Center will be accepted only from domestic institutions. The award for the Coordinating Center will be made in the form of a cooperative agreement. The Coordinating Center will provide overall study coordination and management; development, refinement, testing and/or training in common diagnostic protocols, as required; a DNA and cell repository; a common data repository; data storage and analysis capabilities; and executive secretariat functions. It may also coordinate laboratory functions, phenotypic testing procedures or linkage analysis if this is deemed desirable in the planning phase. The Coordinating Center may involve a single institution or multi-institution collaboration. Investigators submitting a Vol. 17, No. 43, December 23, 1988 - Page 5 proposal to become the Coordinating Center may also submit a separate proposal to function as one of the Extramural Research Groups (RFA 89-AA-01B). NIAAA plans to make multiple awards for the three phases of the project up to five years and has set aside 3.5 million dollars for the initial year's funding. Prospective applicants are asked to submit a letter of intent by March 1, 1989 to: Mark Green, Ph.D. Chief, Extramural Project Review Branch, NIAAA 16-C-20 Parklawn Building 5600 Fishers Lane Rockville, Maryland 20857 Telephone: (301) 443-4375 The following office may be contacted for necessary application material: National Clearinghouse for Alcohol and Drug Information Reference Department Box 2345 Rockville, Maryland 20852 Telephone: (301) 468-2600 This RFA is a one-time request for applications. Applicants who wish also to apply for consideration as an Extramural Research Group should submit a separate application with the title, "Extramural Research Group for Collaborative Studies on the Genetics of Alcoholism", RFA 89-AA-01B. THE RFA LABEL FOUND IN THE PHS 398 KIT MUST BE AFFIXED TO THE BOTTOM OF THE FACE PAGE OF THE ORIGINAL COMPLETED APPLICATION FORM, PHS 398. FAILURE TO USE THIS LABEL COULD RESULT IN DELAYED PROCESSING OF YOUR APPLICATION SUCH THAT IT MAY NOT REACH THE REVIEW COMMITTEE IN TIME FOR REVIEW. THERE WILL BE NO OBLIGATION TO REVIEW SUCH APPLICATIONS. Send or deliver the completed application and four (4) signed, exact photocopies of it to: Division of Research Grants Westwood Building, Room 240 National Institutes of Health Bethesda, Maryland 20892** SEND TWO ADDITIONAL COPIES OF THE APPLICATION TO DR. MARK GREEN AT THE ADDRESS LISTED UNDER LETTER OF INTENT. IT IS IMPORTANT TO SEND THESE TWO COPIES AT THE SAME TIME AS THE ORIGINAL AND FOUR COPIES ARE SENT TO THE DIVISION OF RESEARCH GRANTS IN ORDER TO ENSURE THAT THE APPLICATION WILL BE REVIEWED IN COMPETITION FOR THIS RFA. Applications must be received by April 3, 1989. An application not received by this date will be considered ineligible. INQUIRIES For further information contact: W. Sue Badman Shafer, Ph.D. Acting Director, Division of Basic Research, NIAAA 14-C-10 Parklawn Building 5600 Fishers Lane Rockville, Maryland 20857 Telephone: (301) 443-2530 EXTRAMURAL RESEARCH GROUPS FOR COLLABORATIVE STUDIES ON THE GENETICS OF ALCOHOLISM RFA AVAILABLE: 89-AA-01B P.T. 34; K.W. 0404003, 1002019, 0760002 National Institute on Alcohol Abuse and Alcoholism Application Receipt Date: April 3, 1989 PURPOSE NIAAA announces the availability of an RFA to support two to five Extramural Vol. 17, No. 43, December 23, 1988 - Page 6 Research Groups for a collaborative research effort to identify the gene(s) which influence susceptibility to alcoholism. RESEARCH OBJECTIVES This collaborative study will involve genetic studies of alcoholics and their relatives, the acquisition of immortalized lymphocytes for DNA analysis, and investigation of the association of potential genetic markers with the expression of the alcoholic phenotype(s) within the families being studied. MECHANISM OF SUPPORT This study will involve the cooperation of scientists from: (1) a single Coordinating Center, (2) multiple Extramural Research Groups, (3) an NIAAA Intramural Research Group, and (4) the NIAAA Extramural Program. The primary governing body of the study will be the Steering Committee, composed of the principal investigator of the Coordinating Center, the principal investigator of each of the Extramural Research Groups, the principal investigator of the NIAAA Intramural Research Group, the NIAAA Staff Collaborator and any other individuals from participating sites needed to ensure appropriate coverage of subject matter and balance. A Genetics of Alcoholism Collaborative Project Advisory Committee will be formed, composed of experts in the alcohol research field or in the other fields relevant to the project. Applications for the Extramural Research Groups will be accepted from domestic and foreign institutions. Awards for the Extramural Research Groups will be made in the form of a cooperative agreement. The final plan for the study will be based on the successful proposals. The Extramural Research Groups will be responsible for the major portion of the performance of the study. Each Extramural Research Group will perform many, if not all, of the different research activities needed for the study. However, a single Extramural Research Group need not necessarily possess the entire range of capabilities needed for the collaborative study, but may contribute some unique capabilities judged by peer review to be necessary to participate in the study. Proposals for the Extramural Research Groups may involve a single institution or a multi-institution collaboration. Investigators submitting a proposal to become one of the Extramural Research Groups may also submit a separate proposal to function as the Coordinating Center (RFA 89-AA-01A). The Extramural Research Groups will be selected as described in RFA 89-AA-01B. The role of NIAAA extramural staff and intramural research group is described in the RFA. NIAAA plans to make multiple awards for the three phases of the project up to five years and has set aside 3.5 million dollars for the initial year's funding. Prospective applicants are asked to submit a letter of intent by March 1, 1989, to: Mark Green, Ph.D. Chief, Extramural Project Review Branch, NIAAA 16-C-20 Parklawn Building 5600 Fishers Lane Rockville, Maryland 20857 Telephone: (301) 443-4375 The following office may be contacted for necessary application material: National Clearinghouse for Alcohol and Drug Information Reference Department Box 2345 Rockville, Maryland 20852 Telephone: (301) 468-2600 This RFA is a one-time request for applications. Applicants who wish also to apply for consideration as a Coordinating Center should submit a separate application with the title, "Coordinating Center for Collaborative Studies on the Genetics of Alcoholism", RFA 89-AA-01A. THE RFA LABEL FOUND IN THE PHS 398 KIT MUST BE AFFIXED TO THE BOTTOM OF THE FACE PAGE OF THE ORIGINAL COMPLETED APPLICATION FORM, PHS 398. FAILURE TO USE THIS LABEL COULD RESULT IN DELAYED PROCESSING OF YOUR APPLICATION SUCH THAT IT MAY NOT REACH THE REVIEW COMMITTEE IN TIME FOR REVIEW. THERE WILL BE NO OBLIGATION TO REVIEW SUCH APPLICATIONS. Send or deliver the completed application and four (4) signed, exact photocopies of it to: Vol. 17, No. 43, December 23, 1988 - Page 7 Division of Research Grants Westwood Building, Room 240 National Institutes of Health Bethesda, Maryland 20892** SEND TWO ADDITIONAL COPIES OF THE APPLICATION TO DR. MARK GREEN AT THE ADDRESS LISTED UNDER LETTER OF INTENT. IT IS IMPORTANT TO SEND THESE TWO COPIES AT THE SAME TIME AS THE ORIGINAL AND FOUR COPIES ARE SENT TO THE DIVISION OF RESEARCH GRANTS IN ORDER TO ENSURE THAT THE APPLICATION WILL BE REVIEWED IN COMPETITION FOR THIS RFA. Applications must be received by April 3, 1989. An application not received by this date will be considered ineligible. INQUIRIES For further information contact: W. Sue Badman Shafer, Ph.D. Acting Director, Division of Basic Research, NIAAA 14-C-10 Parklawn Building, 5600 Fishers Lane Rockville, Maryland 20857 (301) 443-2530