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Path: utzoo!utgpu!jarvis.csri.toronto.edu!mailrus!ncar!boulder!eesnyder
From: eesnyder@boulder.Colorado.EDU (Eric E. Snyder)
Newsgroups: alt.drugs,sci.chem,sci.bio
Subject: QSARs and phenylalkylamine psychotomimetics
Message-ID: <16512@boulder.Colorado.EDU>
Date: 3 Feb 90 00:45:33 GMT
Sender: news@boulder.Colorado.EDU
Reply-To: eesnyder@beagle.Colorado.EDU (Eric E. Snyder)
Organization: University of Colorado, Boulder
Lines: 19

I just came across a really interesting article on structure-activity 
relationships in phenylalkylamine psaychotomimetics.  Check out:

Clare, BW. J. Med. Chem. 1990, 33, 687-702.

It is easily the most comprehensive examination of the subject to date.
Although it overlooks a number of important "biological" considerations
and is forced to rely heavily on dubious human activity data, it certainly
makes a heroic effort.  I would appreciate the comments of anyone versed
in computational chemistry as to the soundness of the methodology.....

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Eric E. Snyder                            
Department of Biochemistry              Proctoscopy recapitulates   
University of Colorado, Boulder         hagiography.            
Boulder, Colorado 80309                  
LeuIleAlaLysHisTrpAlaAlaAsnGlnGlyTrpAspLeuAsnLysAspGlyGlnIleGlnPheValLeuLeu
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