Path: utzoo!utgpu!watmath!iuvax!bionet!sysh.surrey.ac.uk!MBY134
From: MBY134@sysh.surrey.ac.uk
Newsgroups: bionet.jobs
Subject: (none)
Message-ID: <8903131333.AA11985@net.bio.net>
Date: 13 Mar 89 13:28:34 GMT
Sender: daemon@NET.BIO.NET
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Post#`Doctoral#`Molecular#`Biologist#`required#`in#`The#`Molecular#MMicrobiology
#`Group,#`Department#`of#`Microbiology,#`University#`of#MSurrey,#`Guildford,#`Su
rrey,#`UK.#J#JThe#`position#`is#`funded#`for#`two#`years#`from#`1#`April#`1989,#
`by#`the#MNational#`Foundation#`for#`Ileitis#`and#`Colitis#`of#`America#`and#`is
#`to#Mdevelop#`the#`polymerase#`chain#`reaction#`for#`detection#`of#Mmycobacteri
al#`DNA#`in#`Crohn's#`disease.#`Crohn's#`disease#`is#`a#Mchronic#`incurable#`int
estinal#`inflammatory#`condition#`that#`affects#Mapproximately#`50#`000#`people#
`in#`the#`UK#`and#`many#`more#`in#`the#`USA.#MThe#`cause#`is#`unknown#`though#`m
ycobacteria,#`particularly#MMycobacterium#`paratuberculosis#`have#`been#`implica
ted.#`We#`have#Mdeveloped#`DNA#`probes#`for#`specific#`detection#`of#`mycobacter
ia#M(McFadden#`et#`al#`1987.#`J.#`Clin.#`Microbiol.#`25:#`796#`&)#`801;#`McFadde
n#Met#`al#`1987.#`Mol.#`Microbiol.#`1:#`283#`&)#`291).#`DNA#`sequence#Mdetermine
d#`from#`these#`probes#`will#`be#`used#`to#`synthesize#`specific#Mprimers#`for#`
enzymic#`amplification#`of#`mycobacterial#`DNA#`in#`samples#Mderived#`from#`Croh
n's#`disease#`sample#`and#`cultures.#`The#`association#Mof#`mycobacteria#`with#`
Crohn's#`disease#`will#`be#`determined.#`Rapid#Mdetection#`of#`mycobacteria#`in#
`patient#`samples#`will#`allow#`specific#Mtargeted#`treatment#`and#`hopefully,#`
cure#`of#`this#`disease.#J#JStarting#`salary#`will#`be#`up#`to#`&a&#\&a14033#`pe
r#`annum.#`Applications#`in#Mthe#`form#`of#`a#`curriculum#`vitae#`(3#`copies),#`
including#`the#`names#Mand#`adresses#`of#`two#`referees,#`should#`be#`sent#`to#`
the#`Personnel#MOffice#`(JLG),#`University#`of#`Surrey,#`Guildford,#`Surrey,#`GU
2#`5XH,#MUK,#`by#`24#`March#`1989#`quoting#`reference#`816.#`Further#`details#`c