Path: utzoo!utgpu!watmath!iuvax!bionet!nihcu.bitnet!CZJ From: CZJ@nihcu.bitnet Newsgroups: bionet.sci-resources Subject: (none) Message-ID: <8903311913.AA22330@net.bio.net> Date: 31 Mar 89 18:56:47 GMT Sender: daemon@NET.BIO.NET Lines: 539 Attached is the Table of Contents and Items of Interest from the NIH Guide to Grants and Contracts 3/31/89. Jim Cassatt ---------- Vol. 18, No. 11, March 31, 1989 NOTICES CANCER EDUCATION PROGRAM ...................................(84/98)......... 1 National Cancer Institute Index: CANCER STEVENS AMENDMENT TO THE DEPARTMENT OF DEFENSE APPROPRIATIONS ACT .......... 1 Public Health Service (101/123) Index: PUBLIC HEALTH SERVICE METHODS OF MOLECULAR MECHANICS AND DYNAMICS OF BIOPOLYMERS WORKSHOP, PITTSBURGH SUPERCOMPUTING CENTER ..................(126/182)....... 1 Division of Research Resources Index: RESEARCH RESOURCES NIH REGIONAL CONFERENCE IN GRANTS ADMINISTRATION ............(185/227)....... 2 National Institutes of Health Index: NATIONAL INSTITUTES OF HEALTH DATED ANNOUNCEMENTS (RFPs AND RFAs) DEVELOPMENT AND TESTING OF NEW MALE AND FEMALE CONDOMS (RFP) ..(244/276)..... 3 National Institute of Child Health and Human Development Index: CHILD HEALTH, HUMAN DEVELOPMENT HOUSING, MAINTENANCE AND ROUTINE TESTING OF AIDS INFECTED RESEARCH ANIMALS (RFP) ......................................(279/313)....... 3 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES COMPUTATIONAL NEURONAL MODELING (RFP) .......................(321/382)....... 4 National Institute of Neurological Disorders and Stroke Index: NEUROLOGICAL DISORDERS, STROKE REDUCING FRAILTY AND INJURIES IN OLDER PERSONS (RFA) ....(385/532, 804/1585). 4 National Institute on Aging National Center for Nursing Research Index: AGING, NURSING RESEARCH MINORITY MENTAL HEALTH RESEARCH CENTERS (RFA) ..............(535/586)........ 6 National Institute of Mental Health Index: MENTAL HEALTH RESEARCH TRAINING AND CAREER DEVELOPMENT AWARDS FOR PHYSICIANS IN NUTRITION (RFA) ...................................(589/649, 1588/1740)... 7 National Institute of Diabetes and Digestive and Kidney Diseases Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES ONGOING PROGRAM ANNOUNCEMENTS MINORITY RESEARCH PROGRAM ADMINISTRATIVE SUPPLEMENTAL AWARDS ..(655/715)..... 8 National Institute on Alcohol Abuse and Alcoholism National Institute on Drug Abuse Index: ALCOHOL ABUSE, ALCOHOLISM, DRUG ABUSE ERRATUM STUDIES OF DIABETES MELLITUS AND RELATED PROBLEMS (PA) ........(724/746)..... 9 National Institute of Diabetes and Digestive and Kidney Diseases Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES SPECIAL EMPHASIS RESEARCH CAREER AWARD (SERCA) IN LABORATORY ANIMAL SCIENCE (PA) ............................................(749/772).... 9 Division of Research Resources Index: RESEARCH RESOURCES NOTICES CANCER EDUCATION PROGRAM (R25) P.T. 34; K.W. 0715035, 0403004, 0795003 National Cancer Institute The next application receipt dates for the Cancer Education Program (R25) will be October 1, 1989, for new applications and November 1, 1989, for renewal applications. The June and July 1989 receipt dates will be skipped; therefore, any applications received on those dates will be deferred to the next cycle. The timetable for all these applications will be as follows: initial review for scientific merit, February 1990; second level review by the National Cancer Advisory Board, May 1990. Please contact the Cancer Training Branch, (Dr. Robert Adams, (301) 496-8580), if you have any questions concerning this announcement. STEVENS AMENDMENT TO THE DEPARTMENT OF DEFENSE APPROPRIATIONS ACT P.T. 34; K.W. 1014002, 1014006 Public Health Service The Office of Management and Budget has advised the heads of all departments and agencies about a government-wide requirement set forth in Section 8136 of the Department of Defense (DOD) Appropriations Act for fiscal year 1989. Specifically, Section 8136 (The "Stevens Amendment") reads as follows: "When issuing statements, press releases, requests for proposals, bid solicitations, and other documents describing projects or programs funded in whole or in part with Federal money, all grantees receiving Federal funds, including but not limited to State and local governments, shall clearly state (1) the percentage of the total cost of the program or project which will be financed with Federal money, and (2) the dollar amount of Federal funds for the project or program." All recipients of Public Health Service grants (and cooperative agreements) involving fiscal year 1989 appropriated funds must comply with the requirements of Section 8136. METHODS OF MOLECULAR MECHANICS AND DYNAMICS OF BIOPOLYMERS WORKSHOP, PITTSBURGH SUPERCOMPUTING CENTER P.T. 42; K.W. 0790010, 0760060, 1004000 Division of Research Resources The Pittsburgh Supercomputing Center (PSC) is conducting a three-day workshop on "Methods of Molecular Mechanics and Dynamics of Biopolymers," May 31, June 1-2, 1989, for biomedical researchers. This workshop is funded by a grant from the Division of Research Resources' Biomedical Research Technology (BRT) Program of the National Institutes of Health (NIH). The workshop will familiarize biomedical researchers with computational methods and provide practice in applying supercomputing resources to problems of concern in molecular mechanics. Previous programming or supercomputing experience is desirable but not necessary. Practical experience on the Pittsburgh Supercomputing Center's Cray Y-MP/832 will be gained in the application to: (1) the problem of conformational mapping and analysis of polypeptide structures; (2) the structural refinement of polypeptides, proteins, and nucleic acids using constraints from measured NMR data; and (3) computation of interaction energies and free energies for protein-drug interactions. The use of state-of-the-art macromolecular computational packages will be illustrated. The workshop will be led by Dr. Charles L. Brooks III, Carnegie Mellon University. This three-day workshop will include an optional half-day session the morning of May 31 led by PSC staff members. Topics to be covered during the optional session include VAX, VMS, and UNICOS, the Cray version of the AT&T System V Unix operating system. Vol. 18, No. 11, March 31, 1989 - Page 1 Travel, meals, and hotel accommodations are covered for U.S. academic participants under the grant. Enrollment is limited to 20 participants. THE DEADLINE FOR SUBMISSION OF APPLICATIONS IS APRIL 20, 1989. To apply for the workshop send a letter accompanied by a curriculum vitae to Cherolyn Brooks at the address below. The letter should outline your research background and current research activities and interests, together with a brief description (one paragraph) of a problem that may be addressed in this workshop. The applicant's level of FORTRAN programming experience and supercomputing experience, if any, should also be included. In addition, graduate students should submit a letter of recommendation written by a faculty member. For further information, call or write to: Cherolyn A. Brooks User Services Pittsburgh Supercomputing Center 4400 Fifth Avenue Pittsburgh, Pennsylvania 15213 Telephone: (412) 268-5206, 1-800-222-9310 (Pennsylvania) 1-800-221-1641 (outside Pennsylvania) NIH REGIONAL CONFERENCE IN GRANTS ADMINISTRATION P.T. 42; K.W. 1014006 National Institutes of Health A two-day conference covering topics related to both program funding and grants administration at the National Institutes of Health is planned for May 25-26, 1989, at Mississippi State University in Starkville. The conference is targeted for an audience of researchers and research administrators at institutions in the southern region which includes Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, and Tennessee. Those interested from Arkansas and Louisiana are also encouraged to attend. Investigators and staff from small and minority colleges, for-profit research organizations, hospitals, universities, and research institutes are invited. This two-day conference has a dual focus of interest to both researchers and grants administrators. Discussions of current issues that affect NIH funding and grants administration are included to give conference participants a comprehensive, up-to-date view of NIH-sponsored research. The first day of the conference is devoted to discussions of current interest to the research programs of the various institutes that comprise the NIH. Preparation of an NIH proposal and the NIH review process are included as agenda topics. Program representatives from three of the NIH institutes and the National Institute on Drug Abuse of the Alcohol, Drug Abuse and Mental Health Administration are featured speakers. Time will be available for conference participants to meet informally with the NIH representatives and discuss topics of special interest. The program for the second day covers topics associated with pre-award and post-award administration of NIH grants. Policy and procedural issues affecting NIH grants administration form the basis for the program. General discussions on current issues and the changes they precipitate are integrated with more specific discussions regarding special career development programs and lab safety. Mr. Geoffrey Grant, Grants Policy Officer in the Office of Extramural Research at NIH, and representatives from the Division of Research Grants and program and grants management staff of several institutes are featured speakers. Conference information will be mailed out in early April, and the deadline for conference registration is May 5th. Dr. Bev. R. Norment at Mississippi State University is in charge of conference arrangements. For more information, contact him or his assistant, Ms. Donna Echols, at (601) 325-3570. Vol. 18, No. 11, March 31, 1989 - Page 2 DATED ANNOUNCEMENTS (RFPs AND RFAs) DEVELOPMENT AND TESTING OF NEW MALE AND FEMALE CONDOMS RFP AVAILABLE: NICHD-BAA-89-16 P.T. 34; K.W. 0750020 National Institute of Child Health and Human Development The Contraceptive Development Branch of the Center for Population Research, National Institute of Child Health and Human Development, has a requirement to develop, design, and test new non-latex or modified latex condoms for male and female use possessing the following characteristics: (a) tensile and air burst strength greater than present latex condoms; (b) uniform wall thickness; (c) non-sensitizing, (d) pin-hole free, or porosity smaller than 40 microns; (e) spermicide compatibility; (f) extended shelf-life; (g) shipping stability. Proposals to develop new potential materials or to test or compare marketed products will not be accepted under this RFP. It is anticipated that three contract awards will be made for a maximum period of five years each depending upon the nature and complexity of the proposed research. This is not a Request for Proposals. RFP-NICHD-BAA-89-16 will be issued on or about April 11, 1989, as a Broad Agency Announcement as defined in FAR 6.102 (d)(2). Proposals will be due approximately 90 days thereafter. Copies of the RFP may be obtained by sending written requests to Mr. Paul J. Duska at the address listed below. Requests may also be made by FAX Telephone (301) 496-0962. Paul J. Duska, Contracting Officer Contracts Management Section, OGC National Institute of Child Health and Human Development Executive Plaza North, Room 610 9000 Rockville Pike Bethesda, Maryland 20892 HOUSING, MAINTENANCE AND ROUTINE TESTING OF AIDS INFECTED RESEARCH ANIMALS RFP AVAILABLE: RFP-NIH-NIAID-OSD-90-12 P.T. 34; K.W. 1002002, 0715008 National Institute of Allergy and Infectious Diseases The Intramural Research Program, Office of the Scientific Director of the National Institute of Allergy and Infectious Diseases, has a requirement for housing and maintenance of up to 12 adult chimpanzees while conducting directed research studies with human immunodeficiency viruses. Offerors must have facilities and trained personnel for working with infectious disease agents in chimpanzees. Any contract awarded will be subject to DHHS regulations regarding the use of animal subjects in research. The Institute plans to make one award from this solicitation. RFP-NIH-NIAID-OSD-90-12 will be issued on or about April 14, 1989, with a closing date for receipt of proposals tentatively set for June 2, 1989. To receive a copy of the RFP, please supply this office with two (2) self-addressed mailing labels. All responsible sources may submit a proposal which will be considered by NIAID. Request for the RFP should be directed to: Ms. Joyce U. Sagami National Institute of Allergy and Infectious Diseases Westwood Building, Room 707 5333 Westbard Avenue Bethesda, Maryland 20892 Telephone: (301) 496-2509 This advertisement does not commit the Government to award a contract. Vol. 18, No. 11, March 31, 1989 - Page 3 COMPUTATIONAL NEURONAL MODELING RFP AVAILABLE: NIH-NINDS-89-06 P.T. 34; K.W. 0705055, 1004000 National Institute of Neurological Disorders and Stroke The National Institute of Neurological Disorders and Stroke (NINDS) has a new requirement for computational neuronal modeling. This contract is the first phase of a long-term effort to develop a sound functional mathematical description of the nature and behavior of learning, storage, and recall in vertebrate biological systems. Such a mathematical description, even in its early stages of development will serve two principal, mutually reinforcing functions. It will facilitate the design of further neurobiological experiments and it will serve as the basis for the development of numerical models that clearly demonstrate the pattern recognition and classification capabilities of animals and man. The work required of the Contractor shall consist of the following interrelated tasks: 1) develop a detailed, lumped-parameter model (that can be numerically emulated using a computer as a tool) of invertebrate and vertebrate neural systems exhibiting associate learning, storage, and recall that bears a one-to-one relationship to biological reality; 2) develop a mathematical model of the underlying input/output relations of the models; 3) demonstrate the validity of the mathematical model by numerical emulation of that model using the mathematical model rather than a one-to-one description of biological reality; and 4) utilizing the emulations, demonstrate as clearly as possible the ability of these algorithms to learn, store, recall, and associate inputs, using realistic test cases. Offerors must have: 1) experience in computer modeling and mathematical analysis of neural networks (artificial and natural), non-linear systems, and/or non-linear optimization theory and applications; 2) personnel qualified to perform interdisciplinary research spanning computer science/engineering/physics/systems science on the one hand and biomedical sciences on the other; and 3) computer hardware/software resources adequate to carry out the proposed work, including facilities to execute efficiently large neural network computer programs with consequent large data/program memory requirements. It is anticipated that one contract award will be made under this RFP, for a three-year period. This is not a Request for Proposals (RFP). RFP No. NIH-NINDS-89-06 will be issued on or about March 27, l989, with tentative date for receipt of proposals set at May l9, l989. To receive a copy of the RFP, please submit a written request to the following address and supply this office with two self-addressed mailing labels. All responsible sources may submit a proposal which will be considered by the Government. Contracting Officer Contracts Management Branch, DEA National Institute of Neurological Disorders and Stroke, NIH Federal Building, Room 901 7550 Wisconsin Avenue Bethesda, Maryland 20892 Attn: RFP-NIH-NINDS-89-06 REDUCING FRAILTY AND INJURIES IN OLDER PERSONS RFA AVAILABLE: 89-AG/NR-04 P.T. 34; K.W. 0715027, 0745027, 0745030, 0710010, 0415003 National Institute on Aging National Center for Nursing Research Application Receipt Date: July 19, 1989 Vol. 18, No. 11, March 31, 1989 - Page 4 PURPOSE This announcement invites cooperative agreement applications for: i) Sites to carry out biomedical, behavioral or environmental intervention studies designed to reduce the loss of functional capacities and to prevent fall-related injuries in older persons; and ii) a Coordinating Center for these intervention studies. Two related investigative approaches are sought: o Studies aimed at increasing physical functional capacities and reducing injuries by improving mobility, strength, and balance. o Studies aimed at optimizing health behaviors and/or environmental conditions with the intent of reducing fear of falling, the actual occurrence of falls, consequent injuries, or other negative sequelae. BACKGROUND A major goal of research related to aging is to increase the period of time that older individuals are able to function independently and in relatively good health. The September 1988 "Workshop on Reducing Frailty and Fall-Related Injuries in Older Persons" sponsored by the National Institute on Aging (NIA), National Center for Nursing Research (NCNR) and the Centers for Disease Control, presented current knowledge on these subjects. Recommendations were for the need to: i) conduct initial studies to test the efficacy of different intervention approaches; ii) encourage interventions in populations with either low, intermediate or high functional impairment with the intervention well matched to the appropriate target population; iii) select outcome measures very carefully and with full awareness of required sample size; iv) emphasize functional capacities and health behaviors as critical outcome measures; and vi) evaluate factors which may affect compliance with the interventions in these populations. RESEARCH GOALS AND SCOPE Applications are invited which propose studies to test intervention strategies for the prevention, reduction or compensation of physical frailties or environmental hazards which place older persons at risk for injuries. It is anticipated that there will be 6-8 Sites and one Coordinating Center which must be independent of the Sites. A multidisciplinary approach is encouraged as appropriate to the proposed intervention. Examples of interventions to increase physical capacities include, but are not limited to: o Rehabilitation programs to restore functional deficits related to cardiovascular, musculoskeletal and other dysfunctions among older persons. o Exercise and/or nutritional interventions designed to improve muscular strength and/or bone strength. o Exercise regimens to improve postural stability and/or range of motion. o Interventions to increase mobility and strength in older individuals with arthritis. Examples of interventions to enhance health behaviors and/or environments include, but are not limited to: o Interventions to identify and eliminate risk-related environmental hazards in the home or institutional setting. o Behavioral strategies to increase older individuals' recognition of injury risk, avoidance of imprudent behaviors associated with injury risk, and adoption of appropriate behavioral responses to reduced functional capacities. o Psychosocial interventions to reduce incapacitating fear of falling and increase psychosocial functioning. o Development and testing of special falls reduction programs in institutional settings. Vol. 18, No. 11, March 31, 1989 - Page 5 MECHANISM OF SUPPORT The administrative and funding mechanism to be used to support these awards will be cooperative agreements between each awardee and NIH. This study will involve the cooperation of scientists from: 1) multiple research Sites, 2) a Coordinating Center, and 3) two NIH units (NIA and NCNR). A Steering Committee will serve as the study's primary governing body. The proposed start date is April 1, 1990. Support may be requested for up to 3 years for Sites but must be requested for the full 3 years by the Coordinating Center. REVIEW PROCEDURES AND CRITERIA Applications will be received by the NIH Division of Research Grants and will be dually assigned to NIA and NCNR. Applications judged by NIA or NCNR to be nonresponsive will not be accepted. Responsive applications may be subjected to triage by a peer review group to determine their scientific merit relative to the other applications received in response to this RFA. Applications will be reviewed in accord with the usual NIH peer review procedures. METHOD OF APPLYING The full version of this RFA should be requested and the instructions it contains for completing applications should be followed. Researchers considering an application in response to this RFA are strongly encouraged to discuss their project with NIA or NCNR program administrators in advance of formal submission. This can be done either through a telephone conversation or a brief letter giving the title of the proposed project, the principal investigator and, when known, other key participants. This letter should be sent to the appropriate staff contact listed below by June 14, 1989. INQUIRIES Presubmission inquiries and correspondence can be directed to these NIA and NCNR contact offices listed below. Geriatrics Branch National Institute on Aging Building 3l, Room 5C27 Bethesda, Maryland 20892 Telephone: (301) 496-1033 Behavioral and Social Research Program National Institute on Aging Building 3l, Room 5C32 Bethesda, Maryland 20892 Telephone: (301) 496-3136 Health Promotion and Disease Prevention Branch National Center for Nursing Research Building 31, Room 5B13 Bethesda, Maryland 20892 Telephone: (301) 496-0523